Monocyte Chemotactic Protein 4 (MCP4)
CCL13; SCYA13; NCC1; SCYL1; CKb10; Chemokine C-C-Motif Ligand 13; Small Inducible Cytokine Subfamily A(Cys-Cys)Member 13; CK-beta-10; Monocyte chemoattractant 4
Chemokine (C-C motif) ligand 13 (CCL13) is a small cytokine belonging to the CC chemokine family.The chemokines are secreted proteins involved in immunoregulatory and inflammatory processes. Naruse et al. (1996) identified on chromosome 17q11.2 a cluster of chemokines from the CC family (characterized by a cys-cys sequence motif) and distinguished from a second chemokine family that features a cys-xxx-cys (CXC) motif . They mapped 1 gene of the CC family (called NCC1 by them) to the cluster using a panel of somatic cell hybrids with known deletions. NCC1 was originally characterized as an expressed sequence tag (EST). The deduced order of genes from a YAC contig assembled for the region is cen--NF1--MCP3, MCP1, NCC1, I-309--Y1741 breakpoint--RANTES--LD78-gamma, AT744.2 , LD78-beta --NCC3, NCC2, AT744.1 ), LD78-alpha--NCC4--RARA --tel.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW528Hu01 | Recombinant Monocyte Chemotactic Protein 4 (MCP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW528Hu01 | Monoclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4) | WB; IHC; ICC; IP. |
| PAW528Hu01 | Polyclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW528Hu01 | CLIA Kit for Monocyte Chemotactic Protein 4 (MCP4) | CLIA assay for Antigen Detection |
| ELW528Hu01 | ELISA Kit for Monocyte Chemotactic Protein 4 (MCP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW528Mu01 | Recombinant Monocyte Chemotactic Protein 4 (MCP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW528Mu01 | Monoclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4) | WB; IHC; ICC; IP. |
| PAW528Mu01 | Polyclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW528Mu01 | CLIA Kit for Monocyte Chemotactic Protein 4 (MCP4) | CLIA assay for Antigen Detection |
| ELW528Mu01 | ELISA Kit for Monocyte Chemotactic Protein 4 (MCP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW528Ra01 | Recombinant Monocyte Chemotactic Protein 4 (MCP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW528Ra01 | Monoclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4) | WB; IHC; ICC; IP. |
| PAW528Ra01 | Polyclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW528Ra01 | CLIA Kit for Monocyte Chemotactic Protein 4 (MCP4) | CLIA assay for Antigen Detection |
| ELW528Ra01 | ELISA Kit for Monocyte Chemotactic Protein 4 (MCP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW528Ca01 | Recombinant Monocyte Chemotactic Protein 4 (MCP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW528Ca01 | Monoclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4) | WB; IHC; ICC; IP. |
| PAW528Ca01 | Polyclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW528Ca01 | CLIA Kit for Monocyte Chemotactic Protein 4 (MCP4) | CLIA assay for Antigen Detection |
| ELW528Ca01 | ELISA Kit for Monocyte Chemotactic Protein 4 (MCP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW528Po01 | Recombinant Monocyte Chemotactic Protein 4 (MCP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW528Po01 | Monoclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4) | WB; IHC; ICC; IP. |
| PAW528Po01 | Polyclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW528Po01 | CLIA Kit for Monocyte Chemotactic Protein 4 (MCP4) | CLIA assay for Antigen Detection |
| ELW528Po01 | ELISA Kit for Monocyte Chemotactic Protein 4 (MCP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW528Bo01 | Recombinant Monocyte Chemotactic Protein 4 (MCP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW528Bo01 | Monoclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4) | WB; IHC; ICC; IP. |
| PAW528Bo01 | Polyclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW528Bo01 | CLIA Kit for Monocyte Chemotactic Protein 4 (MCP4) | CLIA assay for Antigen Detection |
| ELW528Bo01 | ELISA Kit for Monocyte Chemotactic Protein 4 (MCP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW528Rb01 | Recombinant Monocyte Chemotactic Protein 4 (MCP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW528Rb01 | Monoclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4) | WB; IHC; ICC; IP. |
| PAW528Rb01 | Polyclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW528Rb01 | CLIA Kit for Monocyte Chemotactic Protein 4 (MCP4) | CLIA assay for Antigen Detection |
| ELW528Rb01 | ELISA Kit for Monocyte Chemotactic Protein 4 (MCP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW528Mo01 | Recombinant Monocyte Chemotactic Protein 4 (MCP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW528Mo01 | Monoclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4) | WB; IHC; ICC; IP. |
| PAW528Mo01 | Polyclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW528Mo01 | CLIA Kit for Monocyte Chemotactic Protein 4 (MCP4) | CLIA assay for Antigen Detection |
| ELW528Mo01 | ELISA Kit for Monocyte Chemotactic Protein 4 (MCP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning and characterization of MCP-4, a novel CC chemokine related to MCP-1 and eotaxin."
Eur. Cytokine Netw. 7:513-513(1996)
"Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3."
J. Immunol. 157:5613-5626(1996) [PubMed] [Europe PMC] [Abstract]
"Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin."
J. Exp. Med. 183:2379-2384(1996) [PubMed] [Europe PMC] [Abstract]
"Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B."
J. Biol. Chem. 272:16404-16413(1997) [PubMed] [Europe PMC] [Abstract]
"Monocyte chemotactic protein-4: tissue-specific expression and signaling through CC chemokine receptor-2."
J. Leukoc. Biol. 61:353-360(1997) [PubMed] [Europe PMC] [Abstract]
"Genomic organization, sequence analysis and transcriptional regulation of the human MCP-4 chemokine gene (SCYA13) in dermal fibroblasts: a comparison to other eosinophilic beta-chemokines."
Biochem. Biophys. Res. Commun. 255:470-476(1999) [PubMed] [Europe PMC] [Abstract]
"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Structure of human monocyte chemoattractant protein 4 (MCP-4/CCL13)."
Acta Crystallogr. D 64:273-278(2008) [PubMed] [Europe PMC] [Abstract]