Follistatin (FS)
FST; Activin-binding protein
Follistatin was first identified as a follicle-stimulating hormone inhibiting substance present in ovarian follicular fluid. It has since been shown to be a multifunctional regulatory protein exerting a majority of its effects via neutralization of activin. FS is a monomeric binding protein that regulates activin activity by forming an inactive complex. FS plays a role as a tissue regulator in the gonad, pituitary gland,pregnancy membranes, vasculature, and liver. It is also essential for normal development, as FS-knockout mice die shortly after birth with a range of defects including insufficient muscle development and skeletal abnormalities. Alternative splicing events, proteolytic cleavage and variable glycosylation lead to a vast array of possible FS isoforms found within various biological fluids.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW412Hu01 | Recombinant Follistatin (FS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW412Hu01 | Monoclonal Antibody to Follistatin (FS) | WB; IHC; ICC; IP. |
| PAW412Hu01 | Polyclonal Antibody to Follistatin (FS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW412Hu01 | CLIA Kit for Follistatin (FS) | CLIA assay for Antigen Detection |
| ELW412Hu01 | ELISA Kit for Follistatin (FS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW412Mu01 | Recombinant Follistatin (FS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW412Mu01 | Monoclonal Antibody to Follistatin (FS) | WB; IHC; ICC; IP. |
| PAW412Mu01 | Polyclonal Antibody to Follistatin (FS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW412Mu01 | CLIA Kit for Follistatin (FS) | CLIA assay for Antigen Detection |
| ELW412Mu01 | ELISA Kit for Follistatin (FS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW412Ra01 | Recombinant Follistatin (FS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW412Ra01 | Monoclonal Antibody to Follistatin (FS) | WB; IHC; ICC; IP. |
| PAW412Ra01 | Polyclonal Antibody to Follistatin (FS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW412Ra01 | CLIA Kit for Follistatin (FS) | CLIA assay for Antigen Detection |
| ELW412Ra01 | ELISA Kit for Follistatin (FS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW412Ca01 | Recombinant Follistatin (FS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW412Ca01 | Monoclonal Antibody to Follistatin (FS) | WB; IHC; ICC; IP. |
| PAW412Ca01 | Polyclonal Antibody to Follistatin (FS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW412Ca01 | CLIA Kit for Follistatin (FS) | CLIA assay for Antigen Detection |
| ELW412Ca01 | ELISA Kit for Follistatin (FS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW412Po01 | Recombinant Follistatin (FS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW412Po01 | Monoclonal Antibody to Follistatin (FS) | WB; IHC; ICC; IP. |
| PAW412Po01 | Polyclonal Antibody to Follistatin (FS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW412Po01 | CLIA Kit for Follistatin (FS) | CLIA assay for Antigen Detection |
| ELW412Po01 | ELISA Kit for Follistatin (FS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW412Bo01 | Recombinant Follistatin (FS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW412Bo01 | Monoclonal Antibody to Follistatin (FS) | WB; IHC; ICC; IP. |
| PAW412Bo01 | Polyclonal Antibody to Follistatin (FS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW412Bo01 | CLIA Kit for Follistatin (FS) | CLIA assay for Antigen Detection |
| ELW412Bo01 | ELISA Kit for Follistatin (FS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW412Rb01 | Recombinant Follistatin (FS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW412Rb01 | Monoclonal Antibody to Follistatin (FS) | WB; IHC; ICC; IP. |
| PAW412Rb01 | Polyclonal Antibody to Follistatin (FS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW412Rb01 | CLIA Kit for Follistatin (FS) | CLIA assay for Antigen Detection |
| ELW412Rb01 | ELISA Kit for Follistatin (FS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW412Mo01 | Recombinant Follistatin (FS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW412Mo01 | Monoclonal Antibody to Follistatin (FS) | WB; IHC; ICC; IP. |
| PAW412Mo01 | Polyclonal Antibody to Follistatin (FS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW412Mo01 | CLIA Kit for Follistatin (FS) | CLIA assay for Antigen Detection |
| ELW412Mo01 | ELISA Kit for Follistatin (FS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Primary structure of the human follistatin precursor and its genomic organization."
Proc. Natl. Acad. Sci. U.S.A. 85:4218-4222(1988) [PubMed] [Europe PMC] [Abstract]
"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
"Differential distribution of follistatin isoforms: application of a new FS315-specific immunoassay."
J. Clin. Endocrinol. Metab. 89:5067-5075(2004) [PubMed] [Europe PMC] [Abstract]
"The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding."
Dev. Cell 9:535-543(2005) [PubMed] [Europe PMC] [Abstract]
"Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions."
J. Biol. Chem. 282:15930-15939(2007) [PubMed] [Europe PMC] [Abstract]
"The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding."
EMBO J. 28:2662-2676(2009) [PubMed] [Europe PMC] [Abstract]