Interleukin 1 Delta (FIL1d)
IL1HY1; IL36RN; IL36Ra; IL1RP3; IL1L1; IL1F5; Interleukin 1 Family, Member 5; Interleukin-1 HY1; IL-1 Related Protein 3; Interleukin 36 Receptor Antagonist
PCR analysis revealed expression in leukocytes, spleen, and brain as well as in fetal brain and most abundantly in a fetal skin library. RT-PCR analysis also established that IL1HY1 expression is amplified in a stimulated macrophage cell line.
By EST database searching, Smith et al. (2000) also identified a cDNA encoding IL1HY1, which they termed FIL1-delta. Modeling indicated that IL1HY1 has a conserved 12-stranded beta-trefoil structure. By searching EST databases for IL1-like ligands, Busfield et al. (2000) also cloned IL1HY1, which they designated IL1RP3. SDS-PAGE analysis indicated that IL1HY1 is expressed as a 23-kD protein. Northern blot analysis detected expression of a 2.8-kb transcript in placenta and uterus. In situ hybridization analysis revealed constitutive expression by keratinocytes in vitro.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW244Hu01 | Recombinant Interleukin 1 Delta (FIL1d) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW244Hu01 | Monoclonal Antibody to Interleukin 1 Delta (FIL1d) | WB; IHC; ICC; IP. |
| PAW244Hu01 | Polyclonal Antibody to Interleukin 1 Delta (FIL1d) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW244Hu01 | CLIA Kit for Interleukin 1 Delta (FIL1d) | CLIA assay for Antigen Detection |
| ELW244Hu01 | ELISA Kit for Interleukin 1 Delta (FIL1d) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW244Mu01 | Recombinant Interleukin 1 Delta (FIL1d) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW244Mu01 | Monoclonal Antibody to Interleukin 1 Delta (FIL1d) | WB; IHC; ICC; IP. |
| PAW244Mu01 | Polyclonal Antibody to Interleukin 1 Delta (FIL1d) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW244Mu01 | CLIA Kit for Interleukin 1 Delta (FIL1d) | CLIA assay for Antigen Detection |
| ELW244Mu01 | ELISA Kit for Interleukin 1 Delta (FIL1d) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW244Ra01 | Recombinant Interleukin 1 Delta (FIL1d) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW244Ra01 | Monoclonal Antibody to Interleukin 1 Delta (FIL1d) | WB; IHC; ICC; IP. |
| PAW244Ra01 | Polyclonal Antibody to Interleukin 1 Delta (FIL1d) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW244Ra01 | CLIA Kit for Interleukin 1 Delta (FIL1d) | CLIA assay for Antigen Detection |
| ELW244Ra01 | ELISA Kit for Interleukin 1 Delta (FIL1d) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW244Ca01 | Recombinant Interleukin 1 Delta (FIL1d) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW244Ca01 | Monoclonal Antibody to Interleukin 1 Delta (FIL1d) | WB; IHC; ICC; IP. |
| PAW244Ca01 | Polyclonal Antibody to Interleukin 1 Delta (FIL1d) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW244Ca01 | CLIA Kit for Interleukin 1 Delta (FIL1d) | CLIA assay for Antigen Detection |
| ELW244Ca01 | ELISA Kit for Interleukin 1 Delta (FIL1d) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW244Po01 | Recombinant Interleukin 1 Delta (FIL1d) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW244Po01 | Monoclonal Antibody to Interleukin 1 Delta (FIL1d) | WB; IHC; ICC; IP. |
| PAW244Po01 | Polyclonal Antibody to Interleukin 1 Delta (FIL1d) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW244Po01 | CLIA Kit for Interleukin 1 Delta (FIL1d) | CLIA assay for Antigen Detection |
| ELW244Po01 | ELISA Kit for Interleukin 1 Delta (FIL1d) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW244Bo01 | Recombinant Interleukin 1 Delta (FIL1d) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW244Bo01 | Monoclonal Antibody to Interleukin 1 Delta (FIL1d) | WB; IHC; ICC; IP. |
| PAW244Bo01 | Polyclonal Antibody to Interleukin 1 Delta (FIL1d) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW244Bo01 | CLIA Kit for Interleukin 1 Delta (FIL1d) | CLIA assay for Antigen Detection |
| ELW244Bo01 | ELISA Kit for Interleukin 1 Delta (FIL1d) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW244Rb01 | Recombinant Interleukin 1 Delta (FIL1d) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW244Rb01 | Monoclonal Antibody to Interleukin 1 Delta (FIL1d) | WB; IHC; ICC; IP. |
| PAW244Rb01 | Polyclonal Antibody to Interleukin 1 Delta (FIL1d) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW244Rb01 | CLIA Kit for Interleukin 1 Delta (FIL1d) | CLIA assay for Antigen Detection |
| ELW244Rb01 | ELISA Kit for Interleukin 1 Delta (FIL1d) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW244Mo01 | Recombinant Interleukin 1 Delta (FIL1d) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW244Mo01 | Monoclonal Antibody to Interleukin 1 Delta (FIL1d) | WB; IHC; ICC; IP. |
| PAW244Mo01 | Polyclonal Antibody to Interleukin 1 Delta (FIL1d) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW244Mo01 | CLIA Kit for Interleukin 1 Delta (FIL1d) | CLIA assay for Antigen Detection |
| ELW244Mo01 | ELISA Kit for Interleukin 1 Delta (FIL1d) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Four new members expand the IL-1 superfamily."
J. Biol. Chem. 275:1169-1175(2000) [PubMed] [Europe PMC] [Abstract]
"IL1HY1: a novel interleukin-1 receptor antagonist gene."
Biochem. Biophys. Res. Commun. 263:702-706(1999) [PubMed] [Europe PMC] [Abstract]
"A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities."
Eur. J. Immunol. 30:3299-3308(2000) [PubMed] [Europe PMC] [Abstract]
"Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2."
J. Immunol. 167:1440-1446(2001) [PubMed] [Europe PMC] [Abstract]
"Identification and gene organization of three novel members of the IL-1 family on human chromosome 2."
Genomics 66:213-216(2000) [PubMed] [Europe PMC] [Abstract]
"A sequence-based map of the nine genes of the human interleukin-1 cluster."
Genomics 79:718-725(2002) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity."
J. Biol. Chem. 286:42594-42602(2011) [PubMed] [Europe PMC] [Abstract]
"The IL-36 receptor pathway regulates Aspergillus fumigatus-induced Th1 and Th17 responses."
Eur. J. Immunol. 43:416-426(2013) [PubMed] [Europe PMC] [Abstract]
"Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis."
Am. J. Hum. Genet. 89:432-437(2011) [PubMed] [Europe PMC] [Abstract]
"Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis."
N. Engl. J. Med. 365:620-628(2011) [PubMed] [Europe PMC] [Abstract]
"Mutation analysis of the IL36RN gene in 14 Japanese patients with generalized pustular psoriasis."
Hum. Mutat. 34:176-183(2013) [PubMed] [Europe PMC] [Abstract]