Interleukin 23 (IL23)
IL23A; P19; IL23P19; SGRF; Interleukin-23 subunit alpha
Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Rat p19 cDNA encodes a 189 amino acid residue (aa) precursor protein with a putative 19 aa signal peptide and 170 aa mature protein. Rat and mouse p19 share 70% aa sequence identity. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW419Hu01 | Recombinant Interleukin 23 (IL23) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW419Hu01 | Monoclonal Antibody to Interleukin 23 (IL23) | WB; IHC; ICC; IP. |
| PAW419Hu01 | Polyclonal Antibody to Interleukin 23 (IL23) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW419Hu01 | CLIA Kit for Interleukin 23 (IL23) | CLIA assay for Antigen Detection |
| ELW419Hu01 | ELISA Kit for Interleukin 23 (IL23) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW419Mu01 | Recombinant Interleukin 23 (IL23) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW419Mu01 | Monoclonal Antibody to Interleukin 23 (IL23) | WB; IHC; ICC; IP. |
| PAW419Mu01 | Polyclonal Antibody to Interleukin 23 (IL23) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW419Mu01 | CLIA Kit for Interleukin 23 (IL23) | CLIA assay for Antigen Detection |
| ELW419Mu01 | ELISA Kit for Interleukin 23 (IL23) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW419Ra01 | Recombinant Interleukin 23 (IL23) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW419Ra01 | Monoclonal Antibody to Interleukin 23 (IL23) | WB; IHC; ICC; IP. |
| PAW419Ra01 | Polyclonal Antibody to Interleukin 23 (IL23) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW419Ra01 | CLIA Kit for Interleukin 23 (IL23) | CLIA assay for Antigen Detection |
| ELW419Ra01 | ELISA Kit for Interleukin 23 (IL23) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW419Ca01 | Recombinant Interleukin 23 (IL23) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW419Ca01 | Monoclonal Antibody to Interleukin 23 (IL23) | WB; IHC; ICC; IP. |
| PAW419Ca01 | Polyclonal Antibody to Interleukin 23 (IL23) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW419Ca01 | CLIA Kit for Interleukin 23 (IL23) | CLIA assay for Antigen Detection |
| ELW419Ca01 | ELISA Kit for Interleukin 23 (IL23) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW419Po01 | Recombinant Interleukin 23 (IL23) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW419Po01 | Monoclonal Antibody to Interleukin 23 (IL23) | WB; IHC; ICC; IP. |
| PAW419Po01 | Polyclonal Antibody to Interleukin 23 (IL23) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW419Po01 | CLIA Kit for Interleukin 23 (IL23) | CLIA assay for Antigen Detection |
| ELW419Po01 | ELISA Kit for Interleukin 23 (IL23) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW419Bo01 | Recombinant Interleukin 23 (IL23) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW419Bo01 | Monoclonal Antibody to Interleukin 23 (IL23) | WB; IHC; ICC; IP. |
| PAW419Bo01 | Polyclonal Antibody to Interleukin 23 (IL23) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW419Bo01 | CLIA Kit for Interleukin 23 (IL23) | CLIA assay for Antigen Detection |
| ELW419Bo01 | ELISA Kit for Interleukin 23 (IL23) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW419Rb01 | Recombinant Interleukin 23 (IL23) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW419Rb01 | Monoclonal Antibody to Interleukin 23 (IL23) | WB; IHC; ICC; IP. |
| PAW419Rb01 | Polyclonal Antibody to Interleukin 23 (IL23) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW419Rb01 | CLIA Kit for Interleukin 23 (IL23) | CLIA assay for Antigen Detection |
| ELW419Rb01 | ELISA Kit for Interleukin 23 (IL23) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW419Mo01 | Recombinant Interleukin 23 (IL23) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW419Mo01 | Monoclonal Antibody to Interleukin 23 (IL23) | WB; IHC; ICC; IP. |
| PAW419Mo01 | Polyclonal Antibody to Interleukin 23 (IL23) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW419Mo01 | CLIA Kit for Interleukin 23 (IL23) | CLIA assay for Antigen Detection |
| ELW419Mo01 | ELISA Kit for Interleukin 23 (IL23) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12."
Immunity 13:715-725(2000) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R."
J. Immunol. 168:5699-5708(2002) [PubMed] [Europe PMC] [Abstract]
"Regulation of virus-induced IL-12 and IL-23 expression in human macrophages."
J. Immunol. 169:5673-5678(2002) [PubMed] [Europe PMC] [Abstract]
"Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development."
Eur. J. Immunol. 34:1371-1380(2004) [PubMed] [Europe PMC] [Abstract]
"Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway."
Blood 105:1582-1589(2005) [PubMed] [Europe PMC] [Abstract]
"Bordetella pertussis-infected human monocyte-derived dendritic cells undergo maturation and induce Th1 polarization and interleukin-23 expression."
Infect. Immun. 73:1590-1597(2005) [PubMed] [Europe PMC] [Abstract]
"Preferential production of the IL-12(p40)/IL-23(p19) heterodimer by dendritic cells from human newborns."
Eur. J. Immunol. 36:21-26(2006) [PubMed] [Europe PMC] [Abstract]
"In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin."
J. Immunol. 176:1908-1915(2006) [PubMed] [Europe PMC] [Abstract]
"IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production."
J. Immunol. 176:7768-7774(2006) [PubMed] [Europe PMC] [Abstract]
"IL-23 promotes tumour incidence and growth."
Nature 442:461-465(2006) [PubMed] [Europe PMC] [Abstract]
"The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12."
J. Mol. Biol. 382:931-941(2008) [PubMed] [Europe PMC] [Abstract]