Inhibin Binding Protein (INHBP)
IGSF1; IGCD1; IGDC1; INHBP; PGSF2; p120; Immunoglobulin Superfamily Member 1; Immunoglobulin-like domain-containing protein 1; Pituitary gland-specific factor 2
IGSF1 contained 12 Ig-like domains of the C2 (constant region type 2) type. In addition, IGSF1 has a signal sequence and a potential transmembrane domain. IGSF1 was expressed as a 4.7-kb mRNA in many of the tissues tested, with the highest expression in pancreas, testis, and fetal liver. Additional 2.8- and 5.5-kb transcripts were observed in heart and testis, respectively. The cDNAs encoded a predicted 1,327-amino acid protein that was designated 'immunoglobulin superfamily member-1' (IGSF1) because it contained 12 Ig-like domains of the C2 (constant region type 2) type. In addition, IGSF1 has a signal sequence and a potential transmembrane domain. Northern blot analysis revealed that IGSF1 was expressed as a 4.7-kb mRNA in many of the tissues tested, with the highest expression in pancreas, testis, and fetal liver.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW487Hu01 | Recombinant Inhibin Binding Protein (INHBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW487Hu01 | Monoclonal Antibody to Inhibin Binding Protein (INHBP) | WB; IHC; ICC; IP. |
| PAW487Hu01 | Polyclonal Antibody to Inhibin Binding Protein (INHBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW487Hu01 | CLIA Kit for Inhibin Binding Protein (INHBP) | CLIA assay for Antigen Detection |
| ELW487Hu01 | ELISA Kit for Inhibin Binding Protein (INHBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW487Mu01 | Recombinant Inhibin Binding Protein (INHBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW487Mu01 | Monoclonal Antibody to Inhibin Binding Protein (INHBP) | WB; IHC; ICC; IP. |
| PAW487Mu01 | Polyclonal Antibody to Inhibin Binding Protein (INHBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW487Mu01 | CLIA Kit for Inhibin Binding Protein (INHBP) | CLIA assay for Antigen Detection |
| ELW487Mu01 | ELISA Kit for Inhibin Binding Protein (INHBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW487Ra01 | Recombinant Inhibin Binding Protein (INHBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW487Ra01 | Monoclonal Antibody to Inhibin Binding Protein (INHBP) | WB; IHC; ICC; IP. |
| PAW487Ra01 | Polyclonal Antibody to Inhibin Binding Protein (INHBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW487Ra01 | CLIA Kit for Inhibin Binding Protein (INHBP) | CLIA assay for Antigen Detection |
| ELW487Ra01 | ELISA Kit for Inhibin Binding Protein (INHBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW487Ca01 | Recombinant Inhibin Binding Protein (INHBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW487Ca01 | Monoclonal Antibody to Inhibin Binding Protein (INHBP) | WB; IHC; ICC; IP. |
| PAW487Ca01 | Polyclonal Antibody to Inhibin Binding Protein (INHBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW487Ca01 | CLIA Kit for Inhibin Binding Protein (INHBP) | CLIA assay for Antigen Detection |
| ELW487Ca01 | ELISA Kit for Inhibin Binding Protein (INHBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW487Po01 | Recombinant Inhibin Binding Protein (INHBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW487Po01 | Monoclonal Antibody to Inhibin Binding Protein (INHBP) | WB; IHC; ICC; IP. |
| PAW487Po01 | Polyclonal Antibody to Inhibin Binding Protein (INHBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW487Po01 | CLIA Kit for Inhibin Binding Protein (INHBP) | CLIA assay for Antigen Detection |
| ELW487Po01 | ELISA Kit for Inhibin Binding Protein (INHBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW487Bo01 | Recombinant Inhibin Binding Protein (INHBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW487Bo01 | Monoclonal Antibody to Inhibin Binding Protein (INHBP) | WB; IHC; ICC; IP. |
| PAW487Bo01 | Polyclonal Antibody to Inhibin Binding Protein (INHBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW487Bo01 | CLIA Kit for Inhibin Binding Protein (INHBP) | CLIA assay for Antigen Detection |
| ELW487Bo01 | ELISA Kit for Inhibin Binding Protein (INHBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW487Rb01 | Recombinant Inhibin Binding Protein (INHBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW487Rb01 | Monoclonal Antibody to Inhibin Binding Protein (INHBP) | WB; IHC; ICC; IP. |
| PAW487Rb01 | Polyclonal Antibody to Inhibin Binding Protein (INHBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW487Rb01 | CLIA Kit for Inhibin Binding Protein (INHBP) | CLIA assay for Antigen Detection |
| ELW487Rb01 | ELISA Kit for Inhibin Binding Protein (INHBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW487Mo01 | Recombinant Inhibin Binding Protein (INHBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW487Mo01 | Monoclonal Antibody to Inhibin Binding Protein (INHBP) | WB; IHC; ICC; IP. |
| PAW487Mo01 | Polyclonal Antibody to Inhibin Binding Protein (INHBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW487Mo01 | CLIA Kit for Inhibin Binding Protein (INHBP) | CLIA assay for Antigen Detection |
| ELW487Mo01 | ELISA Kit for Inhibin Binding Protein (INHBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification and genomic organization of a gene coding for a new member of the cell adhesion molecule family mapping to Xq25."
Gene 214:1-6(1998) [PubMed] [Europe PMC] [Abstract]
"Cloning and expression of an immunoglobulin superfamily gene (IGSF1) in Xq25."
Genomics 48:157-162(1998) [PubMed] [Europe PMC] [Abstract]
"Expression profile of active genes in the human pituitary gland."
J. Mol. Endocrinol. 28:33-44(2002) [PubMed] [Europe PMC] [Abstract]
"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP)."
Mol. Endocrinol. 15:668-679(2001) [PubMed] [Europe PMC] [Abstract]
"Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs."
Genome Res. 12:1773-1784(2002) [PubMed] [Europe PMC] [Abstract]
"Properties of inhibin binding to betaglycan, InhBP/p120 and the activin type II receptors."
Mol. Cell. Endocrinol. 196:79-93(2002) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement."
Nat. Genet. 44:1375-1381(2012) [PubMed] [Europe PMC] [Abstract]