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Macrophage Inflammatory Protein 5 (MIP5)

CCL15; SCYA15; HCC-2; NCC-3; SCYL3; Lkn-1; MIP1-D; MIP1d; MIP-1d; HMRP-2B; Leukotactin-1; Chemokine C-C-Motif Ligand 15; MIP-1 Delta; Small-inducible cytokine A15

Chemokine (C-C motif) ligand 15 (CCL15) is a small cytokine belonging to the CC chemokine family that is also known as leukotactin-1, MIP5 and HCC-2. CCL15 is expressed in liver, small intestine, colon, and in certain leukocytes and macrophages of the lung. It is chemotactic for neutrophils, monocytes, and lymphocytes and elicits its effects by binding to cell surface chemokine receptors like CCR1 and CCR3.

The human CCL15 gene spans four exons and is located in a head-to-tail orientation on chromosome 17 with the gene of another CC chemokine known as CCL14.Chemokines are secreted proteins involved in immunoregulatory and inflammatory processes. The putative mature LKN1 is composed of 92 amino acids with a calculated molecular mass of 10,162 Da.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW260Hu01 Recombinant Macrophage Inflammatory Protein 5 (MIP5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW260Hu01 Monoclonal Antibody to Macrophage Inflammatory Protein 5 (MIP5) WB; IHC; ICC; IP.
PAW260Hu01 Polyclonal Antibody to Macrophage Inflammatory Protein 5 (MIP5) WB; IHC; ICC; IF.
Assay Kits CLW260Hu01 CLIA Kit for Macrophage Inflammatory Protein 5 (MIP5) CLIA assay for Antigen Detection
ELW260Hu01 ELISA Kit for Macrophage Inflammatory Protein 5 (MIP5) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW260Mu01 Recombinant Macrophage Inflammatory Protein 5 (MIP5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW260Mu01 Monoclonal Antibody to Macrophage Inflammatory Protein 5 (MIP5) WB; IHC; ICC; IP.
PAW260Mu01 Polyclonal Antibody to Macrophage Inflammatory Protein 5 (MIP5) WB; IHC; ICC; IF.
Assay Kits CLW260Mu01 CLIA Kit for Macrophage Inflammatory Protein 5 (MIP5) CLIA assay for Antigen Detection
ELW260Mu01 ELISA Kit for Macrophage Inflammatory Protein 5 (MIP5) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW260Ra01 Recombinant Macrophage Inflammatory Protein 5 (MIP5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW260Ra01 Monoclonal Antibody to Macrophage Inflammatory Protein 5 (MIP5) WB; IHC; ICC; IP.
PAW260Ra01 Polyclonal Antibody to Macrophage Inflammatory Protein 5 (MIP5) WB; IHC; ICC; IF.
Assay Kits CLW260Ra01 CLIA Kit for Macrophage Inflammatory Protein 5 (MIP5) CLIA assay for Antigen Detection
ELW260Ra01 ELISA Kit for Macrophage Inflammatory Protein 5 (MIP5) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW260Ca01 Recombinant Macrophage Inflammatory Protein 5 (MIP5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW260Ca01 Monoclonal Antibody to Macrophage Inflammatory Protein 5 (MIP5) WB; IHC; ICC; IP.
PAW260Ca01 Polyclonal Antibody to Macrophage Inflammatory Protein 5 (MIP5) WB; IHC; ICC; IF.
Assay Kits CLW260Ca01 CLIA Kit for Macrophage Inflammatory Protein 5 (MIP5) CLIA assay for Antigen Detection
ELW260Ca01 ELISA Kit for Macrophage Inflammatory Protein 5 (MIP5) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW260Po01 Recombinant Macrophage Inflammatory Protein 5 (MIP5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW260Po01 Monoclonal Antibody to Macrophage Inflammatory Protein 5 (MIP5) WB; IHC; ICC; IP.
PAW260Po01 Polyclonal Antibody to Macrophage Inflammatory Protein 5 (MIP5) WB; IHC; ICC; IF.
Assay Kits CLW260Po01 CLIA Kit for Macrophage Inflammatory Protein 5 (MIP5) CLIA assay for Antigen Detection
ELW260Po01 ELISA Kit for Macrophage Inflammatory Protein 5 (MIP5) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW260Bo01 Recombinant Macrophage Inflammatory Protein 5 (MIP5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW260Bo01 Monoclonal Antibody to Macrophage Inflammatory Protein 5 (MIP5) WB; IHC; ICC; IP.
PAW260Bo01 Polyclonal Antibody to Macrophage Inflammatory Protein 5 (MIP5) WB; IHC; ICC; IF.
Assay Kits CLW260Bo01 CLIA Kit for Macrophage Inflammatory Protein 5 (MIP5) CLIA assay for Antigen Detection
ELW260Bo01 ELISA Kit for Macrophage Inflammatory Protein 5 (MIP5) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW260Rb01 Recombinant Macrophage Inflammatory Protein 5 (MIP5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW260Rb01 Monoclonal Antibody to Macrophage Inflammatory Protein 5 (MIP5) WB; IHC; ICC; IP.
PAW260Rb01 Polyclonal Antibody to Macrophage Inflammatory Protein 5 (MIP5) WB; IHC; ICC; IF.
Assay Kits CLW260Rb01 CLIA Kit for Macrophage Inflammatory Protein 5 (MIP5) CLIA assay for Antigen Detection
ELW260Rb01 ELISA Kit for Macrophage Inflammatory Protein 5 (MIP5) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW260Mo01 Recombinant Macrophage Inflammatory Protein 5 (MIP5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW260Mo01 Monoclonal Antibody to Macrophage Inflammatory Protein 5 (MIP5) WB; IHC; ICC; IP.
PAW260Mo01 Polyclonal Antibody to Macrophage Inflammatory Protein 5 (MIP5) WB; IHC; ICC; IF.
Assay Kits CLW260Mo01 CLIA Kit for Macrophage Inflammatory Protein 5 (MIP5) CLIA assay for Antigen Detection
ELW260Mo01 ELISA Kit for Macrophage Inflammatory Protein 5 (MIP5) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3."
J. Immunol. 159:5201-5205(1997) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and functional characterization of human MIP-1 delta, a new C-C chemokine related to mouse CCF-18 and C10."
J. Clin. Immunol. 18:214-222(1998) [PubMed] [Europe PMC] [Abstract]

"HCC-2, a human chemokine: gene structure, expression pattern, and biological activity."
Proc. Natl. Acad. Sci. U.S.A. 95:6308-6313(1998) [PubMed] [Europe PMC] [Abstract]

"Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES."
J. Interferon Cytokine Res. 19:227-234(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

, Submitted (JAN-1997) to UniProtKB

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases."
J. Leukoc. Biol. 61:545-550(1997) [PubMed] [Europe PMC] [Abstract]

"Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1."
Blood 91:3118-3126(1998) [PubMed] [Europe PMC] [Abstract]

"Proteolytic activation of alternative CCR1 ligands in inflammation."
J. Immunol. 174:7341-7351(2005) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the human CC chemokine 2: A monomeric representative of the CC chemokine subtype."
Biochemistry 38:5995-6002(1999) [PubMed] [Europe PMC] [Abstract]