Apobec 1 Complementation Factor (ACF)
ASP; ACF64; ACF65; A1CF; APOBEC1CF; Apolipoprotein B MRNA Editing Enzyme Catalytic Polypeptide 1 Complementation Factor; APOBEC1-stimulating protein
Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Alternative splicing occurs at this locus and three full-length transcript variants, encoding three distinct isoforms, have been described.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW379Hu01 | Recombinant Apobec 1 Complementation Factor (ACF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW379Hu01 | Monoclonal Antibody to Apobec 1 Complementation Factor (ACF) | WB; IHC; ICC; IP. |
| PAW379Hu01 | Polyclonal Antibody to Apobec 1 Complementation Factor (ACF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW379Hu01 | CLIA Kit for Apobec 1 Complementation Factor (ACF) | CLIA assay for Antigen Detection |
| ELW379Hu01 | ELISA Kit for Apobec 1 Complementation Factor (ACF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW379Mu01 | Recombinant Apobec 1 Complementation Factor (ACF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW379Mu01 | Monoclonal Antibody to Apobec 1 Complementation Factor (ACF) | WB; IHC; ICC; IP. |
| PAW379Mu01 | Polyclonal Antibody to Apobec 1 Complementation Factor (ACF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW379Mu01 | CLIA Kit for Apobec 1 Complementation Factor (ACF) | CLIA assay for Antigen Detection |
| ELW379Mu01 | ELISA Kit for Apobec 1 Complementation Factor (ACF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW379Ra01 | Recombinant Apobec 1 Complementation Factor (ACF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW379Ra01 | Monoclonal Antibody to Apobec 1 Complementation Factor (ACF) | WB; IHC; ICC; IP. |
| PAW379Ra01 | Polyclonal Antibody to Apobec 1 Complementation Factor (ACF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW379Ra01 | CLIA Kit for Apobec 1 Complementation Factor (ACF) | CLIA assay for Antigen Detection |
| ELW379Ra01 | ELISA Kit for Apobec 1 Complementation Factor (ACF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW379Ca01 | Recombinant Apobec 1 Complementation Factor (ACF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW379Ca01 | Monoclonal Antibody to Apobec 1 Complementation Factor (ACF) | WB; IHC; ICC; IP. |
| PAW379Ca01 | Polyclonal Antibody to Apobec 1 Complementation Factor (ACF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW379Ca01 | CLIA Kit for Apobec 1 Complementation Factor (ACF) | CLIA assay for Antigen Detection |
| ELW379Ca01 | ELISA Kit for Apobec 1 Complementation Factor (ACF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW379Po01 | Recombinant Apobec 1 Complementation Factor (ACF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW379Po01 | Monoclonal Antibody to Apobec 1 Complementation Factor (ACF) | WB; IHC; ICC; IP. |
| PAW379Po01 | Polyclonal Antibody to Apobec 1 Complementation Factor (ACF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW379Po01 | CLIA Kit for Apobec 1 Complementation Factor (ACF) | CLIA assay for Antigen Detection |
| ELW379Po01 | ELISA Kit for Apobec 1 Complementation Factor (ACF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW379Bo01 | Recombinant Apobec 1 Complementation Factor (ACF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW379Bo01 | Monoclonal Antibody to Apobec 1 Complementation Factor (ACF) | WB; IHC; ICC; IP. |
| PAW379Bo01 | Polyclonal Antibody to Apobec 1 Complementation Factor (ACF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW379Bo01 | CLIA Kit for Apobec 1 Complementation Factor (ACF) | CLIA assay for Antigen Detection |
| ELW379Bo01 | ELISA Kit for Apobec 1 Complementation Factor (ACF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW379Rb01 | Recombinant Apobec 1 Complementation Factor (ACF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW379Rb01 | Monoclonal Antibody to Apobec 1 Complementation Factor (ACF) | WB; IHC; ICC; IP. |
| PAW379Rb01 | Polyclonal Antibody to Apobec 1 Complementation Factor (ACF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW379Rb01 | CLIA Kit for Apobec 1 Complementation Factor (ACF) | CLIA assay for Antigen Detection |
| ELW379Rb01 | ELISA Kit for Apobec 1 Complementation Factor (ACF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW379Mo01 | Recombinant Apobec 1 Complementation Factor (ACF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW379Mo01 | Monoclonal Antibody to Apobec 1 Complementation Factor (ACF) | WB; IHC; ICC; IP. |
| PAW379Mo01 | Polyclonal Antibody to Apobec 1 Complementation Factor (ACF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW379Mo01 | CLIA Kit for Apobec 1 Complementation Factor (ACF) | CLIA assay for Antigen Detection |
| ELW379Mo01 | ELISA Kit for Apobec 1 Complementation Factor (ACF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex."
J. Biol. Chem. 275:19848-19856(2000) [PubMed] [Europe PMC] [Abstract] and Small intestine.
"Molecular cloning of APOBEC-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA."
Mol. Cell. Biol. 20:1846-1854(2000) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing."
J. Biol. Chem. 276:10272-10283(2001) [PubMed] [Europe PMC] [Abstract]
"Isolation, characterization and developmental regulation of the human apobec-1 complementation factor (ACF) gene."
Biochim. Biophys. Acta 1522:22-30(2001) [PubMed] [Europe PMC] [Abstract]
"Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing."
RNA 8:69-82(2002) [PubMed] [Europe PMC] [Abstract]
"The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay."
EMBO J. 22:3971-3982(2003) [PubMed] [Europe PMC] [Abstract]
"A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling."
J. Biol. Chem. 278:41198-41204(2003) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Solution structure of the RNA recognition motif of human APOBEC-1 complementation factor, ACF."
Submitted (NOV-2005) to the PDB data bank