Interferon Beta (IFNb)
IFNB1; IFN-B; IFB; IFF; IFNB; Interferon Beta 1 Fibroblast
IFN beta elicits a markedly higher antiproliferation response in some cell types such as, embryonal carcinoma, melanoma and melanocytes than do IFN alphas. Higher potency of IFN beta in treatment of multiple sclerosis and certain cancers has been observed. Type I IFNs signal through binding to a common cell surface receptor. Two chains of the receptor, IFNAR1 and IFNAR2, have been identified. Both chains are necessary for function and in the absence of either there is neither high affinity binding nor biological activity. The intracellular portions of the receptor subunits are bound by tyrosine kinases, Jak1 and Tyk2, members of the Janus kinase family. Upon ligand binding these kinases are activated and phosphorylate members of the STAT family of transcription factors, as well as IFNAR1 and 2.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW523Hu01 | Recombinant Interferon Beta (IFNb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW523Hu01 | Monoclonal Antibody to Interferon Beta (IFNb) | WB; IHC; ICC; IP. |
| PAW523Hu01 | Polyclonal Antibody to Interferon Beta (IFNb) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW523Hu01 | CLIA Kit for Interferon Beta (IFNb) | CLIA assay for Antigen Detection |
| ELW523Hu01 | ELISA Kit for Interferon Beta (IFNb) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW523Mu01 | Recombinant Interferon Beta (IFNb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW523Mu01 | Monoclonal Antibody to Interferon Beta (IFNb) | WB; IHC; ICC; IP. |
| PAW523Mu01 | Polyclonal Antibody to Interferon Beta (IFNb) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW523Mu01 | CLIA Kit for Interferon Beta (IFNb) | CLIA assay for Antigen Detection |
| ELW523Mu01 | ELISA Kit for Interferon Beta (IFNb) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW523Ra01 | Recombinant Interferon Beta (IFNb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW523Ra01 | Monoclonal Antibody to Interferon Beta (IFNb) | WB; IHC; ICC; IP. |
| PAW523Ra01 | Polyclonal Antibody to Interferon Beta (IFNb) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW523Ra01 | CLIA Kit for Interferon Beta (IFNb) | CLIA assay for Antigen Detection |
| ELW523Ra01 | ELISA Kit for Interferon Beta (IFNb) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW523Ca01 | Recombinant Interferon Beta (IFNb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW523Ca01 | Monoclonal Antibody to Interferon Beta (IFNb) | WB; IHC; ICC; IP. |
| PAW523Ca01 | Polyclonal Antibody to Interferon Beta (IFNb) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW523Ca01 | CLIA Kit for Interferon Beta (IFNb) | CLIA assay for Antigen Detection |
| ELW523Ca01 | ELISA Kit for Interferon Beta (IFNb) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW523Po01 | Recombinant Interferon Beta (IFNb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW523Po01 | Monoclonal Antibody to Interferon Beta (IFNb) | WB; IHC; ICC; IP. |
| PAW523Po01 | Polyclonal Antibody to Interferon Beta (IFNb) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW523Po01 | CLIA Kit for Interferon Beta (IFNb) | CLIA assay for Antigen Detection |
| ELW523Po01 | ELISA Kit for Interferon Beta (IFNb) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW523Bo01 | Recombinant Interferon Beta (IFNb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW523Bo01 | Monoclonal Antibody to Interferon Beta (IFNb) | WB; IHC; ICC; IP. |
| PAW523Bo01 | Polyclonal Antibody to Interferon Beta (IFNb) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW523Bo01 | CLIA Kit for Interferon Beta (IFNb) | CLIA assay for Antigen Detection |
| ELW523Bo01 | ELISA Kit for Interferon Beta (IFNb) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW523Rb01 | Recombinant Interferon Beta (IFNb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW523Rb01 | Monoclonal Antibody to Interferon Beta (IFNb) | WB; IHC; ICC; IP. |
| PAW523Rb01 | Polyclonal Antibody to Interferon Beta (IFNb) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW523Rb01 | CLIA Kit for Interferon Beta (IFNb) | CLIA assay for Antigen Detection |
| ELW523Rb01 | ELISA Kit for Interferon Beta (IFNb) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW523Mo01 | Recombinant Interferon Beta (IFNb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW523Mo01 | Monoclonal Antibody to Interferon Beta (IFNb) | WB; IHC; ICC; IP. |
| PAW523Mo01 | Polyclonal Antibody to Interferon Beta (IFNb) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW523Mo01 | CLIA Kit for Interferon Beta (IFNb) | CLIA assay for Antigen Detection |
| ELW523Mo01 | ELISA Kit for Interferon Beta (IFNb) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human fibroblast interferon gene lacks introns."
Nucleic Acids Res. 9:1045-1052(1981) [PubMed] [Europe PMC] [Abstract]
"Structure of a chromosomal gene for human interferon beta."
Proc. Natl. Acad. Sci. U.S.A. 78:5305-5309(1981) [PubMed] [Europe PMC] [Abstract]
"The nucleotide sequence of human fibroblast interferon cDNA."
Gene 10:11-15(1980) [PubMed] [Europe PMC] [Abstract]
"Isolation and structure of a human fibroblast interferon gene."
Nature 285:542-547(1980) [PubMed] [Europe PMC] [Abstract]
"The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase."
Nucleic Acids Res. 8:2885-2894(1980) [PubMed] [Europe PMC] [Abstract]
"Synthesis of human fibroblast interferon by E. coli."
Nucleic Acids Res. 8:4057-4074(1980) [PubMed] [Europe PMC] [Abstract]
"On the relationship between human interferon alpha 1 and beta 1 genes."
J. Interferon Res. 5:521-526(1985) [PubMed] [Europe PMC] [Abstract]
"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers."
Nucleic Acids Res. 8:1913-1931(1980) [PubMed] [Europe PMC] [Abstract]
"Assignment of the disulphide bonds of leukocyte interferon."
Nature 289:606-607(1981) [PubMed] [Europe PMC] [Abstract]
"A single amino acid change in IFN-beta1 abolishes its antiviral activity."
Nature 294:563-565(1981) [PubMed] [Europe PMC] [Abstract]
"The crystal structure of human interferon beta at 2.2-A resolution."
Proc. Natl. Acad. Sci. U.S.A. 94:11813-11818(1997) [PubMed] [Europe PMC] [Abstract]
"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]