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Talin (TLN)

Talin Protein; TLN1; ILWEQ

TALIN is a high-molecular-weight cytoskeletal protein concentrated at regions of cell-substratum contactand, in lymphocytes, at cell-cell contacts.Talin-1 is a cytoskeletal protein which is concentrated in areas of cell-substratum and cell-cell contacts. This protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW483Hu01 Recombinant Talin (TLN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW483Hu01 Monoclonal Antibody to Talin (TLN) WB; IHC; ICC; IP.
PAW483Hu01 Polyclonal Antibody to Talin (TLN) WB; IHC; ICC; IF.
Assay Kits CLW483Hu01 CLIA Kit for Talin (TLN) CLIA assay for Antigen Detection
ELW483Hu01 ELISA Kit for Talin (TLN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW483Mu01 Recombinant Talin (TLN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW483Mu01 Monoclonal Antibody to Talin (TLN) WB; IHC; ICC; IP.
PAW483Mu01 Polyclonal Antibody to Talin (TLN) WB; IHC; ICC; IF.
Assay Kits CLW483Mu01 CLIA Kit for Talin (TLN) CLIA assay for Antigen Detection
ELW483Mu01 ELISA Kit for Talin (TLN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW483Ra01 Recombinant Talin (TLN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW483Ra01 Monoclonal Antibody to Talin (TLN) WB; IHC; ICC; IP.
PAW483Ra01 Polyclonal Antibody to Talin (TLN) WB; IHC; ICC; IF.
Assay Kits CLW483Ra01 CLIA Kit for Talin (TLN) CLIA assay for Antigen Detection
ELW483Ra01 ELISA Kit for Talin (TLN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW483Ca01 Recombinant Talin (TLN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW483Ca01 Monoclonal Antibody to Talin (TLN) WB; IHC; ICC; IP.
PAW483Ca01 Polyclonal Antibody to Talin (TLN) WB; IHC; ICC; IF.
Assay Kits CLW483Ca01 CLIA Kit for Talin (TLN) CLIA assay for Antigen Detection
ELW483Ca01 ELISA Kit for Talin (TLN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW483Po01 Recombinant Talin (TLN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW483Po01 Monoclonal Antibody to Talin (TLN) WB; IHC; ICC; IP.
PAW483Po01 Polyclonal Antibody to Talin (TLN) WB; IHC; ICC; IF.
Assay Kits CLW483Po01 CLIA Kit for Talin (TLN) CLIA assay for Antigen Detection
ELW483Po01 ELISA Kit for Talin (TLN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW483Bo01 Recombinant Talin (TLN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW483Bo01 Monoclonal Antibody to Talin (TLN) WB; IHC; ICC; IP.
PAW483Bo01 Polyclonal Antibody to Talin (TLN) WB; IHC; ICC; IF.
Assay Kits CLW483Bo01 CLIA Kit for Talin (TLN) CLIA assay for Antigen Detection
ELW483Bo01 ELISA Kit for Talin (TLN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW483Rb01 Recombinant Talin (TLN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW483Rb01 Monoclonal Antibody to Talin (TLN) WB; IHC; ICC; IP.
PAW483Rb01 Polyclonal Antibody to Talin (TLN) WB; IHC; ICC; IF.
Assay Kits CLW483Rb01 CLIA Kit for Talin (TLN) CLIA assay for Antigen Detection
ELW483Rb01 ELISA Kit for Talin (TLN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW483Mo01 Recombinant Talin (TLN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW483Mo01 Monoclonal Antibody to Talin (TLN) WB; IHC; ICC; IP.
PAW483Mo01 Polyclonal Antibody to Talin (TLN) WB; IHC; ICC; IF.
Assay Kits CLW483Mo01 CLIA Kit for Talin (TLN) CLIA assay for Antigen Detection
ELW483Mo01 ELISA Kit for Talin (TLN) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

, Submitted (NOV-2005) to UniProtKB

"Molecular interactions of N-RAP, a nebulin-related protein of striated muscle myotendon junctions and intercalated disks."
Biochemistry 38:6135-6143(1999) [PubMed] [Europe PMC] [Abstract]

"Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions."
Nature 420:89-93(2002) [PubMed] [Europe PMC] [Abstract]

"Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha."
J. Biol. Chem. 278:6567-6574(2003) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"Identification of a repeated domain within mammalian alpha-synemin that interacts directly with talin."
Exp. Cell Res. 314:1839-1849(2008) [PubMed] [Europe PMC] [Abstract]

"Phosphoproteome of resting human platelets."
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
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"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
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"Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition."
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"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
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"HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells."
Cell Host Microbe 16:201-214(2014) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structural basis for amplifying vinculin activation by talin."
J. Biol. Chem. 279:27667-27678(2004) [PubMed] [Europe PMC] [Abstract]