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Interleukin 2 Receptor Beta (IL2Rb)

CD122; IL2R-b; IL2-RB; P70-75; High affinity IL-2 receptor subunit beta; Interleukin-2 receptor subunit beta; IL-2 receptor subunit beta

Interleukin-2 receptor subunit beta is a protein encoded by the IL2RB gene. The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW517Hu01 Recombinant Interleukin 2 Receptor Beta (IL2Rb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW517Hu01 Monoclonal Antibody to Interleukin 2 Receptor Beta (IL2Rb) WB; IHC; ICC; IP.
PAW517Hu01 Polyclonal Antibody to Interleukin 2 Receptor Beta (IL2Rb) WB; IHC; ICC; IF.
Assay Kits CLW517Hu01 CLIA Kit for Interleukin 2 Receptor Beta (IL2Rb) CLIA assay for Antigen Detection
ELW517Hu01 ELISA Kit for Interleukin 2 Receptor Beta (IL2Rb) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW517Mu01 Recombinant Interleukin 2 Receptor Beta (IL2Rb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW517Mu01 Monoclonal Antibody to Interleukin 2 Receptor Beta (IL2Rb) WB; IHC; ICC; IP.
PAW517Mu01 Polyclonal Antibody to Interleukin 2 Receptor Beta (IL2Rb) WB; IHC; ICC; IF.
Assay Kits CLW517Mu01 CLIA Kit for Interleukin 2 Receptor Beta (IL2Rb) CLIA assay for Antigen Detection
ELW517Mu01 ELISA Kit for Interleukin 2 Receptor Beta (IL2Rb) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW517Ra01 Recombinant Interleukin 2 Receptor Beta (IL2Rb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW517Ra01 Monoclonal Antibody to Interleukin 2 Receptor Beta (IL2Rb) WB; IHC; ICC; IP.
PAW517Ra01 Polyclonal Antibody to Interleukin 2 Receptor Beta (IL2Rb) WB; IHC; ICC; IF.
Assay Kits CLW517Ra01 CLIA Kit for Interleukin 2 Receptor Beta (IL2Rb) CLIA assay for Antigen Detection
ELW517Ra01 ELISA Kit for Interleukin 2 Receptor Beta (IL2Rb) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW517Ca01 Recombinant Interleukin 2 Receptor Beta (IL2Rb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW517Ca01 Monoclonal Antibody to Interleukin 2 Receptor Beta (IL2Rb) WB; IHC; ICC; IP.
PAW517Ca01 Polyclonal Antibody to Interleukin 2 Receptor Beta (IL2Rb) WB; IHC; ICC; IF.
Assay Kits CLW517Ca01 CLIA Kit for Interleukin 2 Receptor Beta (IL2Rb) CLIA assay for Antigen Detection
ELW517Ca01 ELISA Kit for Interleukin 2 Receptor Beta (IL2Rb) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW517Po01 Recombinant Interleukin 2 Receptor Beta (IL2Rb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW517Po01 Monoclonal Antibody to Interleukin 2 Receptor Beta (IL2Rb) WB; IHC; ICC; IP.
PAW517Po01 Polyclonal Antibody to Interleukin 2 Receptor Beta (IL2Rb) WB; IHC; ICC; IF.
Assay Kits CLW517Po01 CLIA Kit for Interleukin 2 Receptor Beta (IL2Rb) CLIA assay for Antigen Detection
ELW517Po01 ELISA Kit for Interleukin 2 Receptor Beta (IL2Rb) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW517Bo01 Recombinant Interleukin 2 Receptor Beta (IL2Rb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW517Bo01 Monoclonal Antibody to Interleukin 2 Receptor Beta (IL2Rb) WB; IHC; ICC; IP.
PAW517Bo01 Polyclonal Antibody to Interleukin 2 Receptor Beta (IL2Rb) WB; IHC; ICC; IF.
Assay Kits CLW517Bo01 CLIA Kit for Interleukin 2 Receptor Beta (IL2Rb) CLIA assay for Antigen Detection
ELW517Bo01 ELISA Kit for Interleukin 2 Receptor Beta (IL2Rb) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW517Rb01 Recombinant Interleukin 2 Receptor Beta (IL2Rb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW517Rb01 Monoclonal Antibody to Interleukin 2 Receptor Beta (IL2Rb) WB; IHC; ICC; IP.
PAW517Rb01 Polyclonal Antibody to Interleukin 2 Receptor Beta (IL2Rb) WB; IHC; ICC; IF.
Assay Kits CLW517Rb01 CLIA Kit for Interleukin 2 Receptor Beta (IL2Rb) CLIA assay for Antigen Detection
ELW517Rb01 ELISA Kit for Interleukin 2 Receptor Beta (IL2Rb) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW517Mo01 Recombinant Interleukin 2 Receptor Beta (IL2Rb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW517Mo01 Monoclonal Antibody to Interleukin 2 Receptor Beta (IL2Rb) WB; IHC; ICC; IP.
PAW517Mo01 Polyclonal Antibody to Interleukin 2 Receptor Beta (IL2Rb) WB; IHC; ICC; IF.
Assay Kits CLW517Mo01 CLIA Kit for Interleukin 2 Receptor Beta (IL2Rb) CLIA assay for Antigen Detection
ELW517Mo01 ELISA Kit for Interleukin 2 Receptor Beta (IL2Rb) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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"IL-2 receptor signaling through the Shb adapter protein in T and NK cells."
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Structure 2:839-851(1994) [PubMed] [Europe PMC] [Abstract]

"Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors."
Science 310:1159-1163(2005) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor."
Proc. Natl. Acad. Sci. U.S.A. 103:2788-2793(2006) [PubMed] [Europe PMC] [Abstract]