Keratin 4 (KRT4)
CYK4; CK4; K4; Cytokeratin 4; Keratin, type II cytoskeletal 4; Type-II keratin Kb4
Keratin 4 isa member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13.
Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq]. Sequence Note: The RefSeq represents one of two co-dominant alleles identified for this gene.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW318Hu01 | Recombinant Keratin 4 (KRT4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW318Hu01 | Monoclonal Antibody to Keratin 4 (KRT4) | WB; IHC; ICC; IP. |
| PAW318Hu01 | Polyclonal Antibody to Keratin 4 (KRT4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW318Hu01 | CLIA Kit for Keratin 4 (KRT4) | CLIA assay for Antigen Detection |
| ELW318Hu01 | ELISA Kit for Keratin 4 (KRT4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW318Mu01 | Recombinant Keratin 4 (KRT4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW318Mu01 | Monoclonal Antibody to Keratin 4 (KRT4) | WB; IHC; ICC; IP. |
| PAW318Mu01 | Polyclonal Antibody to Keratin 4 (KRT4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW318Mu01 | CLIA Kit for Keratin 4 (KRT4) | CLIA assay for Antigen Detection |
| ELW318Mu01 | ELISA Kit for Keratin 4 (KRT4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW318Ra01 | Recombinant Keratin 4 (KRT4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW318Ra01 | Monoclonal Antibody to Keratin 4 (KRT4) | WB; IHC; ICC; IP. |
| PAW318Ra01 | Polyclonal Antibody to Keratin 4 (KRT4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW318Ra01 | CLIA Kit for Keratin 4 (KRT4) | CLIA assay for Antigen Detection |
| ELW318Ra01 | ELISA Kit for Keratin 4 (KRT4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW318Ca01 | Recombinant Keratin 4 (KRT4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW318Ca01 | Monoclonal Antibody to Keratin 4 (KRT4) | WB; IHC; ICC; IP. |
| PAW318Ca01 | Polyclonal Antibody to Keratin 4 (KRT4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW318Ca01 | CLIA Kit for Keratin 4 (KRT4) | CLIA assay for Antigen Detection |
| ELW318Ca01 | ELISA Kit for Keratin 4 (KRT4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW318Po01 | Recombinant Keratin 4 (KRT4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW318Po01 | Monoclonal Antibody to Keratin 4 (KRT4) | WB; IHC; ICC; IP. |
| PAW318Po01 | Polyclonal Antibody to Keratin 4 (KRT4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW318Po01 | CLIA Kit for Keratin 4 (KRT4) | CLIA assay for Antigen Detection |
| ELW318Po01 | ELISA Kit for Keratin 4 (KRT4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW318Bo01 | Recombinant Keratin 4 (KRT4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW318Bo01 | Monoclonal Antibody to Keratin 4 (KRT4) | WB; IHC; ICC; IP. |
| PAW318Bo01 | Polyclonal Antibody to Keratin 4 (KRT4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW318Bo01 | CLIA Kit for Keratin 4 (KRT4) | CLIA assay for Antigen Detection |
| ELW318Bo01 | ELISA Kit for Keratin 4 (KRT4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW318Rb01 | Recombinant Keratin 4 (KRT4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW318Rb01 | Monoclonal Antibody to Keratin 4 (KRT4) | WB; IHC; ICC; IP. |
| PAW318Rb01 | Polyclonal Antibody to Keratin 4 (KRT4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW318Rb01 | CLIA Kit for Keratin 4 (KRT4) | CLIA assay for Antigen Detection |
| ELW318Rb01 | ELISA Kit for Keratin 4 (KRT4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW318Mo01 | Recombinant Keratin 4 (KRT4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW318Mo01 | Monoclonal Antibody to Keratin 4 (KRT4) | WB; IHC; ICC; IP. |
| PAW318Mo01 | Polyclonal Antibody to Keratin 4 (KRT4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW318Mo01 | CLIA Kit for Keratin 4 (KRT4) | CLIA assay for Antigen Detection |
| ELW318Mo01 | ELISA Kit for Keratin 4 (KRT4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Allelic variations of human keratins K4 and K5 provide polymorphic markers within the type II keratin gene cluster on chromosome 12."
J. Invest. Dermatol. 100:735-741(1993) [PubMed] [Europe PMC] [Abstract]
"Molecular characterization and expression of the stratification-related cytokeratins 4 and 15."
J. Cell Biol. 106:1249-1261(1988) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"A glutamine insertion in the 1A alpha helical domain of the keratin 4 gene in a familial case of white sponge nevus."
J. Invest. Dermatol. 114:388-391(2000) [PubMed] [Europe PMC] [Abstract]
"A novel mutation in the keratin 4 gene causing white sponge naevus."
Br. J. Dermatol. 148:1125-1128(2003) [PubMed] [Europe PMC] [Abstract]