Telomerase Associated Protein 1 (TEP1)
TLP1; TP1; TROVE1; VAULT2; p240; TROVE Domain Family Member 1; Telomerase protein component 1; p80 telomerase homolog
Telomerase-associated protein 1 (TEP1) is a component of the telomerase ribonucleoprotein complex, which catalyzes the addition of new telomeres on the chromosome ends. This activity is mediated by the catalytic telomerase reverse transcriptase (TERT) and telomerase RNA component template (TERC).
The ribonucleoprotein complex responsible for telomerase activity had been purified only in ciliates. Purified tetrahymena telomerase contains an RNA and 2 protein components, p80 and p95. The p80 component can be specifically cross linked to telomerase RNA, whereas the p95 component binds and cross links to single-stranded, telomeric DNA (Harrington et al., 1997).
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW252Hu01 | Recombinant Telomerase Associated Protein 1 (TEP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW252Hu01 | Monoclonal Antibody to Telomerase Associated Protein 1 (TEP1) | WB; IHC; ICC; IP. |
| PAW252Hu01 | Polyclonal Antibody to Telomerase Associated Protein 1 (TEP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW252Hu01 | CLIA Kit for Telomerase Associated Protein 1 (TEP1) | CLIA assay for Antigen Detection |
| ELW252Hu01 | ELISA Kit for Telomerase Associated Protein 1 (TEP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW252Mu01 | Recombinant Telomerase Associated Protein 1 (TEP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW252Mu01 | Monoclonal Antibody to Telomerase Associated Protein 1 (TEP1) | WB; IHC; ICC; IP. |
| PAW252Mu01 | Polyclonal Antibody to Telomerase Associated Protein 1 (TEP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW252Mu01 | CLIA Kit for Telomerase Associated Protein 1 (TEP1) | CLIA assay for Antigen Detection |
| ELW252Mu01 | ELISA Kit for Telomerase Associated Protein 1 (TEP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW252Ra01 | Recombinant Telomerase Associated Protein 1 (TEP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW252Ra01 | Monoclonal Antibody to Telomerase Associated Protein 1 (TEP1) | WB; IHC; ICC; IP. |
| PAW252Ra01 | Polyclonal Antibody to Telomerase Associated Protein 1 (TEP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW252Ra01 | CLIA Kit for Telomerase Associated Protein 1 (TEP1) | CLIA assay for Antigen Detection |
| ELW252Ra01 | ELISA Kit for Telomerase Associated Protein 1 (TEP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW252Ca01 | Recombinant Telomerase Associated Protein 1 (TEP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW252Ca01 | Monoclonal Antibody to Telomerase Associated Protein 1 (TEP1) | WB; IHC; ICC; IP. |
| PAW252Ca01 | Polyclonal Antibody to Telomerase Associated Protein 1 (TEP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW252Ca01 | CLIA Kit for Telomerase Associated Protein 1 (TEP1) | CLIA assay for Antigen Detection |
| ELW252Ca01 | ELISA Kit for Telomerase Associated Protein 1 (TEP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW252Po01 | Recombinant Telomerase Associated Protein 1 (TEP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW252Po01 | Monoclonal Antibody to Telomerase Associated Protein 1 (TEP1) | WB; IHC; ICC; IP. |
| PAW252Po01 | Polyclonal Antibody to Telomerase Associated Protein 1 (TEP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW252Po01 | CLIA Kit for Telomerase Associated Protein 1 (TEP1) | CLIA assay for Antigen Detection |
| ELW252Po01 | ELISA Kit for Telomerase Associated Protein 1 (TEP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW252Bo01 | Recombinant Telomerase Associated Protein 1 (TEP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW252Bo01 | Monoclonal Antibody to Telomerase Associated Protein 1 (TEP1) | WB; IHC; ICC; IP. |
| PAW252Bo01 | Polyclonal Antibody to Telomerase Associated Protein 1 (TEP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW252Bo01 | CLIA Kit for Telomerase Associated Protein 1 (TEP1) | CLIA assay for Antigen Detection |
| ELW252Bo01 | ELISA Kit for Telomerase Associated Protein 1 (TEP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW252Rb01 | Recombinant Telomerase Associated Protein 1 (TEP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW252Rb01 | Monoclonal Antibody to Telomerase Associated Protein 1 (TEP1) | WB; IHC; ICC; IP. |
| PAW252Rb01 | Polyclonal Antibody to Telomerase Associated Protein 1 (TEP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW252Rb01 | CLIA Kit for Telomerase Associated Protein 1 (TEP1) | CLIA assay for Antigen Detection |
| ELW252Rb01 | ELISA Kit for Telomerase Associated Protein 1 (TEP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW252Mo01 | Recombinant Telomerase Associated Protein 1 (TEP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW252Mo01 | Monoclonal Antibody to Telomerase Associated Protein 1 (TEP1) | WB; IHC; ICC; IP. |
| PAW252Mo01 | Polyclonal Antibody to Telomerase Associated Protein 1 (TEP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW252Mo01 | CLIA Kit for Telomerase Associated Protein 1 (TEP1) | CLIA assay for Antigen Detection |
| ELW252Mo01 | ELISA Kit for Telomerase Associated Protein 1 (TEP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A mammalian telomerase-associated protein."
Science 275:973-977(1997) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"Human telomerase contains evolutionarily conserved catalytic and structural subunits."
Genes Dev. 11:3109-3115(1997) [PubMed] [Europe PMC] [Abstract]
"Vaults and telomerase share a common subunit, TEP1."
J. Biol. Chem. 274:32712-32717(1999) [PubMed] [Europe PMC] [Abstract]
"Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding."
Mol. Biol. Cell 11:3329-3340(2000) [PubMed] [Europe PMC] [Abstract]
"A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis."
Science 323:644-648(2009) [PubMed] [Europe PMC] [Abstract]