Interleukin 1 Beta (IL1b)
IL1-B; IL1-Beta; IL1F2; IL-1β; Interleukin-1 Family Member 2; Catabolin
Interleukin-1 (IL-1) is one of the first cytokines ever described. Its initial discovery was as a factor that could induce fever, control lymphocytes, increase the number of bone marrow cells and cause degeneration of bone joints. At this time, IL-1 was known under several other names including endogenous pyrogen, lymphocyte activating factor, haemopoetin-1 and mononuclear cell factor, amongst others.
It was around 1984-1985 when scientists confirmed that IL-1 was actually composed of two distinct proteins, now called IL-1α and IL-1β.These belong to a family of cytokines known as the interleukin-1 superfamily.Both IL-1α and IL-1β are produced by macrophages, monocytes and dendritic cells.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW247Hu01 | Recombinant Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW247Hu01 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. |
| PAW247Hu01 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW247Hu01 | CLIA Kit for Interleukin 1 Beta (IL1b) | CLIA assay for Antigen Detection |
| ELW247Hu01 | ELISA Kit for Interleukin 1 Beta (IL1b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW247Mu01 | Recombinant Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW247Mu01 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. |
| PAW247Mu01 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW247Mu01 | CLIA Kit for Interleukin 1 Beta (IL1b) | CLIA assay for Antigen Detection |
| ELW247Mu01 | ELISA Kit for Interleukin 1 Beta (IL1b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW247Ra01 | Recombinant Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW247Ra01 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. |
| PAW247Ra01 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW247Ra01 | CLIA Kit for Interleukin 1 Beta (IL1b) | CLIA assay for Antigen Detection |
| ELW247Ra01 | ELISA Kit for Interleukin 1 Beta (IL1b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW247Ca01 | Recombinant Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW247Ca01 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. |
| PAW247Ca01 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW247Ca01 | CLIA Kit for Interleukin 1 Beta (IL1b) | CLIA assay for Antigen Detection |
| ELW247Ca01 | ELISA Kit for Interleukin 1 Beta (IL1b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW247Po01 | Recombinant Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW247Po01 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. |
| PAW247Po01 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW247Po01 | CLIA Kit for Interleukin 1 Beta (IL1b) | CLIA assay for Antigen Detection |
| ELW247Po01 | ELISA Kit for Interleukin 1 Beta (IL1b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW247Bo01 | Recombinant Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW247Bo01 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. |
| PAW247Bo01 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW247Bo01 | CLIA Kit for Interleukin 1 Beta (IL1b) | CLIA assay for Antigen Detection |
| ELW247Bo01 | ELISA Kit for Interleukin 1 Beta (IL1b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW247Rb01 | Recombinant Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW247Rb01 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. |
| PAW247Rb01 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW247Rb01 | CLIA Kit for Interleukin 1 Beta (IL1b) | CLIA assay for Antigen Detection |
| ELW247Rb01 | ELISA Kit for Interleukin 1 Beta (IL1b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW247Mo01 | Recombinant Interleukin 1 Beta (IL1b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW247Mo01 | Monoclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IP. |
| PAW247Mo01 | Polyclonal Antibody to Interleukin 1 Beta (IL1b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW247Mo01 | CLIA Kit for Interleukin 1 Beta (IL1b) | CLIA assay for Antigen Detection |
| ELW247Mo01 | ELISA Kit for Interleukin 1 Beta (IL1b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Nucleotide sequence of human monocyte interleukin 1 precursor cDNA."
Proc. Natl. Acad. Sci. U.S.A. 81:7907-7911(1984) [PubMed] [Europe PMC] [Abstract]
"Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs."
Nature 315:641-647(1985) [PubMed] [Europe PMC] [Abstract]
"Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene."
Nucleic Acids Res. 14:7897-7914(1986) [PubMed] [Europe PMC] [Abstract]
Erratum
Nucleic Acids Res. 15:868-868(1987)
"cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line."
Biochem. Biophys. Res. Commun. 143:345-352(1987) [PubMed] [Europe PMC] [Abstract]
"Human interleukin-1 beta gene."
Gene 52:95-101(1987) [PubMed] [Europe PMC] [Abstract]
"Cloning of the cDNA coding for human prointerleukin-1 alpha and prointerleukin-1 beta."
Dokl. Akad. Nauk SSSR 309:1005-1008(1989) [PubMed] [Europe PMC] [Abstract]
"A sequence-based map of the nine genes of the human interleukin-1 cluster."
Genomics 79:718-725(2002) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase."
J. Exp. Med. 174:821-825(1991) [PubMed] [Europe PMC] [Abstract]
"Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1."
Nature 314:266-268(1985) [PubMed] [Europe PMC] [Abstract]
"Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow."
Blood 71:962-968(1988) [PubMed] [Europe PMC] [Abstract]
"The role of arginine residues in interleukin 1 receptor binding."
Biochim. Biophys. Acta 1118:25-35(1991) [PubMed] [Europe PMC] [Abstract]
"The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing."
Cell Death Differ. 14:1457-1466(2007) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the cytokine interleukin-1 beta."
EMBO J. 7:339-343(1988) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of recombinant human interleukin-1 beta at 2.0-A resolution."
J. Mol. Biol. 209:779-791(1989) [PubMed] [Europe PMC] [Abstract]
"Crystallographic refinement of interleukin 1 beta at 2.0-A resolution."
Proc. Natl. Acad. Sci. U.S.A. 86:9667-9671(1989) [PubMed] [Europe PMC] [Abstract]
"Determination of the secondary structure and molecular topology of interleukin-1 beta by use of two- and three-dimensional heteronuclear 15N-1H NMR spectroscopy."
Biochemistry 29:4668-4682(1990) [PubMed] [Europe PMC] [Abstract]
"High-resolution three-dimensional structure of interleukin 1 beta in solution by three- and four-dimensional nuclear magnetic resonance spectroscopy."
Biochemistry 30:2315-2323(1991) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta."
Nature 386:190-194(1997) [PubMed] [Europe PMC] [Abstract]
"Structural insights into the assembly and activation of IL-1beta with its receptors."
Nat. Immunol. 11:905-911(2010) [PubMed] [Europe PMC] [Abstract]