Call Now

Immunoglobulin M (IgM)

IGHM; Immunoglobulin Heavy Constant Mu; Ig mu chain C region

  • Immunoglobulin M, or IgM for short, is a basic antibody that is present on B cells. It is the primary antibody against A and B antigens on red blood cells. IgM is by far the physically largest antibody in the human circulatory system. It is produced after an animal has been exposed to an antigen for an extended time or when an animal is exposed to an antigen for the second time. IgM forms polymers where multiple immunoglobulins are covalently linked together with disulfide bonds, mostly as a pentamer but also as a hexamer. IgM has a molecular mass of approximately 900 kD (in its pentamer form). Because each monomer has two antigen binding sites, a pentameric IgM has 10 binding sites. Typically, however, IgM cannot bind 10 antigens at the same time because the large size of most antigens hinders binding to nearby sites.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW267Hu01 Recombinant Immunoglobulin M (IgM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW267Hu01 Monoclonal Antibody to Immunoglobulin M (IgM) WB; IHC; ICC; IP.
PAW267Hu01 Polyclonal Antibody to Immunoglobulin M (IgM) WB; IHC; ICC; IF.
Assay Kits CLW267Hu01 CLIA Kit for Immunoglobulin M (IgM) CLIA assay for Antigen Detection
ELW267Hu01 ELISA Kit for Immunoglobulin M (IgM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW267Mu01 Recombinant Immunoglobulin M (IgM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW267Mu01 Monoclonal Antibody to Immunoglobulin M (IgM) WB; IHC; ICC; IP.
PAW267Mu01 Polyclonal Antibody to Immunoglobulin M (IgM) WB; IHC; ICC; IF.
Assay Kits CLW267Mu01 CLIA Kit for Immunoglobulin M (IgM) CLIA assay for Antigen Detection
ELW267Mu01 ELISA Kit for Immunoglobulin M (IgM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW267Ra01 Recombinant Immunoglobulin M (IgM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW267Ra01 Monoclonal Antibody to Immunoglobulin M (IgM) WB; IHC; ICC; IP.
PAW267Ra01 Polyclonal Antibody to Immunoglobulin M (IgM) WB; IHC; ICC; IF.
Assay Kits CLW267Ra01 CLIA Kit for Immunoglobulin M (IgM) CLIA assay for Antigen Detection
ELW267Ra01 ELISA Kit for Immunoglobulin M (IgM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW267Ca01 Recombinant Immunoglobulin M (IgM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW267Ca01 Monoclonal Antibody to Immunoglobulin M (IgM) WB; IHC; ICC; IP.
PAW267Ca01 Polyclonal Antibody to Immunoglobulin M (IgM) WB; IHC; ICC; IF.
Assay Kits CLW267Ca01 CLIA Kit for Immunoglobulin M (IgM) CLIA assay for Antigen Detection
ELW267Ca01 ELISA Kit for Immunoglobulin M (IgM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW267Po01 Recombinant Immunoglobulin M (IgM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW267Po01 Monoclonal Antibody to Immunoglobulin M (IgM) WB; IHC; ICC; IP.
PAW267Po01 Polyclonal Antibody to Immunoglobulin M (IgM) WB; IHC; ICC; IF.
Assay Kits CLW267Po01 CLIA Kit for Immunoglobulin M (IgM) CLIA assay for Antigen Detection
ELW267Po01 ELISA Kit for Immunoglobulin M (IgM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW267Bo01 Recombinant Immunoglobulin M (IgM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW267Bo01 Monoclonal Antibody to Immunoglobulin M (IgM) WB; IHC; ICC; IP.
PAW267Bo01 Polyclonal Antibody to Immunoglobulin M (IgM) WB; IHC; ICC; IF.
Assay Kits CLW267Bo01 CLIA Kit for Immunoglobulin M (IgM) CLIA assay for Antigen Detection
ELW267Bo01 ELISA Kit for Immunoglobulin M (IgM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW267Rb01 Recombinant Immunoglobulin M (IgM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW267Rb01 Monoclonal Antibody to Immunoglobulin M (IgM) WB; IHC; ICC; IP.
PAW267Rb01 Polyclonal Antibody to Immunoglobulin M (IgM) WB; IHC; ICC; IF.
Assay Kits CLW267Rb01 CLIA Kit for Immunoglobulin M (IgM) CLIA assay for Antigen Detection
ELW267Rb01 ELISA Kit for Immunoglobulin M (IgM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW267Mo01 Recombinant Immunoglobulin M (IgM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW267Mo01 Monoclonal Antibody to Immunoglobulin M (IgM) WB; IHC; ICC; IP.
PAW267Mo01 Polyclonal Antibody to Immunoglobulin M (IgM) WB; IHC; ICC; IF.
Assay Kits CLW267Mo01 CLIA Kit for Immunoglobulin M (IgM) CLIA assay for Antigen Detection
ELW267Mo01 ELISA Kit for Immunoglobulin M (IgM) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The complete nucleotide sequence of a human immunoglobulin genomic C mu gene."
Nucleic Acids Res. 17:6412-6412(1989) [PubMed] [Europe PMC] [Abstract]

"Complete nucleotide sequence of the membrane form of the human IgM heavy chain."
Nucleic Acids Res. 18:4278-4278(1990) [PubMed] [Europe PMC] [Abstract]

"The primary structure of a monoclonal IgM-immunoglobulin (macroglobulin Gal.), II: the amino acid sequence of the H-chain (mu-type), subgroup H III. Architecture of the complete IgM-molecule."
Hoppe-Seyler's Z. Physiol. Chem. 354:1505-1509(1973) [PubMed] [Europe PMC] [Abstract]

"The primary structure of the constant part of mu-chain-disease protein BOT."
Eur. J. Biochem. 111:275-286(1980) [PubMed] [Europe PMC] [Abstract]

"Complete amino acid sequence of the Mu heavy chain of a human IgM immunoglobulin."
Science 182:287-291(1973) [PubMed] [Europe PMC] [Abstract]

"Cloning and partial nucleotide sequence of human immunoglobulin mu chain cDNA from B cells and mouse-human hybridomas."
Proc. Natl. Acad. Sci. U.S.A. 77:6027-6031(1980) [PubMed] [Europe PMC] [Abstract]

"Human immunoglobulin heavy chain genes: evolutionary comparisons of C mu, C delta and C gamma genes and associated switch sequences."
Nucleic Acids Res. 9:4509-4524(1981) [PubMed] [Europe PMC] [Abstract]

"Functional differences between immunoglobulins M and D expressed on the surface of an immature B-cell line."
Proc. Natl. Acad. Sci. U.S.A. 85:6914-6918(1988) [PubMed] [Europe PMC] [Abstract]

"Mutations in the mu heavy-chain gene in patients with agammaglobulinemia."
N. Engl. J. Med. 335:1486-1493(1996) [PubMed] [Europe PMC] [Abstract]

"The riddle of the dual expression of IgM and IgD."
Immunology 118:429-437(2006) [PubMed] [Europe PMC] [Abstract]

"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]