Matrix Metalloproteinase 23B (MMP23B)

MMP22; MMP23-B; MIFR; MIFR-1; Matrix Metalloproteinase 22; Femalysin; Matrix Metalloproteinase In The Female Reproductive Tract

SPN	W532
HGNC	7171
MGI	1347361
PubMed	21064033
RGD	620201
UniProt	O75900
Wiki	MMP23B

• The gene for MMP-22 has been identified together with the gene for MMP-21 in the Cdc2L1-2 locus at the end of the short arm of human chromosome 1, 1p36.3, which is deleted frequently in a number of tumors (Gururajan et al, 1998). The gene has been renamed MMP-23B and its sequence is almost identical with that of MMP-21. The catalytic domain of MMP-22 is related most closely to MMP-11 (stromelysin-3). The protein does not contain a highly conserved cysteine residue in the proenzyme domain, shown to be involved in the autocatalytic activation of many metalloproteinases. Multiple MMP-22 mRNAs, some of which are derived by alternative splicing, are expressed in a tissue-specific manner. For other entries pertaining to metalloproteinases see also the Metalloproteinase Dictionary section of this encyclopedia.

Reference

"Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3."
Genomics 52:101-106(1998) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members."
J. Biol. Chem. 274:4570-4576(1999) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of a rat ortholog of MMP-23 (matrix metalloproteinase-23), a unique type of membrane-anchored matrix metalloproteinase and conditioned switching of its expression during the ovarian follicular development."
Mol. Endocrinol. 15:747-764(2001) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]