Keratin 16 (KRT16)
CK16; NEPPK; Cytokeratin 16; Focal Non-Epidermolytic Palmoplantar Keratoderma; Keratin, type I cytoskeletal 16
Keratin 16 is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21.
This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW293Hu01 | Recombinant Keratin 16 (KRT16) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW293Hu01 | Monoclonal Antibody to Keratin 16 (KRT16) | WB; IHC; ICC; IP. |
| PAW293Hu01 | Polyclonal Antibody to Keratin 16 (KRT16) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW293Hu01 | CLIA Kit for Keratin 16 (KRT16) | CLIA assay for Antigen Detection |
| ELW293Hu01 | ELISA Kit for Keratin 16 (KRT16) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW293Mu01 | Recombinant Keratin 16 (KRT16) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW293Mu01 | Monoclonal Antibody to Keratin 16 (KRT16) | WB; IHC; ICC; IP. |
| PAW293Mu01 | Polyclonal Antibody to Keratin 16 (KRT16) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW293Mu01 | CLIA Kit for Keratin 16 (KRT16) | CLIA assay for Antigen Detection |
| ELW293Mu01 | ELISA Kit for Keratin 16 (KRT16) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW293Ra01 | Recombinant Keratin 16 (KRT16) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW293Ra01 | Monoclonal Antibody to Keratin 16 (KRT16) | WB; IHC; ICC; IP. |
| PAW293Ra01 | Polyclonal Antibody to Keratin 16 (KRT16) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW293Ra01 | CLIA Kit for Keratin 16 (KRT16) | CLIA assay for Antigen Detection |
| ELW293Ra01 | ELISA Kit for Keratin 16 (KRT16) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW293Ca01 | Recombinant Keratin 16 (KRT16) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW293Ca01 | Monoclonal Antibody to Keratin 16 (KRT16) | WB; IHC; ICC; IP. |
| PAW293Ca01 | Polyclonal Antibody to Keratin 16 (KRT16) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW293Ca01 | CLIA Kit for Keratin 16 (KRT16) | CLIA assay for Antigen Detection |
| ELW293Ca01 | ELISA Kit for Keratin 16 (KRT16) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW293Po01 | Recombinant Keratin 16 (KRT16) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW293Po01 | Monoclonal Antibody to Keratin 16 (KRT16) | WB; IHC; ICC; IP. |
| PAW293Po01 | Polyclonal Antibody to Keratin 16 (KRT16) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW293Po01 | CLIA Kit for Keratin 16 (KRT16) | CLIA assay for Antigen Detection |
| ELW293Po01 | ELISA Kit for Keratin 16 (KRT16) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW293Bo01 | Recombinant Keratin 16 (KRT16) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW293Bo01 | Monoclonal Antibody to Keratin 16 (KRT16) | WB; IHC; ICC; IP. |
| PAW293Bo01 | Polyclonal Antibody to Keratin 16 (KRT16) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW293Bo01 | CLIA Kit for Keratin 16 (KRT16) | CLIA assay for Antigen Detection |
| ELW293Bo01 | ELISA Kit for Keratin 16 (KRT16) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW293Rb01 | Recombinant Keratin 16 (KRT16) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW293Rb01 | Monoclonal Antibody to Keratin 16 (KRT16) | WB; IHC; ICC; IP. |
| PAW293Rb01 | Polyclonal Antibody to Keratin 16 (KRT16) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW293Rb01 | CLIA Kit for Keratin 16 (KRT16) | CLIA assay for Antigen Detection |
| ELW293Rb01 | ELISA Kit for Keratin 16 (KRT16) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW293Mo01 | Recombinant Keratin 16 (KRT16) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW293Mo01 | Monoclonal Antibody to Keratin 16 (KRT16) | WB; IHC; ICC; IP. |
| PAW293Mo01 | Polyclonal Antibody to Keratin 16 (KRT16) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW293Mo01 | CLIA Kit for Keratin 16 (KRT16) | CLIA assay for Antigen Detection |
| ELW293Mo01 | ELISA Kit for Keratin 16 (KRT16) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Three tightly linked genes encoding human type I keratins: conservation of sequence in the 5'-untranslated leader and 5'-upstream regions of coexpressed keratin genes."
Mol. Cell. Biol. 6:539-548(1986) [PubMed] [Europe PMC] [Abstract]
"A group of type I keratin genes on human chromosome 17: characterization and expression."
Mol. Cell. Biol. 8:722-736(1988) [PubMed] [Europe PMC] [Abstract]
"cDNA cloning and bacterial expression of the human type I keratin 16."
Biochem. Biophys. Res. Commun. 215:517-523(1995) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Keratin 16 and keratin 17 mutations cause pachyonychia congenita."
Nat. Genet. 9:273-278(1995) [PubMed] [Europe PMC] [Abstract]
"Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
"Cluster analysis of an extensive human breast cancer cell line protein expression map database."
Proteomics 2:212-223(2002) [PubMed] [Europe PMC] [Abstract]
"Identification of trichoplein, a novel keratin filament-binding protein."
J. Cell Sci. 118:1081-1090(2005) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Novel mutations in keratin 16 gene underly focal nonepidermolytic palmoplantar keratoderma (NEPPK) in two families."
Hum. Mol. Genet. 4:1875-1881(1995) [PubMed] [Europe PMC] [Abstract]
"Novel proline substitution mutations in keratin 16 in two cases of pachyonychia congenita type 1."
Br. J. Dermatol. 141:1010-1016(1999) [PubMed] [Europe PMC] [Abstract]
"Cloning of multiple keratin 16 genes facilitates prenatal diagnosis of pachyonychia congenita type 1."
Prenat. Diagn. 19:941-946(1999) [PubMed] [Europe PMC] [Abstract]
"Novel keratin 16 mutations and protein expression studies in pachyonychia congenita type 1 and focal palmoplantar keratoderma."
Exp. Dermatol. 9:170-177(2000) [PubMed] [Europe PMC] [Abstract]
"A mutation in the V1 domain of K16 is responsible for unilateral palmoplantar verrucous nevus."
J. Invest. Dermatol. 114:1136-1140(2000) [PubMed] [Europe PMC] [Abstract]
"Delayed-onset pachyonychia congenita associated with a novel mutation in the central 2B domain of keratin 16."
Br. J. Dermatol. 144:1058-1062(2001) [PubMed] [Europe PMC] [Abstract]
"Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita."
J. Invest. Dermatol. 117:1391-1396(2001) [PubMed] [Europe PMC] [Abstract]
"The genetic basis of pachyonychia congenita."
J. Investig. Dermatol. Symp. Proc. 10:21-30(2005) [PubMed] [Europe PMC] [Abstract]
"A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita."
J. Dermatol. Sci. 48:199-205(2007) [PubMed] [Europe PMC] [Abstract]
"A large mutational study in pachyonychia congenita."
J. Invest. Dermatol. 131:1018-1024(2011) [PubMed] [Europe PMC] [Abstract]
"Genotype-phenotype correlations among pachyonychia congenita patients with K16 mutations."
J. Invest. Dermatol. 131:1025-1028(2011) [PubMed] [Europe PMC] [Abstract]
"Two novel de novo mutations of KRT6A and KRT16 genes in two Chinese pachyonychia congenita pedigrees with fissured tongue or diffuse plantar keratoderma."
Eur. J. Dermatol. 22:476-480(2012) [PubMed] [Europe PMC] [Abstract]
"A new KRT16 mutation associated with a phenotype of pachyonychia congenita."
Exp. Dermatol. 22:838-839(2013) [PubMed] [Europe PMC] [Abstract]