Chemokine C-X-C-Motif Receptor 3 (CXCR3)
CD183; CKR-L2; CMKAR3; GPR9; IP10r; IP10-R; Mig-R; MigR; G Protein-Coupled Receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor
CD183 (CXCR3) is a multi-pass type-3, 7 span 368 aa glycoprotein. It contains an extracellular domain which contains 3 potential amino-glycosylation sites, 7 putative transmembrane-spanning domains and an intracellular carboxyl-terminal regions which has 3 intracellular loop regions.
The intracellular carboxyl-terminal region contains 10 Thr/Ser residues that may become phosphorylated during CD183-mediated signaling. The DRYLAIVHA-motif in the 2nd intracellular loop is the most highly conserved sequence element in chemokine receptors. CD183 is a chemokine receptor which are G-proteins coupled receptors. CD183 shares a 30% identity with CD181 (CXCR1) and CD182 (CXCR2).
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW186Hu01 | Recombinant Chemokine C-X-C-Motif Receptor 3 (CXCR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW186Hu01 | Monoclonal Antibody to Chemokine C-X-C-Motif Receptor 3 (CXCR3) | WB; IHC; ICC; IP. |
| PAW186Hu01 | Polyclonal Antibody to Chemokine C-X-C-Motif Receptor 3 (CXCR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW186Hu01 | CLIA Kit for Chemokine C-X-C-Motif Receptor 3 (CXCR3) | CLIA assay for Antigen Detection |
| ELW186Hu01 | ELISA Kit for Chemokine C-X-C-Motif Receptor 3 (CXCR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW186Mu01 | Recombinant Chemokine C-X-C-Motif Receptor 3 (CXCR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW186Mu01 | Monoclonal Antibody to Chemokine C-X-C-Motif Receptor 3 (CXCR3) | WB; IHC; ICC; IP. |
| PAW186Mu01 | Polyclonal Antibody to Chemokine C-X-C-Motif Receptor 3 (CXCR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW186Mu01 | CLIA Kit for Chemokine C-X-C-Motif Receptor 3 (CXCR3) | CLIA assay for Antigen Detection |
| ELW186Mu01 | ELISA Kit for Chemokine C-X-C-Motif Receptor 3 (CXCR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW186Ra01 | Recombinant Chemokine C-X-C-Motif Receptor 3 (CXCR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW186Ra01 | Monoclonal Antibody to Chemokine C-X-C-Motif Receptor 3 (CXCR3) | WB; IHC; ICC; IP. |
| PAW186Ra01 | Polyclonal Antibody to Chemokine C-X-C-Motif Receptor 3 (CXCR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW186Ra01 | CLIA Kit for Chemokine C-X-C-Motif Receptor 3 (CXCR3) | CLIA assay for Antigen Detection |
| ELW186Ra01 | ELISA Kit for Chemokine C-X-C-Motif Receptor 3 (CXCR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW186Ca01 | Recombinant Chemokine C-X-C-Motif Receptor 3 (CXCR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW186Ca01 | Monoclonal Antibody to Chemokine C-X-C-Motif Receptor 3 (CXCR3) | WB; IHC; ICC; IP. |
| PAW186Ca01 | Polyclonal Antibody to Chemokine C-X-C-Motif Receptor 3 (CXCR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW186Ca01 | CLIA Kit for Chemokine C-X-C-Motif Receptor 3 (CXCR3) | CLIA assay for Antigen Detection |
| ELW186Ca01 | ELISA Kit for Chemokine C-X-C-Motif Receptor 3 (CXCR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW186Po01 | Recombinant Chemokine C-X-C-Motif Receptor 3 (CXCR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW186Po01 | Monoclonal Antibody to Chemokine C-X-C-Motif Receptor 3 (CXCR3) | WB; IHC; ICC; IP. |
| PAW186Po01 | Polyclonal Antibody to Chemokine C-X-C-Motif Receptor 3 (CXCR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW186Po01 | CLIA Kit for Chemokine C-X-C-Motif Receptor 3 (CXCR3) | CLIA assay for Antigen Detection |
