Call Now

Adiponectin (ADP)

GBP28; ApM1; AdipoQ; Acrp30; ACDC; APM1; C1Q And Collagen Domain Containing; Adipocyte Complement-Related Protein Of 30 KDa; Adipose Most Abundant Gene Transcript 1

Adiponectin, alternatively named Adipocyte Complement-Related Protein of 30 kDa, shares structural similarity with complement factor C1q and is a member of the family of defense collagens. It is secreted exclusively by differentiated adipocytes and circulates at high concentrations. Adiponectin has a modular structure comprising an N-terminal collagenous domain with multiple collagen triple helix repeats, followed by a C-terminal C1q-like globular domain. The globular domain has similar folding topology with tumor necrosis factor-α and assembles into homotrimers. Higher order oligomeric adiponectins are also formed via interactions between the collagenous stalk. A truncated form of Adiponectin containing only the globular domain can be generated by proteolytic cleavage.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW205Hu01 Recombinant Adiponectin (ADP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW205Hu01 Monoclonal Antibody to Adiponectin (ADP) WB; IHC; ICC; IP.
PAW205Hu01 Polyclonal Antibody to Adiponectin (ADP) WB; IHC; ICC; IF.
Assay Kits CLW205Hu01 CLIA Kit for Adiponectin (ADP) CLIA assay for Antigen Detection
ELW205Hu01 ELISA Kit for Adiponectin (ADP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW205Mu01 Recombinant Adiponectin (ADP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW205Mu01 Monoclonal Antibody to Adiponectin (ADP) WB; IHC; ICC; IP.
PAW205Mu01 Polyclonal Antibody to Adiponectin (ADP) WB; IHC; ICC; IF.
Assay Kits CLW205Mu01 CLIA Kit for Adiponectin (ADP) CLIA assay for Antigen Detection
ELW205Mu01 ELISA Kit for Adiponectin (ADP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW205Ra01 Recombinant Adiponectin (ADP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW205Ra01 Monoclonal Antibody to Adiponectin (ADP) WB; IHC; ICC; IP.
PAW205Ra01 Polyclonal Antibody to Adiponectin (ADP) WB; IHC; ICC; IF.
Assay Kits CLW205Ra01 CLIA Kit for Adiponectin (ADP) CLIA assay for Antigen Detection
ELW205Ra01 ELISA Kit for Adiponectin (ADP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW205Ca01 Recombinant Adiponectin (ADP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW205Ca01 Monoclonal Antibody to Adiponectin (ADP) WB; IHC; ICC; IP.
PAW205Ca01 Polyclonal Antibody to Adiponectin (ADP) WB; IHC; ICC; IF.
Assay Kits CLW205Ca01 CLIA Kit for Adiponectin (ADP) CLIA assay for Antigen Detection
ELW205Ca01 ELISA Kit for Adiponectin (ADP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW205Po01 Recombinant Adiponectin (ADP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW205Po01 Monoclonal Antibody to Adiponectin (ADP) WB; IHC; ICC; IP.
PAW205Po01 Polyclonal Antibody to Adiponectin (ADP) WB; IHC; ICC; IF.
Assay Kits CLW205Po01 CLIA Kit for Adiponectin (ADP) CLIA assay for Antigen Detection
ELW205Po01 ELISA Kit for Adiponectin (ADP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW205Bo01 Recombinant Adiponectin (ADP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW205Bo01 Monoclonal Antibody to Adiponectin (ADP) WB; IHC; ICC; IP.
PAW205Bo01 Polyclonal Antibody to Adiponectin (ADP) WB; IHC; ICC; IF.
Assay Kits CLW205Bo01 CLIA Kit for Adiponectin (ADP) CLIA assay for Antigen Detection
ELW205Bo01 ELISA Kit for Adiponectin (ADP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW205Rb01 Recombinant Adiponectin (ADP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW205Rb01 Monoclonal Antibody to Adiponectin (ADP) WB; IHC; ICC; IP.
PAW205Rb01 Polyclonal Antibody to Adiponectin (ADP) WB; IHC; ICC; IF.
Assay Kits CLW205Rb01 CLIA Kit for Adiponectin (ADP) CLIA assay for Antigen Detection
ELW205Rb01 ELISA Kit for Adiponectin (ADP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW205Mo01 Recombinant Adiponectin (ADP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW205Mo01 Monoclonal Antibody to Adiponectin (ADP) WB; IHC; ICC; IP.
PAW205Mo01 Polyclonal Antibody to Adiponectin (ADP) WB; IHC; ICC; IF.
Assay Kits CLW205Mo01 CLIA Kit for Adiponectin (ADP) CLIA assay for Antigen Detection
ELW205Mo01 ELISA Kit for Adiponectin (ADP) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1)."
Biochem. Biophys. Res. Commun. 221:286-289(1996) [PubMed] [Europe PMC] [Abstract]

"Organization of the gene for gelatin-binding protein (GBP28)."
Gene 229:67-73(1999) [PubMed] [Europe PMC] [Abstract]

"The human apM-1, an adipocyte-specific gene linked to the family of TNF's and to genes expressed in activated T cells, is mapped to chromosome 1q21.3-q23, a susceptibility locus identified for familial combined hyperlipidemia (FCH)."
Biochem. Biophys. Res. Commun. 260:416-425(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma."
J. Biochem. 120:803-812(1996) [PubMed] [Europe PMC] [Abstract]

"Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages."
Blood 96:1723-1732(2000) [PubMed] [Europe PMC] [Abstract]

"Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway."
Circulation 102:1296-1301(2000) [PubMed] [Europe PMC] [Abstract]

"The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity."
Nat. Med. 7:941-946(2001) [PubMed] [Europe PMC] [Abstract]

"Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin."
J. Biol. Chem. 278:40352-40363(2003) [PubMed] [Europe PMC] [Abstract]

"Adiponectin multimerization is dependent on conserved lysines in the collagenous domain: evidence for regulation of multimerization by alterations in posttranslational modifications."
Mol. Endocrinol. 20:1673-1687(2006) [PubMed] [Europe PMC] [Abstract]

"Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation."
Mol. Endocrinol. 24:229-239(2010) [PubMed] [Europe PMC] [Abstract]

"Resveratrol-induced changes of the human adipocyte secretion profile."
J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of a single-chain trimer of human adiponectin globular domain."
FEBS Lett. 586:912-917(2012) [PubMed] [Europe PMC] [Abstract]

"Genomic structure and mutations in adipose-specific gene, adiponectin."
Int. J. Obes. Relat. Metab. Disord. 24:861-868(2000) [PubMed] [Europe PMC] [Abstract]

"Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population."
Diabetes 51:536-540(2002) [PubMed] [Europe PMC] [Abstract]

Erratum
Diabetes 51:1294-1294(2002)

"Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome."
Diabetes 51:2325-2328(2002) [PubMed] [Europe PMC] [Abstract]

"Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians."
Hum. Mol. Genet. 11:2607-2614(2002) [PubMed] [Europe PMC] [Abstract]