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Fibrillin 3 (FBN3)

SPN W422
HGNC 18794
PubMed 20970500
UniProt Q75N90
Wiki Fibrillin

More recently, fibrillin-3 was described and is believed to be located mainly in the brain. Along with the brain, fibrillin 1 has been localized in the gonads and ovaries of field mice.

Fibrillins, such as FBN3, are extracellular matrix macromolecules that perform architectural functions in most connective tissues. Fibrillins assemble into microfibrils that can be identified ultrastructurally as uniform, small-diameter fibrils.By sequencing clones obtained from a size-fractionated fetal brain cDNA library, Nagase et al. cloned FBN3, which they also called KIAA1776. The deduced 2,816-amino acid protein has an N-terminal signal sequence, numerous EGF-like repeats, and several 8-cysteine modules called TB domains. FBN3 shares more than 60% amino acid identity with FBN1, FBN2, and mouse Fbn2.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW422Hu01 Recombinant Fibrillin 3 (FBN3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW422Hu01 Monoclonal Antibody to Fibrillin 3 (FBN3) WB; IHC; ICC; IP.
PAW422Hu01 Polyclonal Antibody to Fibrillin 3 (FBN3) WB; IHC; ICC; IF.
Assay Kits CLW422Hu01 CLIA Kit for Fibrillin 3 (FBN3) CLIA assay for Antigen Detection
ELW422Hu01 ELISA Kit for Fibrillin 3 (FBN3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW422Mu01 Recombinant Fibrillin 3 (FBN3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW422Mu01 Monoclonal Antibody to Fibrillin 3 (FBN3) WB; IHC; ICC; IP.
PAW422Mu01 Polyclonal Antibody to Fibrillin 3 (FBN3) WB; IHC; ICC; IF.
Assay Kits CLW422Mu01 CLIA Kit for Fibrillin 3 (FBN3) CLIA assay for Antigen Detection
ELW422Mu01 ELISA Kit for Fibrillin 3 (FBN3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW422Ra01 Recombinant Fibrillin 3 (FBN3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW422Ra01 Monoclonal Antibody to Fibrillin 3 (FBN3) WB; IHC; ICC; IP.
PAW422Ra01 Polyclonal Antibody to Fibrillin 3 (FBN3) WB; IHC; ICC; IF.
Assay Kits CLW422Ra01 CLIA Kit for Fibrillin 3 (FBN3) CLIA assay for Antigen Detection
ELW422Ra01 ELISA Kit for Fibrillin 3 (FBN3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW422Ca01 Recombinant Fibrillin 3 (FBN3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW422Ca01 Monoclonal Antibody to Fibrillin 3 (FBN3) WB; IHC; ICC; IP.
PAW422Ca01 Polyclonal Antibody to Fibrillin 3 (FBN3) WB; IHC; ICC; IF.
Assay Kits CLW422Ca01 CLIA Kit for Fibrillin 3 (FBN3) CLIA assay for Antigen Detection
ELW422Ca01 ELISA Kit for Fibrillin 3 (FBN3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW422Po01 Recombinant Fibrillin 3 (FBN3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW422Po01 Monoclonal Antibody to Fibrillin 3 (FBN3) WB; IHC; ICC; IP.
PAW422Po01 Polyclonal Antibody to Fibrillin 3 (FBN3) WB; IHC; ICC; IF.
Assay Kits CLW422Po01 CLIA Kit for Fibrillin 3 (FBN3) CLIA assay for Antigen Detection
ELW422Po01 ELISA Kit for Fibrillin 3 (FBN3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW422Bo01 Recombinant Fibrillin 3 (FBN3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW422Bo01 Monoclonal Antibody to Fibrillin 3 (FBN3) WB; IHC; ICC; IP.
PAW422Bo01 Polyclonal Antibody to Fibrillin 3 (FBN3) WB; IHC; ICC; IF.
Assay Kits CLW422Bo01 CLIA Kit for Fibrillin 3 (FBN3) CLIA assay for Antigen Detection
ELW422Bo01 ELISA Kit for Fibrillin 3 (FBN3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW422Rb01 Recombinant Fibrillin 3 (FBN3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW422Rb01 Monoclonal Antibody to Fibrillin 3 (FBN3) WB; IHC; ICC; IP.
PAW422Rb01 Polyclonal Antibody to Fibrillin 3 (FBN3) WB; IHC; ICC; IF.
Assay Kits CLW422Rb01 CLIA Kit for Fibrillin 3 (FBN3) CLIA assay for Antigen Detection
ELW422Rb01 ELISA Kit for Fibrillin 3 (FBN3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW422Mo01 Recombinant Fibrillin 3 (FBN3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW422Mo01 Monoclonal Antibody to Fibrillin 3 (FBN3) WB; IHC; ICC; IP.
PAW422Mo01 Polyclonal Antibody to Fibrillin 3 (FBN3) WB; IHC; ICC; IF.
Assay Kits CLW422Mo01 CLIA Kit for Fibrillin 3 (FBN3) CLIA assay for Antigen Detection
ELW422Mo01 ELISA Kit for Fibrillin 3 (FBN3) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Differential expression of fibrillin-3 adds to microfibril variety in human and avian, but not rodent, connective tissues."
Genomics 83:461-472(2004) [PubMed] [Europe PMC] [Abstract]

"Three novel mutations of the fibrillin-1 gene and ten single nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome patients."
J. Hum. Genet. 49:404-407(2004) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

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