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Apolipoprotein C1 (APOC1)

Apo-C1; Truncated apolipoprotein C-I

Apolipoprotein C1 is a lipoprotein with a length of 57 amino acids normally found in plasma and responsible for the activation of esterified lechitin cholesterol with an important role in the exchange of esterified cholesterol between lipoproteins and in removal of cholesterol from tissues.

Its main function is inhibition of CETP, probably by altering the electric charge of HDL molecules. during fasting (like other apolipoprotein C) is found primarily within HDL, meanwhile after a meal it is found within the surface of other lipoproteins. in contrast when proteins rich in triglycerides like chylomicrons and VLDL are broken down this apoprotein is transferred again to the HDL.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW504Hu01 Recombinant Apolipoprotein C1 (APOC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW504Hu01 Monoclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IP.
PAW504Hu01 Polyclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IF.
Assay Kits CLW504Hu01 CLIA Kit for Apolipoprotein C1 (APOC1) CLIA assay for Antigen Detection
ELW504Hu01 ELISA Kit for Apolipoprotein C1 (APOC1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW504Mu01 Recombinant Apolipoprotein C1 (APOC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW504Mu01 Monoclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IP.
PAW504Mu01 Polyclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IF.
Assay Kits CLW504Mu01 CLIA Kit for Apolipoprotein C1 (APOC1) CLIA assay for Antigen Detection
ELW504Mu01 ELISA Kit for Apolipoprotein C1 (APOC1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW504Ra01 Recombinant Apolipoprotein C1 (APOC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW504Ra01 Monoclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IP.
PAW504Ra01 Polyclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IF.
Assay Kits CLW504Ra01 CLIA Kit for Apolipoprotein C1 (APOC1) CLIA assay for Antigen Detection
ELW504Ra01 ELISA Kit for Apolipoprotein C1 (APOC1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW504Ca01 Recombinant Apolipoprotein C1 (APOC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW504Ca01 Monoclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IP.
PAW504Ca01 Polyclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IF.
Assay Kits CLW504Ca01 CLIA Kit for Apolipoprotein C1 (APOC1) CLIA assay for Antigen Detection
ELW504Ca01 ELISA Kit for Apolipoprotein C1 (APOC1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW504Po01 Recombinant Apolipoprotein C1 (APOC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW504Po01 Monoclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IP.
PAW504Po01 Polyclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IF.
Assay Kits CLW504Po01 CLIA Kit for Apolipoprotein C1 (APOC1) CLIA assay for Antigen Detection
ELW504Po01 ELISA Kit for Apolipoprotein C1 (APOC1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW504Bo01 Recombinant Apolipoprotein C1 (APOC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW504Bo01 Monoclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IP.
PAW504Bo01 Polyclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IF.
Assay Kits CLW504Bo01 CLIA Kit for Apolipoprotein C1 (APOC1) CLIA assay for Antigen Detection
ELW504Bo01 ELISA Kit for Apolipoprotein C1 (APOC1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW504Rb01 Recombinant Apolipoprotein C1 (APOC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW504Rb01 Monoclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IP.
PAW504Rb01 Polyclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IF.
Assay Kits CLW504Rb01 CLIA Kit for Apolipoprotein C1 (APOC1) CLIA assay for Antigen Detection
ELW504Rb01 ELISA Kit for Apolipoprotein C1 (APOC1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW504Mo01 Recombinant Apolipoprotein C1 (APOC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW504Mo01 Monoclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IP.
PAW504Mo01 Polyclonal Antibody to Apolipoprotein C1 (APOC1) WB; IHC; ICC; IF.
Assay Kits CLW504Mo01 CLIA Kit for Apolipoprotein C1 (APOC1) CLIA assay for Antigen Detection
ELW504Mo01 ELISA Kit for Apolipoprotein C1 (APOC1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Characterisation of mRNAs encoding the precursor for human apolipoprotein CI."
Nucleic Acids Res. 12:3909-3915(1984) [PubMed] [Europe PMC] [Abstract]

"Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene."
J. Biol. Chem. 263:7277-7286(1988) [PubMed] [Europe PMC] [Abstract]

"Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1."
DNA Seq. 9:89-100(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterisation of a cDNA clone for human apolipoprotein CI and assignment of the gene to chromosome 19."
Hum. Genet. 69:345-349(1985) [PubMed] [Europe PMC] [Abstract]

"The complete amino acid sequence of C-I (apoLp-Ser), an apolipoprotein from human very low density lipoproteins."
J. Biol. Chem. 250:182-190(1975) [PubMed] [Europe PMC] [Abstract]

"The primary structure of apolipoprotein-serine."
J. Biol. Chem. 249:5308-5313(1974) [PubMed] [Europe PMC] [Abstract]

"Exact localization of the familial dysbetalipoproteinemia associated HpaI restriction site in the promoter region of the APOC1 gene."
Biochem. Biophys. Res. Commun. 152:1282-1288(1988) [PubMed] [Europe PMC] [Abstract]

"Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification."
J. Lipid Res. 48:1353-1361(2007) [PubMed] [Europe PMC] [Abstract]

"Higher primates, but not New World monkeys, have a duplicate set of enhancers flanking their apoC-I genes."
Comp. Biochem. Physiol. 11:45-48(2014) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Conformation of two peptides corresponding to human apolipoprotein C-I residues 7-24 and 35-53 in the presence of sodium dodecyl sulfate by CD and NMR spectroscopy."
Biochemistry 34:7401-7408(1995) [PubMed] [Europe PMC] [Abstract]

"Conformational studies of the N-terminal lipid-associating domain of human apolipoprotein C-I by CD and 1H NMR spectroscopy."
Protein Sci. 6:1858-1868(1997) [PubMed] [Europe PMC] [Abstract]

"Conformation of human apolipoprotein C-I in a lipid-mimetic environment determined by CD and NMR spectroscopy."
Biochemistry 38:14475-14484(1999) [PubMed] [Europe PMC] [Abstract]

"Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]

"A functional polymorphism of apolipoprotein C1 detected by mass spectrometry."
FEBS J. 273:4707-4715(2006) [PubMed] [Europe PMC] [Abstract]