Matrix Metalloproteinase 12 (MMP12)

MME; HME; ME; Macrophage Metalloelastase; Macrophage Elastase

SPN	W402
HGNC	7158
MGI	97005
PubMed	15723202
RGD	620195
UniProt	P39900
Wiki	MMP12

Matrix metallopeptidase 12 is part of a cluster of MMP genes which localize to chromosome 11q22.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema.

Reference

"Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages."
J. Biol. Chem. 268:23824-23829(1993) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase."
J. Biol. Chem. 272:12189-12194(1997) [PubMed] [Europe PMC] [Abstract]

"Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure."
J. Mol. Biol. 312:731-742(2001) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor."
J. Mol. Biol. 312:743-751(2001) [PubMed] [Europe PMC] [Abstract]