Early Growth Response Protein 1 (EGR1)

Zif268; AT225; G0S30; KROX24; NGFI-A; TIS8; ZIF-268; ZNF225; NGFIA; TIS8; ZENK; Nerve Growth Factor-Induced Protein A; Transcription Factor ETR103; Zinc Finger Protein 225

SPN	W389
HGNC	3238
MGI	95295
PubMed	9109500
RGD	2544
UniProt	P18146
Wiki	EGR1

Zif268 is a mammalian transcription factor that is now officially known as Egr1.It was originally discovered in mouse. The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentiation and mitogenesis. Studies suggest this is a tumor suppressor gene.The DNA binding domain of Zif268 consists of three zinc finger domains of the Cys2His2 type. The amino acid structure of the Zif268 zinc finger domain is given in this table, using the single letter amino acid code. The fingers 1 to 3 are indicated by f1 - f3. The residues marked 'x' are not part of the zinc fingers, but rather serve to connect them all together.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW389Hu01	Recombinant Early Growth Response Protein 1 (EGR1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW389Hu01	Monoclonal Antibody to Early Growth Response Protein 1 (EGR1)	WB; IHC; ICC; IP.
Antibodies	PAW389Hu01	Polyclonal Antibody to Early Growth Response Protein 1 (EGR1)	WB; IHC; ICC; IF.
Assay Kits	CLW389Hu01	CLIA Kit for Early Growth Response Protein 1 (EGR1)	CLIA assay for Antigen Detection
Assay Kits	ELW389Hu01	ELISA Kit for Early Growth Response Protein 1 (EGR1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW389Mu01	Recombinant Early Growth Response Protein 1 (EGR1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW389Mu01	Monoclonal Antibody to Early Growth Response Protein 1 (EGR1)	WB; IHC; ICC; IP.
Antibodies	PAW389Mu01	Polyclonal Antibody to Early Growth Response Protein 1 (EGR1)	WB; IHC; ICC; IF.
Assay Kits	CLW389Mu01	CLIA Kit for Early Growth Response Protein 1 (EGR1)	CLIA assay for Antigen Detection
Assay Kits	ELW389Mu01	ELISA Kit for Early Growth Response Protein 1 (EGR1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW389Ra01	Recombinant Early Growth Response Protein 1 (EGR1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW389Ra01	Monoclonal Antibody to Early Growth Response Protein 1 (EGR1)	WB; IHC; ICC; IP.
Antibodies	PAW389Ra01	Polyclonal Antibody to Early Growth Response Protein 1 (EGR1)	WB; IHC; ICC; IF.
Assay Kits	CLW389Ra01	CLIA Kit for Early Growth Response Protein 1 (EGR1)	CLIA assay for Antigen Detection
Assay Kits	ELW389Ra01	ELISA Kit for Early Growth Response Protein 1 (EGR1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW389Ca01	Recombinant Early Growth Response Protein 1 (EGR1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW389Ca01	Monoclonal Antibody to Early Growth Response Protein 1 (EGR1)	WB; IHC; ICC; IP.
Antibodies	PAW389Ca01	Polyclonal Antibody to Early Growth Response Protein 1 (EGR1)	WB; IHC; ICC; IF.
Assay Kits	CLW389Ca01	CLIA Kit for Early Growth Response Protein 1 (EGR1)	CLIA assay for Antigen Detection
Assay Kits	ELW389Ca01	ELISA Kit for Early Growth Response Protein 1 (EGR1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW389Po01	Recombinant Early Growth Response Protein 1 (EGR1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW389Po01	Monoclonal Antibody to Early Growth Response Protein 1 (EGR1)	WB; IHC; ICC; IP.
Antibodies	PAW389Po01	Polyclonal Antibody to Early Growth Response Protein 1 (EGR1)	WB; IHC; ICC; IF.
Assay Kits	CLW389Po01	CLIA Kit for Early Growth Response Protein 1 (EGR1)	CLIA assay for Antigen Detection
Assay Kits	ELW389Po01	ELISA Kit for Early Growth Response Protein 1 (EGR1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW389Bo01	Recombinant Early Growth Response Protein 1 (EGR1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW389Bo01	Monoclonal Antibody to Early Growth Response Protein 1 (EGR1)	WB; IHC; ICC; IP.
Antibodies	PAW389Bo01	Polyclonal Antibody to Early Growth Response Protein 1 (EGR1)	WB; IHC; ICC; IF.
Assay Kits	CLW389Bo01	CLIA Kit for Early Growth Response Protein 1 (EGR1)	CLIA assay for Antigen Detection
Assay Kits	ELW389Bo01	ELISA Kit for Early Growth Response Protein 1 (EGR1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW389Rb01	Recombinant Early Growth Response Protein 1 (EGR1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW389Rb01	Monoclonal Antibody to Early Growth Response Protein 1 (EGR1)	WB; IHC; ICC; IP.
Antibodies	PAW389Rb01	Polyclonal Antibody to Early Growth Response Protein 1 (EGR1)	WB; IHC; ICC; IF.
Assay Kits	CLW389Rb01	CLIA Kit for Early Growth Response Protein 1 (EGR1)	CLIA assay for Antigen Detection
Assay Kits	ELW389Rb01	ELISA Kit for Early Growth Response Protein 1 (EGR1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW389Mo01	Recombinant Early Growth Response Protein 1 (EGR1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW389Mo01	Monoclonal Antibody to Early Growth Response Protein 1 (EGR1)	WB; IHC; ICC; IP.
Antibodies	PAW389Mo01	Polyclonal Antibody to Early Growth Response Protein 1 (EGR1)	WB; IHC; ICC; IF.
Assay Kits	CLW389Mo01	CLIA Kit for Early Growth Response Protein 1 (EGR1)	CLIA assay for Antigen Detection
Assay Kits	ELW389Mo01	ELISA Kit for Early Growth Response Protein 1 (EGR1)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"cDNA sequence of the human cellular early growth response gene Egr-1."
Nucleic Acids Res. 18:4283-4283(1990) [PubMed] [Europe PMC] [Abstract]

"A gene coding for a zinc finger protein is induced during 12-O-tetradecanoylphorbol-13-acetate-stimulated HL-60 cell differentiation."
J. Biochem. 111:272-277(1992) [PubMed] [Europe PMC] [Abstract]

"Expression of a zinc finger gene in HTLV-I- and HTLV-II-transformed cells."
Science 248:588-591(1990) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b."
FEBS J. 277:1202-1218(2010) [PubMed] [Europe PMC] [Abstract]