Brain Natriuretic Peptide (BNP)
GC-B; B-Type Natriuretic Peptide; Ventricular Natriuretic Peptide; Gamma-brain natriuretic peptide; Brain natriuretic peptide 32
Brain natriuretic peptide is 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes). BNP is named as such because it was originally identified in extracts of porcine brain, although in humans it is produced mainly in the cardiac ventricles.
BNP is co-secreted along with a 76 amino acid N-terminal fragment (NT-proBNP) which is biologically inactive. BNP binds to and activates the atrial natriuretic factor receptors NPRA, and to a lesser extent NPRB, in a fashion similar to atrial natriuretic peptide (ANP) but with 10-fold lower affinity. The biological half-life of BNP, however, is twice as long as that of ANP, and that of NT-proBNP is even longer, making these peptides better targets than ANP for diagnostic blood testing.
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | N/A | Recombinant Brain Natriuretic Peptide (BNP) | Antigenic Transformation Customized Service Offer |
| Antibodies | N/A | Monoclonal Antibody to Brain Natriuretic Peptide (BNP) | Monoclonal Antibody Customized Service Offer |
| N/A | Polyclonal Antibody to Brain Natriuretic Peptide (BNP) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | N/A | CLIA Kit for Brain Natriuretic Peptide (BNP) | CLIA Kit Customized Service Offer |
| N/A | ELISA Kit for Brain Natriuretic Peptide (BNP) | ELISA Kit Customized Service Offer |
Reference
"Human and canine gene homologs of porcine brain natriuretic peptide."
Biochem. Biophys. Res. Commun. 165:650-658(1989) [PubMed] [Europe PMC] [Abstract]
"Cloning and sequence analysis of cDNA encoding a precursor for human brain natriuretic peptide."
Biochem. Biophys. Res. Commun. 159:1427-1434(1989) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Isolation and identification of human brain natriuretic peptides in cardiac atrium."
Biochem. Biophys. Res. Commun. 167:693-700(1990) [PubMed] [Europe PMC] [Abstract]
"Isolation and sequence determination of human brain natriuretic peptide in human atrium."
FEBS Lett. 259:341-345(1990) [PubMed] [Europe PMC] [Abstract]
"Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)."
Science 252:120-123(1991) [PubMed] [Europe PMC] [Abstract]
"The precursor to B-type natriuretic peptide is an O-linked glycoprotein."
Arch. Biochem. Biophys. 451:160-166(2006) [PubMed] [Europe PMC] [Abstract]
"Detection of endogenous B-type natriuretic peptide at very low concentrations in patients with heart failure."
Circ. Heart Fail. 1:258-264(2008) [PubMed] [Europe PMC] [Abstract]
"Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha."
FEBS J. 278:1316-1332(2011) [PubMed] [Europe PMC] [Abstract]
"Structural determinants of natriuretic peptide receptor specificity and degeneracy."
J. Mol. Biol. 361:698-714(2006) [PubMed] [Europe PMC] [Abstract]