Tissue Inhibitors Of Metalloproteinase 1 (TIMP1)
EPO; CLGI; EPA; HCI; Erythroid Potentiating Activity; Collagenase Inhibitor; Metalloproteinase inhibitor 1; Fibroblast collagenase inhibitor
TIMP metallopeptidase inhibitor 1, a member of the TIMP family. The glycoprotein is a natural inhibitor of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function.
Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW258Hu01 | Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW258Hu01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IP. |
| PAW258Hu01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW258Hu01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | CLIA assay for Antigen Detection |
| ELW258Hu01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW258Mu01 | Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW258Mu01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IP. |
| PAW258Mu01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW258Mu01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | CLIA assay for Antigen Detection |
| ELW258Mu01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW258Ra01 | Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW258Ra01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IP. |
| PAW258Ra01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW258Ra01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | CLIA assay for Antigen Detection |
| ELW258Ra01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW258Ca01 | Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW258Ca01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IP. |
| PAW258Ca01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW258Ca01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | CLIA assay for Antigen Detection |
| ELW258Ca01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW258Po01 | Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW258Po01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IP. |
| PAW258Po01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW258Po01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | CLIA assay for Antigen Detection |
| ELW258Po01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW258Bo01 | Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW258Bo01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IP. |
| PAW258Bo01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW258Bo01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | CLIA assay for Antigen Detection |
| ELW258Bo01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW258Rb01 | Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW258Rb01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IP. |
| PAW258Rb01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW258Rb01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | CLIA assay for Antigen Detection |
| ELW258Rb01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW258Mo01 | Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW258Mo01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IP. |
| PAW258Mo01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW258Mo01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | CLIA assay for Antigen Detection |
| ELW258Mo01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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"The intrinsic protein flexibility of endogenous protease inhibitor TIMP-1 controls its binding interface and affects its function."
Biochemistry 49:6184-6192(2010) [PubMed] [Europe PMC] [Abstract]
"Matrix metalloproteinase-10 (MMP10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure."
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