S100 Calcium Binding Protein B (S100B)
S100-B; NEF; S100Beta; S-100 protein subunit beta
S100 proteins are localized in the cytoplasm and nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100B is glial-specific and is expressed primarily by astrocytes, but not all astrocytes express S100B. It has been shown that S100B is only expressed by a subtype of mature astrocytes that ensheath blood vessels and by NG2-expressing cells. This protein may function in neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. In the developing CNS it acts as a neurotrophic factor and neuronal survival protein.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW243Hu01 | Recombinant S100 Calcium Binding Protein B (S100B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW243Hu01 | Monoclonal Antibody to S100 Calcium Binding Protein B (S100B) | WB; IHC; ICC; IP. |
| PAW243Hu01 | Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW243Hu01 | CLIA Kit for S100 Calcium Binding Protein B (S100B) | CLIA assay for Antigen Detection |
| ELW243Hu01 | ELISA Kit for S100 Calcium Binding Protein B (S100B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW243Mu01 | Recombinant S100 Calcium Binding Protein B (S100B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW243Mu01 | Monoclonal Antibody to S100 Calcium Binding Protein B (S100B) | WB; IHC; ICC; IP. |
| PAW243Mu01 | Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW243Mu01 | CLIA Kit for S100 Calcium Binding Protein B (S100B) | CLIA assay for Antigen Detection |
| ELW243Mu01 | ELISA Kit for S100 Calcium Binding Protein B (S100B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW243Ra01 | Recombinant S100 Calcium Binding Protein B (S100B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW243Ra01 | Monoclonal Antibody to S100 Calcium Binding Protein B (S100B) | WB; IHC; ICC; IP. |
| PAW243Ra01 | Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW243Ra01 | CLIA Kit for S100 Calcium Binding Protein B (S100B) | CLIA assay for Antigen Detection |
| ELW243Ra01 | ELISA Kit for S100 Calcium Binding Protein B (S100B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW243Ca01 | Recombinant S100 Calcium Binding Protein B (S100B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW243Ca01 | Monoclonal Antibody to S100 Calcium Binding Protein B (S100B) | WB; IHC; ICC; IP. |
| PAW243Ca01 | Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW243Ca01 | CLIA Kit for S100 Calcium Binding Protein B (S100B) | CLIA assay for Antigen Detection |
| ELW243Ca01 | ELISA Kit for S100 Calcium Binding Protein B (S100B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW243Po01 | Recombinant S100 Calcium Binding Protein B (S100B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW243Po01 | Monoclonal Antibody to S100 Calcium Binding Protein B (S100B) | WB; IHC; ICC; IP. |
| PAW243Po01 | Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW243Po01 | CLIA Kit for S100 Calcium Binding Protein B (S100B) | CLIA assay for Antigen Detection |
| ELW243Po01 | ELISA Kit for S100 Calcium Binding Protein B (S100B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW243Bo01 | Recombinant S100 Calcium Binding Protein B (S100B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW243Bo01 | Monoclonal Antibody to S100 Calcium Binding Protein B (S100B) | WB; IHC; ICC; IP. |
| PAW243Bo01 | Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW243Bo01 | CLIA Kit for S100 Calcium Binding Protein B (S100B) | CLIA assay for Antigen Detection |
| ELW243Bo01 | ELISA Kit for S100 Calcium Binding Protein B (S100B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW243Rb01 | Recombinant S100 Calcium Binding Protein B (S100B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW243Rb01 | Monoclonal Antibody to S100 Calcium Binding Protein B (S100B) | WB; IHC; ICC; IP. |
| PAW243Rb01 | Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW243Rb01 | CLIA Kit for S100 Calcium Binding Protein B (S100B) | CLIA assay for Antigen Detection |
| ELW243Rb01 | ELISA Kit for S100 Calcium Binding Protein B (S100B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW243Mo01 | Recombinant S100 Calcium Binding Protein B (S100B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW243Mo01 | Monoclonal Antibody to S100 Calcium Binding Protein B (S100B) | WB; IHC; ICC; IP. |
| PAW243Mo01 | Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW243Mo01 | CLIA Kit for S100 Calcium Binding Protein B (S100B) | CLIA assay for Antigen Detection |
| ELW243Mo01 | ELISA Kit for S100 Calcium Binding Protein B (S100B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning and expression of the human S100 beta gene."
J. Biol. Chem. 265:15537-15543(1990) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 21."
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Characterization of human brain S100 protein fraction: amino acid sequence of S100 beta."
J. Neurochem. 45:700-705(1985) [PubMed] [Europe PMC] [Abstract]
"Purification, characterization and ion binding properties of human brain S100b protein."
Biochim. Biophys. Acta 790:164-173(1984) [PubMed] [Europe PMC] [Abstract]
"Demonstration of heterodimer formation between S100B and S100A6 in the yeast two-hybrid system and human melanoma."
Exp. Cell Res. 246:501-509(1999) [PubMed] [Europe PMC] [Abstract]
"The 1.5 A crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding."
J. Biol. Chem. 285:40762-40770(2010) [PubMed] [Europe PMC] [Abstract]
"The calcium-dependent interaction between S100B and the mitochondrial AAA ATPase ATAD3A and the role of this complex in the cytoplasmic processing of ATAD3A."
Mol. Cell. Biol. 30:2724-2736(2010) [PubMed] [Europe PMC] [Abstract]
"S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation."
J. Biol. Chem. 287:13787-13798(2012) [PubMed] [Europe PMC] [Abstract]
"A novel calcium-sensitive switch revealed by the structure of human S100B in the calcium-bound form."
Structure 6:211-222(1998) [PubMed] [Europe PMC] [Abstract]
"A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex."
J. Biol. Chem. 278:6251-6257(2003) [PubMed] [Europe PMC] [Abstract]