Aquaporin 4 (AQP4)
HMIWC2; MIWC; WCH4; Mercurial-insensitive water channel
Aquaporin-4 (AQP4), is a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Aquaporin-4 is located in many tissues, including the basolateral membrane of the renal cortical and medullary principal cell, as well as in the brain.Aquaporin-4 is the first specific molecule to be defined as a target for the autoimmune response in any form of multiple sclerosis. Aquaporin 4 is found in the basolateral cell membrane of principal collecting duct cells and provide a pathway for water to exit these cells.AQP4 is also expressed in astrocytes and is upregulated by direct insult to the central nervous system.Aquaporin-4 has been proposed as the primary autoimmune target in Devic's disease.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW228Hu01 | Recombinant Aquaporin 4 (AQP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW228Hu01 | Monoclonal Antibody to Aquaporin 4 (AQP4) | WB; IHC; ICC; IP. |
| PAW228Hu01 | Polyclonal Antibody to Aquaporin 4 (AQP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW228Hu01 | CLIA Kit for Aquaporin 4 (AQP4) | CLIA assay for Antigen Detection |
| ELW228Hu01 | ELISA Kit for Aquaporin 4 (AQP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW228Mu01 | Recombinant Aquaporin 4 (AQP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW228Mu01 | Monoclonal Antibody to Aquaporin 4 (AQP4) | WB; IHC; ICC; IP. |
| PAW228Mu01 | Polyclonal Antibody to Aquaporin 4 (AQP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW228Mu01 | CLIA Kit for Aquaporin 4 (AQP4) | CLIA assay for Antigen Detection |
| ELW228Mu01 | ELISA Kit for Aquaporin 4 (AQP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW228Ra01 | Recombinant Aquaporin 4 (AQP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW228Ra01 | Monoclonal Antibody to Aquaporin 4 (AQP4) | WB; IHC; ICC; IP. |
| PAW228Ra01 | Polyclonal Antibody to Aquaporin 4 (AQP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW228Ra01 | CLIA Kit for Aquaporin 4 (AQP4) | CLIA assay for Antigen Detection |
| ELW228Ra01 | ELISA Kit for Aquaporin 4 (AQP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW228Ca01 | Recombinant Aquaporin 4 (AQP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW228Ca01 | Monoclonal Antibody to Aquaporin 4 (AQP4) | WB; IHC; ICC; IP. |
| PAW228Ca01 | Polyclonal Antibody to Aquaporin 4 (AQP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW228Ca01 | CLIA Kit for Aquaporin 4 (AQP4) | CLIA assay for Antigen Detection |
| ELW228Ca01 | ELISA Kit for Aquaporin 4 (AQP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW228Po01 | Recombinant Aquaporin 4 (AQP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW228Po01 | Monoclonal Antibody to Aquaporin 4 (AQP4) | WB; IHC; ICC; IP. |
| PAW228Po01 | Polyclonal Antibody to Aquaporin 4 (AQP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW228Po01 | CLIA Kit for Aquaporin 4 (AQP4) | CLIA assay for Antigen Detection |
| ELW228Po01 | ELISA Kit for Aquaporin 4 (AQP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW228Bo01 | Recombinant Aquaporin 4 (AQP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW228Bo01 | Monoclonal Antibody to Aquaporin 4 (AQP4) | WB; IHC; ICC; IP. |
| PAW228Bo01 | Polyclonal Antibody to Aquaporin 4 (AQP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW228Bo01 | CLIA Kit for Aquaporin 4 (AQP4) | CLIA assay for Antigen Detection |
| ELW228Bo01 | ELISA Kit for Aquaporin 4 (AQP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW228Rb01 | Recombinant Aquaporin 4 (AQP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW228Rb01 | Monoclonal Antibody to Aquaporin 4 (AQP4) | WB; IHC; ICC; IP. |
| PAW228Rb01 | Polyclonal Antibody to Aquaporin 4 (AQP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW228Rb01 | CLIA Kit for Aquaporin 4 (AQP4) | CLIA assay for Antigen Detection |
| ELW228Rb01 | ELISA Kit for Aquaporin 4 (AQP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW228Mo01 | Recombinant Aquaporin 4 (AQP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW228Mo01 | Monoclonal Antibody to Aquaporin 4 (AQP4) | WB; IHC; ICC; IP. |
| PAW228Mo01 | Polyclonal Antibody to Aquaporin 4 (AQP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW228Mo01 | CLIA Kit for Aquaporin 4 (AQP4) | CLIA assay for Antigen Detection |
| ELW228Mo01 | ELISA Kit for Aquaporin 4 (AQP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel. Evidence for distinct transcriptional units."
J. Biol. Chem. 270:22907-22913(1995) [PubMed] [Europe PMC] [Abstract]
"A water channel closely related to rat brain aquaporin 4 is expressed in acid- and pepsinogen-secretory cells of human stomach."
FEBS Lett. 381:208-212(1996) [PubMed] [Europe PMC] [Abstract]
"The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain."
Proc. Natl. Acad. Sci. U.S.A. 93:10908-10912(1996) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 18."
Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Megalencephalic leukoencephalopathy with subcortical cysts protein 1 functionally cooperates with the TRPV4 cation channel to activate the response of astrocytes to osmotic stress: dysregulation by pathological mutations."
Hum. Mol. Genet. 21:2166-2180(2012) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance."
Proc. Natl. Acad. Sci. U.S.A. 106:7437-7442(2009) [PubMed] [Europe PMC] [Abstract]