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Trophoblast Glycoprotein (TPBG)

5T4-AG; M6P1; WAIF1; 5T4 oncofetal trophoblast glycoprotein; Wnt-activated inhibitory factor 1

5T4 is an antigen expressed in a number of carcinomas. It is an N-glycosylated transmembrane 72 kDa glycoprotein containing seven leucine-rich repeat regions. 5T4 is often referred to as an oncofetal antigen due to its expression in foetal trophoblast (where it was first discovered) or trophoblast glycoprotein (TPBG).

5T4 is found in tumors including the colorectal, ovarian, and gastric. Its expression is used as a prognostic aid in these cases. It has very limited expression in normal tissue but is widespread in malignant tumors throughout their development. Its confined expression appears to give 5T4 the potential to be useful in cancer immunotherapy. 5T4 is also the target of the cancer vaccine TroVax which is used in the treatment of colorectal cancer.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW372Hu01 Recombinant Trophoblast Glycoprotein (TPBG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW372Hu01 Monoclonal Antibody to Trophoblast Glycoprotein (TPBG) WB; IHC; ICC; IP.
PAW372Hu01 Polyclonal Antibody to Trophoblast Glycoprotein (TPBG) WB; IHC; ICC; IF.
Assay Kits CLW372Hu01 CLIA Kit for Trophoblast Glycoprotein (TPBG) CLIA assay for Antigen Detection
ELW372Hu01 ELISA Kit for Trophoblast Glycoprotein (TPBG) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW372Mu01 Recombinant Trophoblast Glycoprotein (TPBG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW372Mu01 Monoclonal Antibody to Trophoblast Glycoprotein (TPBG) WB; IHC; ICC; IP.
PAW372Mu01 Polyclonal Antibody to Trophoblast Glycoprotein (TPBG) WB; IHC; ICC; IF.
Assay Kits CLW372Mu01 CLIA Kit for Trophoblast Glycoprotein (TPBG) CLIA assay for Antigen Detection
ELW372Mu01 ELISA Kit for Trophoblast Glycoprotein (TPBG) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW372Ra01 Recombinant Trophoblast Glycoprotein (TPBG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW372Ra01 Monoclonal Antibody to Trophoblast Glycoprotein (TPBG) WB; IHC; ICC; IP.
PAW372Ra01 Polyclonal Antibody to Trophoblast Glycoprotein (TPBG) WB; IHC; ICC; IF.
Assay Kits CLW372Ra01 CLIA Kit for Trophoblast Glycoprotein (TPBG) CLIA assay for Antigen Detection
ELW372Ra01 ELISA Kit for Trophoblast Glycoprotein (TPBG) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW372Ca01 Recombinant Trophoblast Glycoprotein (TPBG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW372Ca01 Monoclonal Antibody to Trophoblast Glycoprotein (TPBG) WB; IHC; ICC; IP.
PAW372Ca01 Polyclonal Antibody to Trophoblast Glycoprotein (TPBG) WB; IHC; ICC; IF.
Assay Kits CLW372Ca01 CLIA Kit for Trophoblast Glycoprotein (TPBG) CLIA assay for Antigen Detection
ELW372Ca01 ELISA Kit for Trophoblast Glycoprotein (TPBG) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW372Po01 Recombinant Trophoblast Glycoprotein (TPBG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW372Po01 Monoclonal Antibody to Trophoblast Glycoprotein (TPBG) WB; IHC; ICC; IP.
PAW372Po01 Polyclonal Antibody to Trophoblast Glycoprotein (TPBG) WB; IHC; ICC; IF.
Assay Kits CLW372Po01 CLIA Kit for Trophoblast Glycoprotein (TPBG) CLIA assay for Antigen Detection
ELW372Po01 ELISA Kit for Trophoblast Glycoprotein (TPBG) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW372Bo01 Recombinant Trophoblast Glycoprotein (TPBG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW372Bo01 Monoclonal Antibody to Trophoblast Glycoprotein (TPBG) WB; IHC; ICC; IP.
PAW372Bo01 Polyclonal Antibody to Trophoblast Glycoprotein (TPBG) WB; IHC; ICC; IF.
Assay Kits CLW372Bo01 CLIA Kit for Trophoblast Glycoprotein (TPBG) CLIA assay for Antigen Detection
ELW372Bo01 ELISA Kit for Trophoblast Glycoprotein (TPBG) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW372Rb01 Recombinant Trophoblast Glycoprotein (TPBG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW372Rb01 Monoclonal Antibody to Trophoblast Glycoprotein (TPBG) WB; IHC; ICC; IP.
PAW372Rb01 Polyclonal Antibody to Trophoblast Glycoprotein (TPBG) WB; IHC; ICC; IF.
Assay Kits CLW372Rb01 CLIA Kit for Trophoblast Glycoprotein (TPBG) CLIA assay for Antigen Detection
ELW372Rb01 ELISA Kit for Trophoblast Glycoprotein (TPBG) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW372Mo01 Recombinant Trophoblast Glycoprotein (TPBG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW372Mo01 Monoclonal Antibody to Trophoblast Glycoprotein (TPBG) WB; IHC; ICC; IP.
PAW372Mo01 Polyclonal Antibody to Trophoblast Glycoprotein (TPBG) WB; IHC; ICC; IF.
Assay Kits CLW372Mo01 CLIA Kit for Trophoblast Glycoprotein (TPBG) CLIA assay for Antigen Detection
ELW372Mo01 ELISA Kit for Trophoblast Glycoprotein (TPBG) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Isolation of a cDNA encoding 5T4 oncofetal trophoblast glycoprotein: an antigen associated with metastasis contains leucine rich repeats."
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"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
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Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Attenuated recombinant vaccinia virus expressing oncofetal antigen (tumor-associated antigen) 5T4 induces active therapy of established tumors."
Mol. Cancer Ther. 1:1129-1137(2002) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Waif1/5T4 inhibits Wnt/beta-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization."
Dev. Cell 21:1129-1143(2011) [PubMed] [Europe PMC] [Abstract]

"Structural insights into the inhibition of Wnt signaling by cancer antigen 5T4/Wnt-activated inhibitory factor 1."
Structure 22:612-620(2014) [PubMed] [Europe PMC] [Abstract]