Platelet/Endothelial Cell Adhesion Molecule (PECAM1)

CD31; EndoCAM; GPIIA'; PECA1

SPN	W438
HGNC	8823
MGI	97537
PubMed	7956830
RGD	61927
UniProt	P16284
Wiki	CD31

CD31 is a cluster of differentiation molecule. It is also called PECAM-1 for platelet endothelial cell adhesion molecule. It plays a key role in removing aged neutrophils from the body. Macrophages palpate any passing neutrophil and have to decide whether the cell is healthy or has to be ingested. In humans, the gene encoding CD-31 is found on chromosome 17.

If a neutrophil is dying, it will have phosphatidyl serine in its plasma membrane. Both the neutrophil and the macrophage express CD-31 on their membranes, and, during the testing process, these CD-31 molecules bind the two cells together. If the neutrophil is healthy, it will now fire a signal to the macrophage, and the CD-31 molecules will detach. The neutrophil is now free.

Reference

"Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen."
J. Exp. Med. 171:2147-2152(1990) [PubMed] [Europe PMC] [Abstract]

"Molecular characterization and functional analysis of the leukocyte surface protein CD31."
J. Immunol. 145:3889-3897(1990) [PubMed] [Europe PMC] [Abstract]

"PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily."
Science 247:1219-1222(1990) [PubMed] [Europe PMC] [Abstract]

"Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule."
J. Cell Biol. 114:1059-1068(1991) [PubMed] [Europe PMC] [Abstract]

"Organization of the gene for human platelet/endothelial cell adhesion molecule-1 shows alternatively spliced isoforms and a functionally complex cytoplasmic domain."
Blood 84:4028-4037(1994) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of PECAM-1 in solid tumor cells and its potential involvement in tumor cell adhesion to endothelium."
J. Biol. Chem. 268:22883-22894(1993) [PubMed] [Europe PMC] [Abstract]

"Tyrosine residue in exon 14 of the cytoplasmic domain of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) regulates ligand binding specificity."
J. Cell Biol. 138:1425-1435(1997) [PubMed] [Europe PMC] [Abstract]

"Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment."
Nature 418:200-203(2002) [PubMed] [Europe PMC] [Abstract]

"Tissue-specific distributions of alternatively spliced human PECAM-1 isoforms."
Am. J. Physiol. 284:H1008-H1017(2003) [PubMed] [Europe PMC] [Abstract]

"Palmitoylation at Cys595 is essential for PECAM-1 localisation into membrane microdomains and for efficient PECAM-1-mediated cytoprotection."
Thromb. Haemost. 96:756-766(2006) [PubMed] [Europe PMC] [Abstract]

"Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1."
Biochemistry 47:9029-9039(2008) [PubMed] [Europe PMC] [Abstract]

"Mechanotransduction in an extracted cell model: Fyn drives stretch- and flow-elicited PECAM-1 phosphorylation."
J. Cell Biol. 182:753-763(2008) [PubMed] [Europe PMC] [Abstract]

"An alternatively spliced isoform of PECAM-1 is expressed at high levels in human and murine tissues, and suggests a novel role for the C-terminus of PECAM-1 in cytoprotective signaling."
J. Cell Sci. 121:1235-1242(2008) [PubMed] [Europe PMC] [Abstract]

"Phosphoproteome of resting human platelets."
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

"A novel and critical role for tyrosine 663 in platelet endothelial cell adhesion molecule-1 trafficking and transendothelial migration."
J. Immunol. 182:5041-5051(2009) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases."
Circ. Res. 110:1336-1344(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Polymorphism of adhesion molecule CD31 and its role in acute graft-versus-host disease."
N. Engl. J. Med. 334:286-291(1996) [PubMed] [Europe PMC] [Abstract]

"Codon 125 polymorphism of CD31 and susceptibility to malaria."
Am. J. Trop. Med. Hyg. 65:736-737(2001) [PubMed] [Europe PMC] [Abstract]