Plasminogen Activator Inhibitor 2 (PAI2)
SERPINB2; PLANH2; Serpin Peptidase Inhibitor Clade B Member 2; Monocyte Arg-serpin; Placental plasminogen activator inhibitor; Serpin B2; Urokinase inhibitor
Plasminogen activator inhibitor-2 (placental PAI) is a coagulation factor that inactivates tPA and urokinase. It is present in most cells, especially monocytes/macrophages. PAI-2 exists in two forms, a 60-kDa extracellular glycosylated form and a 43-kDa intracellular form.
It is present only at detectable quantities in blood during pregnancy, as it is produced by the placenta, and may explain partially the increased rate of thrombosis during pregnancy. The majority of expressed PAI-2 remains unsecreted due to the presence of an inefficient internal signal peptide.the intron-exon arrangement of PAI2 is identical to that of chicken ovalbumin and Y genes and distinct from that of other members of the serpin superfamily.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW279Hu01 | Recombinant Plasminogen Activator Inhibitor 2 (PAI2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW279Hu01 | Monoclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) | WB; IHC; ICC; IP. |
| PAW279Hu01 | Polyclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW279Hu01 | CLIA Kit for Plasminogen Activator Inhibitor 2 (PAI2) | CLIA assay for Antigen Detection |
| ELW279Hu01 | ELISA Kit for Plasminogen Activator Inhibitor 2 (PAI2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW279Mu01 | Recombinant Plasminogen Activator Inhibitor 2 (PAI2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW279Mu01 | Monoclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) | WB; IHC; ICC; IP. |
| PAW279Mu01 | Polyclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW279Mu01 | CLIA Kit for Plasminogen Activator Inhibitor 2 (PAI2) | CLIA assay for Antigen Detection |
| ELW279Mu01 | ELISA Kit for Plasminogen Activator Inhibitor 2 (PAI2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW279Ra01 | Recombinant Plasminogen Activator Inhibitor 2 (PAI2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW279Ra01 | Monoclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) | WB; IHC; ICC; IP. |
| PAW279Ra01 | Polyclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW279Ra01 | CLIA Kit for Plasminogen Activator Inhibitor 2 (PAI2) | CLIA assay for Antigen Detection |
| ELW279Ra01 | ELISA Kit for Plasminogen Activator Inhibitor 2 (PAI2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW279Ca01 | Recombinant Plasminogen Activator Inhibitor 2 (PAI2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW279Ca01 | Monoclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) | WB; IHC; ICC; IP. |
| PAW279Ca01 | Polyclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW279Ca01 | CLIA Kit for Plasminogen Activator Inhibitor 2 (PAI2) | CLIA assay for Antigen Detection |
| ELW279Ca01 | ELISA Kit for Plasminogen Activator Inhibitor 2 (PAI2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW279Po01 | Recombinant Plasminogen Activator Inhibitor 2 (PAI2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW279Po01 | Monoclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) | WB; IHC; ICC; IP. |
| PAW279Po01 | Polyclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW279Po01 | CLIA Kit for Plasminogen Activator Inhibitor 2 (PAI2) | CLIA assay for Antigen Detection |
| ELW279Po01 | ELISA Kit for Plasminogen Activator Inhibitor 2 (PAI2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW279Bo01 | Recombinant Plasminogen Activator Inhibitor 2 (PAI2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW279Bo01 | Monoclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) | WB; IHC; ICC; IP. |
| PAW279Bo01 | Polyclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW279Bo01 | CLIA Kit for Plasminogen Activator Inhibitor 2 (PAI2) | CLIA assay for Antigen Detection |
| ELW279Bo01 | ELISA Kit for Plasminogen Activator Inhibitor 2 (PAI2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW279Rb01 | Recombinant Plasminogen Activator Inhibitor 2 (PAI2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW279Rb01 | Monoclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) | WB; IHC; ICC; IP. |
| PAW279Rb01 | Polyclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW279Rb01 | CLIA Kit for Plasminogen Activator Inhibitor 2 (PAI2) | CLIA assay for Antigen Detection |
| ELW279Rb01 | ELISA Kit for Plasminogen Activator Inhibitor 2 (PAI2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW279Mo01 | Recombinant Plasminogen Activator Inhibitor 2 (PAI2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW279Mo01 | Monoclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) | WB; IHC; ICC; IP. |
| PAW279Mo01 | Polyclonal Antibody to Plasminogen Activator Inhibitor 2 (PAI2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW279Mo01 | CLIA Kit for Plasminogen Activator Inhibitor 2 (PAI2) | CLIA assay for Antigen Detection |
| ELW279Mo01 | ELISA Kit for Plasminogen Activator Inhibitor 2 (PAI2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"cDNA cloning and expression in Escherichia coli of a plasminogen activator inhibitor from human placenta."
J. Biol. Chem. 262:3718-3725(1987) [PubMed] [Europe PMC] [Abstract]
"Plasminogen activator inhibitor 2: regulation of gene transcription during phorbol ester-mediated differentiation of U-937 human histiocytic lymphoma cells."
Mol. Cell. Biol. 7:4564-4567(1987) [PubMed] [Europe PMC] [Abstract]
"Human monocyte Arg-Serpin cDNA. Sequence, chromosomal assignment, and homology to plasminogen activator-inhibitor."
J. Exp. Med. 166:77-94(1987) [PubMed] [Europe PMC] [Abstract]
"Cloning and expression of a cDNA coding for a human monocyte-derived plasminogen activator inhibitor."
Proc. Natl. Acad. Sci. U.S.A. 85:985-989(1988) [PubMed] [Europe PMC] [Abstract]
"Structure of the gene for human plasminogen activator inhibitor-2. The nearest mammalian homologue of chicken ovalbumin."
J. Biol. Chem. 264:5495-5502(1989) [PubMed] [Europe PMC] [Abstract]
"Chromosomal organization and localization of the human urokinase inhibitor gene: perfect structural conservation with ovalbumin."
Genomics 6:159-167(1990) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
"Interaction of plasminogen activator inhibitor-2 and proteasome subunit, beta type 1."
Acta Biochim. Biophys. Sin. 36:42-46(2004) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"The crystal structure of plasminogen activator inhibitor 2 at 2.0-A resolution: implications for serpin function."
Structure 7:43-54(1999) [PubMed] [Europe PMC] [Abstract]
"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
Erratum
Nat. Genet. 23:373-373(1999)