Gelsolin (GS)
GSN; AGEL; ADF; Brevin; Gelsolin Amyloidosis,Finnish Type; Actin-depolymerizing factor
Gelsolin is an actin-regulatory protein that modulates actin assembly and disassembly, and is believed to regulate cell motility in vivo through modulation of the actin network. In addition to its actin-regulatory function, gelsolin has also been proposed to affect cell growth.It is first isolated from rabbit lung macrophages as a modulator of the cytoplasmic actin gel−sol transformation. Gelsolin can sever actin filaments and cap the fast-growing ends of the filaments in vitro; this promotes actin disassembly. Gelsolin also has the ability to nucleate actin polymerization. These functions are activated by Ca2 and inhibited by polyphosphoinositides (PPIs). Such observations have led to the view that gelsolin regulates actin reorganization in response to changes in the concentrations of Ca2 and PPIs in living cells.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW430Hu01 | Recombinant Gelsolin (GS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW430Hu01 | Monoclonal Antibody to Gelsolin (GS) | WB; IHC; ICC; IP. |
| PAW430Hu01 | Polyclonal Antibody to Gelsolin (GS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW430Hu01 | CLIA Kit for Gelsolin (GS) | CLIA assay for Antigen Detection |
| ELW430Hu01 | ELISA Kit for Gelsolin (GS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW430Mu01 | Recombinant Gelsolin (GS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW430Mu01 | Monoclonal Antibody to Gelsolin (GS) | WB; IHC; ICC; IP. |
| PAW430Mu01 | Polyclonal Antibody to Gelsolin (GS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW430Mu01 | CLIA Kit for Gelsolin (GS) | CLIA assay for Antigen Detection |
| ELW430Mu01 | ELISA Kit for Gelsolin (GS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW430Ra01 | Recombinant Gelsolin (GS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW430Ra01 | Monoclonal Antibody to Gelsolin (GS) | WB; IHC; ICC; IP. |
| PAW430Ra01 | Polyclonal Antibody to Gelsolin (GS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW430Ra01 | CLIA Kit for Gelsolin (GS) | CLIA assay for Antigen Detection |
| ELW430Ra01 | ELISA Kit for Gelsolin (GS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW430Ca01 | Recombinant Gelsolin (GS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW430Ca01 | Monoclonal Antibody to Gelsolin (GS) | WB; IHC; ICC; IP. |
| PAW430Ca01 | Polyclonal Antibody to Gelsolin (GS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW430Ca01 | CLIA Kit for Gelsolin (GS) | CLIA assay for Antigen Detection |
| ELW430Ca01 | ELISA Kit for Gelsolin (GS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW430Po01 | Recombinant Gelsolin (GS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW430Po01 | Monoclonal Antibody to Gelsolin (GS) | WB; IHC; ICC; IP. |
| PAW430Po01 | Polyclonal Antibody to Gelsolin (GS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW430Po01 | CLIA Kit for Gelsolin (GS) | CLIA assay for Antigen Detection |
| ELW430Po01 | ELISA Kit for Gelsolin (GS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW430Bo01 | Recombinant Gelsolin (GS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW430Bo01 | Monoclonal Antibody to Gelsolin (GS) | WB; IHC; ICC; IP. |
| PAW430Bo01 | Polyclonal Antibody to Gelsolin (GS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW430Bo01 | CLIA Kit for Gelsolin (GS) | CLIA assay for Antigen Detection |
| ELW430Bo01 | ELISA Kit for Gelsolin (GS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW430Rb01 | Recombinant Gelsolin (GS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW430Rb01 | Monoclonal Antibody to Gelsolin (GS) | WB; IHC; ICC; IP. |
| PAW430Rb01 | Polyclonal Antibody to Gelsolin (GS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW430Rb01 | CLIA Kit for Gelsolin (GS) | CLIA assay for Antigen Detection |
| ELW430Rb01 | ELISA Kit for Gelsolin (GS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW430Mo01 | Recombinant Gelsolin (GS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW430Mo01 | Monoclonal Antibody to Gelsolin (GS) | WB; IHC; ICC; IP. |
| PAW430Mo01 | Polyclonal Antibody to Gelsolin (GS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW430Mo01 | CLIA Kit for Gelsolin (GS) | CLIA assay for Antigen Detection |
| ELW430Mo01 | ELISA Kit for Gelsolin (GS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain."
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FEBS Lett. 401:89-94(1997) [PubMed] [Europe PMC] [Abstract]
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Nature 464:1048-1051(2010) [PubMed] [Europe PMC] [Abstract]
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J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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Nature 364:685-692(1993) [PubMed] [Europe PMC] [Abstract]
"Spectroscopic studies of a phosphoinositide-binding peptide from gelsolin: behavior in solutions of mixed solvent and anionic micelles."
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J. Mol. Biol. 357:773-782(2006) [PubMed] [Europe PMC] [Abstract]
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Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]