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Complement Component 4a (C4a)

C4; C4S; CO4; CPAMD2; RG; C4A; C4F; CH; CPAMD3; C4(Rodgers Blood Group); Acidic C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2

Complement C4-A is the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW414Hu01 Recombinant Complement Component 4a (C4a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW414Hu01 Monoclonal Antibody to Complement Component 4a (C4a) WB; IHC; ICC; IP.
PAW414Hu01 Polyclonal Antibody to Complement Component 4a (C4a) WB; IHC; ICC; IF.
Assay Kits CLW414Hu01 CLIA Kit for Complement Component 4a (C4a) CLIA assay for Antigen Detection
ELW414Hu01 ELISA Kit for Complement Component 4a (C4a) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW414Mu01 Recombinant Complement Component 4a (C4a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW414Mu01 Monoclonal Antibody to Complement Component 4a (C4a) WB; IHC; ICC; IP.
PAW414Mu01 Polyclonal Antibody to Complement Component 4a (C4a) WB; IHC; ICC; IF.
Assay Kits CLW414Mu01 CLIA Kit for Complement Component 4a (C4a) CLIA assay for Antigen Detection
ELW414Mu01 ELISA Kit for Complement Component 4a (C4a) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW414Ra01 Recombinant Complement Component 4a (C4a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW414Ra01 Monoclonal Antibody to Complement Component 4a (C4a) WB; IHC; ICC; IP.
PAW414Ra01 Polyclonal Antibody to Complement Component 4a (C4a) WB; IHC; ICC; IF.
Assay Kits CLW414Ra01 CLIA Kit for Complement Component 4a (C4a) CLIA assay for Antigen Detection
ELW414Ra01 ELISA Kit for Complement Component 4a (C4a) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW414Ca01 Recombinant Complement Component 4a (C4a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW414Ca01 Monoclonal Antibody to Complement Component 4a (C4a) WB; IHC; ICC; IP.
PAW414Ca01 Polyclonal Antibody to Complement Component 4a (C4a) WB; IHC; ICC; IF.
Assay Kits CLW414Ca01 CLIA Kit for Complement Component 4a (C4a) CLIA assay for Antigen Detection
ELW414Ca01 ELISA Kit for Complement Component 4a (C4a) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW414Po01 Recombinant Complement Component 4a (C4a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW414Po01 Monoclonal Antibody to Complement Component 4a (C4a) WB; IHC; ICC; IP.
PAW414Po01 Polyclonal Antibody to Complement Component 4a (C4a) WB; IHC; ICC; IF.
Assay Kits CLW414Po01 CLIA Kit for Complement Component 4a (C4a) CLIA assay for Antigen Detection
ELW414Po01 ELISA Kit for Complement Component 4a (C4a) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW414Bo01 Recombinant Complement Component 4a (C4a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW414Bo01 Monoclonal Antibody to Complement Component 4a (C4a) WB; IHC; ICC; IP.
PAW414Bo01 Polyclonal Antibody to Complement Component 4a (C4a) WB; IHC; ICC; IF.
Assay Kits CLW414Bo01 CLIA Kit for Complement Component 4a (C4a) CLIA assay for Antigen Detection
ELW414Bo01 ELISA Kit for Complement Component 4a (C4a) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW414Rb01 Recombinant Complement Component 4a (C4a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW414Rb01 Monoclonal Antibody to Complement Component 4a (C4a) WB; IHC; ICC; IP.
PAW414Rb01 Polyclonal Antibody to Complement Component 4a (C4a) WB; IHC; ICC; IF.
Assay Kits CLW414Rb01 CLIA Kit for Complement Component 4a (C4a) CLIA assay for Antigen Detection
ELW414Rb01 ELISA Kit for Complement Component 4a (C4a) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW414Mo01 Recombinant Complement Component 4a (C4a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW414Mo01 Monoclonal Antibody to Complement Component 4a (C4a) WB; IHC; ICC; IP.
PAW414Mo01 Polyclonal Antibody to Complement Component 4a (C4a) WB; IHC; ICC; IF.
Assay Kits CLW414Mo01 CLIA Kit for Complement Component 4a (C4a) CLIA assay for Antigen Detection
ELW414Mo01 ELISA Kit for Complement Component 4a (C4a) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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"Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, Slp and C4."
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"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
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"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
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"Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans."
Am. J. Hum. Genet. 80:1037-1054(2007) [PubMed] [Europe PMC] [Abstract]

"Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
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"The coding sequence of the hemolytically inactive C4A6 allotype of human complement component C4 reveals that a single arginine to tryptophan substitution at beta-chain residue 458 is the likely cause of the defect."
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