Endothelin Converting Enzyme 1 (ECE1)

SPN	W323
HGNC	3146
MGI	1101357
PubMed	8359888
RGD	620293
UniProt	P42892
Wiki	ECE1

Endothelin converting enzyme 1, also known as ECE1, is a enzyme which in humans is encoded by the ECE1 gene.Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1), -2 (EDN2), and -3 (EDN3) to biologically active peptides.

Schmidt et al. (1994) purified a membrane-bound protease activity from bovine endothelial cells that specifically converts the inactive form to EDN1. The enzyme was cleaved with trypsin and peptide sequencing analysis confirmed it to be a zinc-chelating metalloprotease containing the typical HEXXH (HELTH) motif. RT-PCR and cDNA screens were used to isolate the complete cDNAs of the bovine and human enzymes.

Reference

"Cloning and sequencing of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2."
Biochem. Biophys. Res. Commun. 208:721-727(1995) [PubMed] [Europe PMC] [Abstract]

"Cloning and functional expression of human endothelin-converting enzyme cDNA."
Biochem. Biophys. Res. Commun. 207:807-812(1995) [PubMed] [Europe PMC] [Abstract]

"Organization of the gene encoding the human endothelin-converting enzyme (ECE-1)."
J. Biol. Chem. 270:29794-29798(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A fourth isoform of endothelin-converting enzyme (ECE-1) is generated from an additional promoter."
Eur. J. Biochem. 264:341-349(1999) [PubMed] [Europe PMC] [Abstract]

"Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations."
Biochem. J. 328:871-877(1997) [PubMed] [Europe PMC] [Abstract]

"Molecular characterization of human and bovine endothelin converting enzyme (ECE-1)."
FEBS Lett. 356:238-243(1994) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Structure of human endothelin-converting enzyme I complexed with phosphoramidon."
J. Mol. Biol. 385:178-187(2009) [PubMed] [Europe PMC] [Abstract]

"A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction."
Am. J. Hum. Genet. 64:304-308(1999) [PubMed] [Europe PMC] [Abstract]