BH3 Interacting Domain Death Agonist (Bid)
p22 BID
BID is a pro-apoptotic Bcl-2 protein containing only the BH3 domain. In response to apoptotic signaling, BID interacts with another Bcl-2 family protein, Bax, leading to the insertion of Bax into organelle membranes, primarily the outer mitochondrial membrane. Bax is believed to interact with, and induce the opening of the mitochondrial voltage-dependent anion channel, VDAC. Alternatively, growing evidence suggest that activated Bax and/or Bak form an oligomeric pore, MAC in the outer membrane. This results in the release of cytochrome c and other pro-apoptotic factors from the mitochondria, often referred to as mitochondrial outer membrane permeabilization, leading to activation of caspases. This defines BID as a direct activator of Bax, a role common to some of the pro-apoptotic Bcl-2 proteins containing only the BH3 domain.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW182Hu01 | Recombinant BH3 Interacting Domain Death Agonist (Bid) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW182Hu01 | Monoclonal Antibody to BH3 Interacting Domain Death Agonist (Bid) | WB; IHC; ICC; IP. |
| PAW182Hu01 | Polyclonal Antibody to BH3 Interacting Domain Death Agonist (Bid) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW182Hu01 | CLIA Kit for BH3 Interacting Domain Death Agonist (Bid) | CLIA assay for Antigen Detection |
| ELW182Hu01 | ELISA Kit for BH3 Interacting Domain Death Agonist (Bid) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW182Mu01 | Recombinant BH3 Interacting Domain Death Agonist (Bid) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW182Mu01 | Monoclonal Antibody to BH3 Interacting Domain Death Agonist (Bid) | WB; IHC; ICC; IP. |
| PAW182Mu01 | Polyclonal Antibody to BH3 Interacting Domain Death Agonist (Bid) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW182Mu01 | CLIA Kit for BH3 Interacting Domain Death Agonist (Bid) | CLIA assay for Antigen Detection |
| ELW182Mu01 | ELISA Kit for BH3 Interacting Domain Death Agonist (Bid) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW182Ra01 | Recombinant BH3 Interacting Domain Death Agonist (Bid) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW182Ra01 | Monoclonal Antibody to BH3 Interacting Domain Death Agonist (Bid) | WB; IHC; ICC; IP. |
| PAW182Ra01 | Polyclonal Antibody to BH3 Interacting Domain Death Agonist (Bid) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW182Ra01 | CLIA Kit for BH3 Interacting Domain Death Agonist (Bid) | CLIA assay for Antigen Detection |
| ELW182Ra01 | ELISA Kit for BH3 Interacting Domain Death Agonist (Bid) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW182Ca01 | Recombinant BH3 Interacting Domain Death Agonist (Bid) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW182Ca01 | Monoclonal Antibody to BH3 Interacting Domain Death Agonist (Bid) | WB; IHC; ICC; IP. |
| PAW182Ca01 | Polyclonal Antibody to BH3 Interacting Domain Death Agonist (Bid) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW182Ca01 | CLIA Kit for BH3 Interacting Domain Death Agonist (Bid) | CLIA assay for Antigen Detection |
| ELW182Ca01 | ELISA Kit for BH3 Interacting Domain Death Agonist (Bid) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW182Po01 | Recombinant BH3 Interacting Domain Death Agonist (Bid) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW182Po01 | Monoclonal Antibody to BH3 Interacting Domain Death Agonist (Bid) | WB; IHC; ICC; IP. |
| PAW182Po01 | Polyclonal Antibody to BH3 Interacting Domain Death Agonist (Bid) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW182Po01 | CLIA Kit for BH3 Interacting Domain Death Agonist (Bid) | CLIA assay for Antigen Detection |
| ELW182Po01 | ELISA Kit for BH3 Interacting Domain Death Agonist (Bid) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW182Bo01 | Recombinant BH3 Interacting Domain Death Agonist (Bid) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW182Bo01 | Monoclonal Antibody to BH3 Interacting Domain Death Agonist (Bid) | WB; IHC; ICC; IP. |
| PAW182Bo01 | Polyclonal Antibody to BH3 Interacting Domain Death Agonist (Bid) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW182Bo01 | CLIA Kit for BH3 Interacting Domain Death Agonist (Bid) | CLIA assay for Antigen Detection |
| ELW182Bo01 | ELISA Kit for BH3 Interacting Domain Death Agonist (Bid) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW182Rb01 | Recombinant BH3 Interacting Domain Death Agonist (Bid) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW182Rb01 | Monoclonal Antibody to BH3 Interacting Domain Death Agonist (Bid) | WB; IHC; ICC; IP. |
| PAW182Rb01 | Polyclonal Antibody to BH3 Interacting Domain Death Agonist (Bid) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW182Rb01 | CLIA Kit for BH3 Interacting Domain Death Agonist (Bid) | CLIA assay for Antigen Detection |
| ELW182Rb01 | ELISA Kit for BH3 Interacting Domain Death Agonist (Bid) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW182Mo01 | Recombinant BH3 Interacting Domain Death Agonist (Bid) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW182Mo01 | Monoclonal Antibody to BH3 Interacting Domain Death Agonist (Bid) | WB; IHC; ICC; IP. |
| PAW182Mo01 | Polyclonal Antibody to BH3 Interacting Domain Death Agonist (Bid) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW182Mo01 | CLIA Kit for BH3 Interacting Domain Death Agonist (Bid) | CLIA assay for Antigen Detection |
| ELW182Mo01 | ELISA Kit for BH3 Interacting Domain Death Agonist (Bid) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"BID: a novel BH3 domain-only death agonist."
Genes Dev. 10:2859-2869(1996) [PubMed] [Europe PMC] [Abstract]
"The gene for death agonist BID maps to the region of human 22q11.2 duplicated in cat eye syndrome chromosomes and to mouse chromosome 6."
Genomics 51:472-475(1998) [PubMed] [Europe PMC] [Abstract]
"Three novel Bid proteins generated by alternative splicing of the human Bid gene."
J. Biol. Chem. 279:2846-2855(2004) [PubMed] [Europe PMC] [Abstract]
"A genome annotation-driven approach to cloning the human ORFeome."
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
"The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid."
FEBS J. 277:1319-1330(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Solution structure of BID, an intracellular amplifier of apoptotic signaling."
Cell 96:615-624(1999) [PubMed] [Europe PMC] [Abstract]