Vascular Cell Adhesion Molecule 1 (VCAM1)
CD106; INCAM-100; L1CAM
VCAM-1 (CD106), a member of the immunoglobulin superfamily, is a cell surface protein expressed by activated endothelial cells and certain leukocytes (such as macrophages). VCAM-1 expression is induced by IL-1β, IL-4, TNF-α and IFN-γ. VCAM-1 binds to leukocyte integrins VLA-4 and α4β7. The rat and mouse SVCAM-1 proteins share approximately 76% amino acid similarity.
VCAM-1 is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW263Hu01 | Recombinant Vascular Cell Adhesion Molecule 1 (VCAM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW263Hu01 | Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) | WB; IHC; ICC; IP. |
| PAW263Hu01 | Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW263Hu01 | CLIA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) | CLIA assay for Antigen Detection |
| ELW263Hu01 | ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW263Mu01 | Recombinant Vascular Cell Adhesion Molecule 1 (VCAM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW263Mu01 | Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) | WB; IHC; ICC; IP. |
| PAW263Mu01 | Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW263Mu01 | CLIA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) | CLIA assay for Antigen Detection |
| ELW263Mu01 | ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW263Ra01 | Recombinant Vascular Cell Adhesion Molecule 1 (VCAM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW263Ra01 | Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) | WB; IHC; ICC; IP. |
| PAW263Ra01 | Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW263Ra01 | CLIA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) | CLIA assay for Antigen Detection |
| ELW263Ra01 | ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW263Ca01 | Recombinant Vascular Cell Adhesion Molecule 1 (VCAM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW263Ca01 | Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) | WB; IHC; ICC; IP. |
| PAW263Ca01 | Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW263Ca01 | CLIA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) | CLIA assay for Antigen Detection |
| ELW263Ca01 | ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW263Po01 | Recombinant Vascular Cell Adhesion Molecule 1 (VCAM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW263Po01 | Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) | WB; IHC; ICC; IP. |
| PAW263Po01 | Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW263Po01 | CLIA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) | CLIA assay for Antigen Detection |
| ELW263Po01 | ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW263Bo01 | Recombinant Vascular Cell Adhesion Molecule 1 (VCAM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW263Bo01 | Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) | WB; IHC; ICC; IP. |
| PAW263Bo01 | Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW263Bo01 | CLIA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) | CLIA assay for Antigen Detection |
| ELW263Bo01 | ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW263Rb01 | Recombinant Vascular Cell Adhesion Molecule 1 (VCAM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW263Rb01 | Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) | WB; IHC; ICC; IP. |
| PAW263Rb01 | Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW263Rb01 | CLIA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) | CLIA assay for Antigen Detection |
| ELW263Rb01 | ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW263Mo01 | Recombinant Vascular Cell Adhesion Molecule 1 (VCAM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW263Mo01 | Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) | WB; IHC; ICC; IP. |
| PAW263Mo01 | Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW263Mo01 | CLIA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) | CLIA assay for Antigen Detection |
| ELW263Mo01 | ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Cell 59:1203-1211(1989) [PubMed] [Europe PMC] [Abstract]
"Full length vascular cell adhesion molecule 1 (VCAM-1)."
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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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"Activated endothelium binds lymphocytes through a novel binding site in the alternately spliced domain of vascular cell adhesion molecule-1."
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"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
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"Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8-A resolution."
Nature 373:539-544(1995) [PubMed] [Europe PMC] [Abstract]
"The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction."
Proc. Natl. Acad. Sci. U.S.A. 92:5714-5718(1995) [PubMed] [Europe PMC] [Abstract]
"Structure of a functional fragment of VCAM-1 refined at 1.9-A resolution."
Acta Crystallogr. D 52:369-379(1996) [PubMed] [Europe PMC] [Abstract]