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Octamer Binding Transcription Factor 4 (OCT4)

POU5F1; OCT3; OTF3; OTF4; Octamer-4; POU Domain Class 5 Transcription Factor 1; POU Class 5 Homoeobox 1; Octamer-binding protein 3

Oct-4 is a homeodomain transcription factor of the POU family. This protein is critically involved in the self-renewal of undifferentiated embryonic stem cells. As such, it is frequently used as a marker for undifferentiated cells. Oct-4 expression must be closely regulated; too much or too little will actually cause differentiation of the cells.

Oct-4 transcription factor is initially active as a maternal factor in the oocyte but remains active in embryos throughout the preimplantation period. Oct-4 expression is associated with an undifferentiated phenotype and tumors. In fact gene knockdown of Oct-4 promotes differentiation, thereby demonstrating a role for these factors in human embryonic stem cell self-renewal.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW381Hu01 Recombinant Octamer Binding Transcription Factor 4 (OCT4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW381Hu01 Monoclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IP.
PAW381Hu01 Polyclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IF.
Assay Kits CLW381Hu01 CLIA Kit for Octamer Binding Transcription Factor 4 (OCT4) CLIA assay for Antigen Detection
ELW381Hu01 ELISA Kit for Octamer Binding Transcription Factor 4 (OCT4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW381Mu01 Recombinant Octamer Binding Transcription Factor 4 (OCT4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW381Mu01 Monoclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IP.
PAW381Mu01 Polyclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IF.
Assay Kits CLW381Mu01 CLIA Kit for Octamer Binding Transcription Factor 4 (OCT4) CLIA assay for Antigen Detection
ELW381Mu01 ELISA Kit for Octamer Binding Transcription Factor 4 (OCT4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW381Ra01 Recombinant Octamer Binding Transcription Factor 4 (OCT4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW381Ra01 Monoclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IP.
PAW381Ra01 Polyclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IF.
Assay Kits CLW381Ra01 CLIA Kit for Octamer Binding Transcription Factor 4 (OCT4) CLIA assay for Antigen Detection
ELW381Ra01 ELISA Kit for Octamer Binding Transcription Factor 4 (OCT4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW381Ca01 Recombinant Octamer Binding Transcription Factor 4 (OCT4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW381Ca01 Monoclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IP.
PAW381Ca01 Polyclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IF.
Assay Kits CLW381Ca01 CLIA Kit for Octamer Binding Transcription Factor 4 (OCT4) CLIA assay for Antigen Detection
ELW381Ca01 ELISA Kit for Octamer Binding Transcription Factor 4 (OCT4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW381Po01 Recombinant Octamer Binding Transcription Factor 4 (OCT4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW381Po01 Monoclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IP.
PAW381Po01 Polyclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IF.
Assay Kits CLW381Po01 CLIA Kit for Octamer Binding Transcription Factor 4 (OCT4) CLIA assay for Antigen Detection
ELW381Po01 ELISA Kit for Octamer Binding Transcription Factor 4 (OCT4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW381Bo01 Recombinant Octamer Binding Transcription Factor 4 (OCT4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW381Bo01 Monoclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IP.
PAW381Bo01 Polyclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IF.
Assay Kits CLW381Bo01 CLIA Kit for Octamer Binding Transcription Factor 4 (OCT4) CLIA assay for Antigen Detection
ELW381Bo01 ELISA Kit for Octamer Binding Transcription Factor 4 (OCT4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW381Rb01 Recombinant Octamer Binding Transcription Factor 4 (OCT4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW381Rb01 Monoclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IP.
PAW381Rb01 Polyclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IF.
Assay Kits CLW381Rb01 CLIA Kit for Octamer Binding Transcription Factor 4 (OCT4) CLIA assay for Antigen Detection
ELW381Rb01 ELISA Kit for Octamer Binding Transcription Factor 4 (OCT4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW381Mo01 Recombinant Octamer Binding Transcription Factor 4 (OCT4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW381Mo01 Monoclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IP.
PAW381Mo01 Polyclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IF.
Assay Kits CLW381Mo01 CLIA Kit for Octamer Binding Transcription Factor 4 (OCT4) CLIA assay for Antigen Detection
ELW381Mo01 ELISA Kit for Octamer Binding Transcription Factor 4 (OCT4) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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"Expression of transcription regulating genes in human preimplantation embryos."
Hum. Reprod. 10:2787-2792(1995) [PubMed] [Europe PMC] [Abstract]

"Oct4 pseudogenes are transcribed in cancers."
Biochem. Biophys. Res. Commun. 337:1047-1051(2005) [PubMed] [Europe PMC] [Abstract]

"Induction of pluripotent stem cells from adult human fibroblasts by defined factors."
Cell 131:861-872(2007) [PubMed] [Europe PMC] [Abstract]

"Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription."
Int. J. Biochem. Cell Biol. 40:1043-1054(2008) [PubMed] [Europe PMC] [Abstract]

"WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells."
Cell Res. 19:561-573(2009) [PubMed] [Europe PMC] [Abstract]

"Serine 111 phosphorylation regulates OCT4A protein subcellular distribution and degradation."
J. Biol. Chem. 287:38279-38288(2012) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation regulates human OCT4."
Proc. Natl. Acad. Sci. U.S.A. 109:7162-7168(2012) [PubMed] [Europe PMC] [Abstract]