Insulin Like Growth Factor Binding Protein 6 (IGFBP6)
IBP6; IGF-binding protein 6
The Insulin-like growth factor binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1 (IGF-1). Insulin-like growth factor binding protein (IGFBP6) is unique among IGFBPs for its IGF-II binding specificity. IGFBP6 inhibits growth of a number of IGF-II-dependent cancers, including rhabdomyosarcoma, neuroblastoma and colon cancer. Both the N-terminal and C-terminal domains of IGFBP6 contribute to high affinity IGF binding, and the C-terminal domain appears to confer its IGF-II specificity. The three-dimensional structure of the C-domain of IGFBP6 contains a thyroglobulin type 1 fold, and the IGF-II binding site is located in the proximal half of this domain adjacent to the glycosaminoglycan binding site. IGFBP6 is a protein that is encoded by the IGFBP6 gene.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW486Hu01 | Recombinant Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW486Hu01 | Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | WB; IHC; ICC; IP. |
| PAW486Hu01 | Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW486Hu01 | CLIA Kit for Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | CLIA assay for Antigen Detection |
| ELW486Hu01 | ELISA Kit for Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW486Mu01 | Recombinant Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW486Mu01 | Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | WB; IHC; ICC; IP. |
| PAW486Mu01 | Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW486Mu01 | CLIA Kit for Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | CLIA assay for Antigen Detection |
| ELW486Mu01 | ELISA Kit for Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW486Ra01 | Recombinant Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW486Ra01 | Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | WB; IHC; ICC; IP. |
| PAW486Ra01 | Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW486Ra01 | CLIA Kit for Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | CLIA assay for Antigen Detection |
| ELW486Ra01 | ELISA Kit for Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW486Ca01 | Recombinant Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW486Ca01 | Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | WB; IHC; ICC; IP. |
| PAW486Ca01 | Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW486Ca01 | CLIA Kit for Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | CLIA assay for Antigen Detection |
| ELW486Ca01 | ELISA Kit for Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW486Po01 | Recombinant Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW486Po01 | Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | WB; IHC; ICC; IP. |
| PAW486Po01 | Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW486Po01 | CLIA Kit for Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | CLIA assay for Antigen Detection |
| ELW486Po01 | ELISA Kit for Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW486Bo01 | Recombinant Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW486Bo01 | Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | WB; IHC; ICC; IP. |
| PAW486Bo01 | Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW486Bo01 | CLIA Kit for Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | CLIA assay for Antigen Detection |
| ELW486Bo01 | ELISA Kit for Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW486Rb01 | Recombinant Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW486Rb01 | Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | WB; IHC; ICC; IP. |
| PAW486Rb01 | Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW486Rb01 | CLIA Kit for Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | CLIA assay for Antigen Detection |
| ELW486Rb01 | ELISA Kit for Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW486Mo01 | Recombinant Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW486Mo01 | Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | WB; IHC; ICC; IP. |
| PAW486Mo01 | Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW486Mo01 | CLIA Kit for Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | CLIA assay for Antigen Detection |
| ELW486Mo01 | ELISA Kit for Insulin Like Growth Factor Binding Protein 6 (IGFBP6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification and molecular cloning of two new 30-kDa insulin-like growth factor binding proteins isolated from adult human serum."
J. Biol. Chem. 266:9043-9049(1991) [PubMed] [Europe PMC] [Abstract]
"Characterization and chromosomal localization of the human insulin-like growth factor-binding protein 6 gene."
Mamm. Genome 10:376-380(1999) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Isolation and molecular cloning of insulin-like growth factor-binding protein-6."
Mol. Endocrinol. 5:938-948(1991) [PubMed] [Europe PMC] [Abstract]
"Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia."
J. Biol. Chem. 265:14892-14898(1990) [PubMed] [Europe PMC] [Abstract]
"Isolation from human cerebrospinal fluid of a new insulin-like growth factor-binding protein with a selective affinity for IGF-II."
FEBS Lett. 255:253-258(1989) [PubMed] [Europe PMC] [Abstract]
"Purification and properties of a novel insulin-like growth factor-II binding protein from transformed human fibroblasts."
J. Biol. Chem. 265:4124-4130(1990) [PubMed] [Europe PMC] [Abstract]
"A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells."
Biochem. Biophys. Res. Commun. 176:213-218(1991) [PubMed] [Europe PMC] [Abstract]
"Identification of O-glycosylation sites and partial characterization of carbohydrate structure and disulfide linkages of human insulin-like growth factor binding protein 6."
Biochemistry 37:6572-6585(1998) [PubMed] [Europe PMC] [Abstract]
"The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry."
J. Biol. Chem. 274:14587-14594(1999) [PubMed] [Europe PMC] [Abstract]
"Enrichment of glycopeptides for glycan structure and attachment site identification."
Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]