Glutathione S Transferase Omega 1 (GSTo1)

P28; GSTTLp28; GSTw1; SPG-R; Glutathione-dependent dehydroascorbate reductase; Monomethylarsonic acid reductase; MMA(V) reductase; S-(Phenacyl)glutathione reductase

SPN	W188
HGNC	13312
MGI	1342273
PubMed	20106899
RGD	70952
UniProt	P78417
Wiki	GSTO1

Glutathione S-transferase omega-1 is an enzyme that  encodes a member of the theta class glutathione S-transferase-like (GSTTL) protein family. In mouse, the encoded protein acts as a small stress response protein, likely involved in cellular redox homeostasis.This protein has dehydroascorbate reductase activity and may function in the glutathione-ascorbate cycle as part of antioxidant metabolism.

GSTO1 has an N-terminal thioredoxin-like domain consisting of a central 4-stranded beta sheet flanked on one side by 2 alpha helices and on the other by a 3-10 helix. The C terminus is composed of 7 alpha helices and makes several H bonds with the N-terminal domain. GSTO1 forms a dimer and adopts the typical GST tertiary structure.

Reference

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J. Biol. Chem. 275:24798-24806(2000) [PubMed] [Europe PMC] [Abstract]

"Genetic variation in genes associated with arsenic metabolism: glutathione S-transferase omega 1-1 and purine nucleoside phosphorylase polymorphisms in European and indigenous Americans."
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Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

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Electrophoresis 21:3785-3796(2000) [PubMed] [Europe PMC] [Abstract]

"Human monomethylarsonic acid (MMA(V)) reductase is a member of the glutathione-S-transferase superfamily."
Chem. Res. Toxicol. 14:1051-1057(2001) [PubMed] [Europe PMC] [Abstract]

"Glutathione transferase omega 1 catalyzes the reduction of S-(phenacyl)glutathiones to acetophenones."
Chem. Res. Toxicol. 20:149-154(2007) [PubMed] [Europe PMC] [Abstract]

"S-(4-Nitrophenacyl)glutathione is a specific substrate for glutathione transferase omega 1-1."
Anal. Biochem. 374:25-30(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

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BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Novel folding and stability defects cause a deficiency of human glutathione transferase omega 1."
J. Biol. Chem. 286:4271-4279(2011) [PubMed] [Europe PMC] [Abstract]

"Characterization of the human Omega class glutathione transferase genes and associated polymorphisms."
Pharmacogenetics 13:131-144(2003) [PubMed] [Europe PMC] [Abstract]