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Sex Hormone Binding Globulin (SHBG)

ABP; TEBG; SBP; Sex steroid-binding protein; Testis-specific androgen-binding protein; Testosterone-estradiol-binding globulin; Testosterone-estrogen-binding globulin

SHBG is a glycoprotein that binds to sex hormones, specifically testosterone and estradiol. Other steroid hormones such as progesterone, cortisol, and other corticosteroids are bound by transcortin. These sex hormones circulate in the bloodstream, bound mostly to SHBG and to some degree bound to serum albumin. Only a small fraction is unbound, or "free," and thus biologically active and able to enter a cell and activate its receptor. The SHBG inhibits the function of these hormones. Thus bioavailability of sex hormones is influenced by the level of SHBG. SHBG is produced by the liver cells and is released into the bloodstream. Other sites that produce SHBG are the brain, uterus, and placenta and vagina. In addition SHBG is produced by the testes; testes-produced SHBG is also called androgen-binding protein.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW407Hu01 Recombinant Sex Hormone Binding Globulin (SHBG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW407Hu01 Monoclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IP.
PAW407Hu01 Polyclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IF.
Assay Kits CLW407Hu01 CLIA Kit for Sex Hormone Binding Globulin (SHBG) CLIA assay for Antigen Detection
ELW407Hu01 ELISA Kit for Sex Hormone Binding Globulin (SHBG) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW407Mu01 Recombinant Sex Hormone Binding Globulin (SHBG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW407Mu01 Monoclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IP.
PAW407Mu01 Polyclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IF.
Assay Kits CLW407Mu01 CLIA Kit for Sex Hormone Binding Globulin (SHBG) CLIA assay for Antigen Detection
ELW407Mu01 ELISA Kit for Sex Hormone Binding Globulin (SHBG) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW407Ra01 Recombinant Sex Hormone Binding Globulin (SHBG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW407Ra01 Monoclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IP.
PAW407Ra01 Polyclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IF.
Assay Kits CLW407Ra01 CLIA Kit for Sex Hormone Binding Globulin (SHBG) CLIA assay for Antigen Detection
ELW407Ra01 ELISA Kit for Sex Hormone Binding Globulin (SHBG) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW407Ca01 Recombinant Sex Hormone Binding Globulin (SHBG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW407Ca01 Monoclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IP.
PAW407Ca01 Polyclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IF.
Assay Kits CLW407Ca01 CLIA Kit for Sex Hormone Binding Globulin (SHBG) CLIA assay for Antigen Detection
ELW407Ca01 ELISA Kit for Sex Hormone Binding Globulin (SHBG) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW407Po01 Recombinant Sex Hormone Binding Globulin (SHBG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW407Po01 Monoclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IP.
PAW407Po01 Polyclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IF.
Assay Kits CLW407Po01 CLIA Kit for Sex Hormone Binding Globulin (SHBG) CLIA assay for Antigen Detection
ELW407Po01 ELISA Kit for Sex Hormone Binding Globulin (SHBG) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW407Bo01 Recombinant Sex Hormone Binding Globulin (SHBG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW407Bo01 Monoclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IP.
PAW407Bo01 Polyclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IF.
Assay Kits CLW407Bo01 CLIA Kit for Sex Hormone Binding Globulin (SHBG) CLIA assay for Antigen Detection
ELW407Bo01 ELISA Kit for Sex Hormone Binding Globulin (SHBG) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW407Rb01 Recombinant Sex Hormone Binding Globulin (SHBG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW407Rb01 Monoclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IP.
PAW407Rb01 Polyclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IF.
Assay Kits CLW407Rb01 CLIA Kit for Sex Hormone Binding Globulin (SHBG) CLIA assay for Antigen Detection
ELW407Rb01 ELISA Kit for Sex Hormone Binding Globulin (SHBG) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW407Mo01 Recombinant Sex Hormone Binding Globulin (SHBG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW407Mo01 Monoclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IP.
PAW407Mo01 Polyclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IF.
Assay Kits CLW407Mo01 CLIA Kit for Sex Hormone Binding Globulin (SHBG) CLIA assay for Antigen Detection
ELW407Mo01 ELISA Kit for Sex Hormone Binding Globulin (SHBG) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Characterization of the human sex hormone binding globulin (SHBG) gene and demonstration of two transcripts in both liver and testis."
Nucleic Acids Res. 17:9245-9258(1989) [PubMed] [Europe PMC] [Abstract]

"The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs."
Mol. Endocrinol. 3:1869-1876(1989) [PubMed] [Europe PMC] [Abstract]

"PCR isolation and cloning of novel splice variant mRNAs from known drug target genes."
Genomics 83:566-571(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The cDNA-deduced primary structure of human sex hormone-binding globulin and location of its steroid-binding domain."
FEBS Lett. 215:100-104(1987) [PubMed] [Europe PMC] [Abstract]

"A cDNA coding for human sex hormone binding globulin. Homology to vitamin K-dependent protein S."
FEBS Lett. 220:129-135(1987) [PubMed] [Europe PMC] [Abstract]

"Characterization of a cDNA coding for sex steroid-binding protein of human plasma."
FEBS Lett. 219:405-409(1987) [PubMed] [Europe PMC] [Abstract]

"Physicochemical characteristics of human sex hormone binding globulin: evidence for two identical subunits."
J. Steroid Biochem. 24:815-824(1986) [PubMed] [Europe PMC] [Abstract]

"Amino acid sequence of the sex steroid binding protein of human blood plasma."
Biochemistry 25:7584-7590(1986) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Molecular analyses of a human sex hormone-binding globulin variant: evidence for an additional carbohydrate chain."
J. Clin. Endocrinol. Metab. 75:1066-1070(1992) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain."
EMBO J. 19:504-512(2000) [PubMed] [Europe PMC] [Abstract]

"Steroid ligands bind human sex hormone-binding globulin in specific orientations and produce distinct changes in protein conformation."
J. Biol. Chem. 277:32086-32093(2002) [PubMed] [Europe PMC] [Abstract]

"Molecular characterization of a genetic variant of the steroid hormone-binding globulin gene in heterozygous subjects."
J. Clin. Endocrinol. Metab. 80:1253-1256(1995) [PubMed] [Europe PMC] [Abstract]

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

Erratum
Nat. Genet. 23:373-373(1999)