| ELW186Po01 | ELISA Kit for Chemokine C-X-C-Motif Receptor 3 (CXCR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW186Bo01 | Recombinant Chemokine C-X-C-Motif Receptor 3 (CXCR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW186Bo01 | Monoclonal Antibody to Chemokine C-X-C-Motif Receptor 3 (CXCR3) | WB; IHC; ICC; IP. |
| PAW186Bo01 | Polyclonal Antibody to Chemokine C-X-C-Motif Receptor 3 (CXCR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW186Bo01 | CLIA Kit for Chemokine C-X-C-Motif Receptor 3 (CXCR3) | CLIA assay for Antigen Detection |
| ELW186Bo01 | ELISA Kit for Chemokine C-X-C-Motif Receptor 3 (CXCR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW186Rb01 | Recombinant Chemokine C-X-C-Motif Receptor 3 (CXCR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW186Rb01 | Monoclonal Antibody to Chemokine C-X-C-Motif Receptor 3 (CXCR3) | WB; IHC; ICC; IP. |
| PAW186Rb01 | Polyclonal Antibody to Chemokine C-X-C-Motif Receptor 3 (CXCR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW186Rb01 | CLIA Kit for Chemokine C-X-C-Motif Receptor 3 (CXCR3) | CLIA assay for Antigen Detection |
| ELW186Rb01 | ELISA Kit for Chemokine C-X-C-Motif Receptor 3 (CXCR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW186Mo01 | Recombinant Chemokine C-X-C-Motif Receptor 3 (CXCR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW186Mo01 | Monoclonal Antibody to Chemokine C-X-C-Motif Receptor 3 (CXCR3) | WB; IHC; ICC; IP. |
| PAW186Mo01 | Polyclonal Antibody to Chemokine C-X-C-Motif Receptor 3 (CXCR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW186Mo01 | CLIA Kit for Chemokine C-X-C-Motif Receptor 3 (CXCR3) | CLIA assay for Antigen Detection |
| ELW186Mo01 | ELISA Kit for Chemokine C-X-C-Motif Receptor 3 (CXCR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes."
J. Exp. Med. 184:963-969(1996) [PubMed] [Europe PMC] [Abstract]
"An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4."
J. Exp. Med. 197:1537-1549(2003) [PubMed] [Europe PMC] [Abstract]
"Activation of p38(MAPK) mediates the angiostatic effect of the chemokine receptor CXCR3-B."
Int. J. Biochem. Cell Biol. 40:1764-1774(2008) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors."
Genomics 29:335-344(1995) [PubMed] [Europe PMC] [Abstract]
"Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3."
Genes Immun. 1:330-337(2000) [PubMed] [Europe PMC] [Abstract]
"Identification and partial characterization of a variant of human CXCR3 generated by posttranscriptional exon skipping."
J. Immunol. 173:6234-6240(2004) [PubMed] [Europe PMC] [Abstract]
"Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3."
J. Exp. Med. 187:2009-2021(1998) [PubMed] [Europe PMC] [Abstract]
"CXCR3 requires tyrosine sulfation for ligand binding and a second extracellular loop arginine residue for ligand-induced chemotaxis."
Mol. Cell. Biol. 26:5838-5849(2006) [PubMed] [Europe PMC] [Abstract]
"Sulfated tyrosines 27 and 29 in the N-terminus of human CXCR3 participate in binding native IP-10."
Acta Pharmacol. Sin. 30:193-201(2009) [PubMed] [Europe PMC] [Abstract]
"CXCR3-B can mediate growth-inhibitory signals in human renal cancer cells by down-regulating the expression of heme oxygenase-1."
J. Biol. Chem. 285:36842-36848(2010) [PubMed] [Europe PMC] [Abstract]
"Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR."
Br. J. Pharmacol. 168:1375-1387(2013) [PubMed] [Europe PMC] [Abstract]