Glutathione S Transferase Mu 4 (GSTm4)
GST-M4; GSTM4-4; GTM4
The mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. In the August 2009 issue of Oncogene journal, researchers at Huntsman Cancer Institute (HCI) at the University of Utah demonstrated that expression levels of GSTM4 could predict response to chemotherapy in patients with Ewing's Sarcoma. The study found that patients who did not respond to chemotherapy had high levels of GSTM4.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW168Hu01 | Recombinant Glutathione S Transferase Mu 4 (GSTm4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW168Hu01 | Monoclonal Antibody to Glutathione S Transferase Mu 4 (GSTm4) | WB; IHC; ICC; IP. |
| PAW168Hu01 | Polyclonal Antibody to Glutathione S Transferase Mu 4 (GSTm4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW168Hu01 | CLIA Kit for Glutathione S Transferase Mu 4 (GSTm4) | CLIA assay for Antigen Detection |
| ELW168Hu01 | ELISA Kit for Glutathione S Transferase Mu 4 (GSTm4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW168Mu01 | Recombinant Glutathione S Transferase Mu 4 (GSTm4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW168Mu01 | Monoclonal Antibody to Glutathione S Transferase Mu 4 (GSTm4) | WB; IHC; ICC; IP. |
| PAW168Mu01 | Polyclonal Antibody to Glutathione S Transferase Mu 4 (GSTm4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW168Mu01 | CLIA Kit for Glutathione S Transferase Mu 4 (GSTm4) | CLIA assay for Antigen Detection |
| ELW168Mu01 | ELISA Kit for Glutathione S Transferase Mu 4 (GSTm4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW168Ra01 | Recombinant Glutathione S Transferase Mu 4 (GSTm4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW168Ra01 | Monoclonal Antibody to Glutathione S Transferase Mu 4 (GSTm4) | WB; IHC; ICC; IP. |
| PAW168Ra01 | Polyclonal Antibody to Glutathione S Transferase Mu 4 (GSTm4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW168Ra01 | CLIA Kit for Glutathione S Transferase Mu 4 (GSTm4) | CLIA assay for Antigen Detection |
| ELW168Ra01 | ELISA Kit for Glutathione S Transferase Mu 4 (GSTm4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW168Ca01 | Recombinant Glutathione S Transferase Mu 4 (GSTm4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW168Ca01 | Monoclonal Antibody to Glutathione S Transferase Mu 4 (GSTm4) | WB; IHC; ICC; IP. |
| PAW168Ca01 | Polyclonal Antibody to Glutathione S Transferase Mu 4 (GSTm4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW168Ca01 | CLIA Kit for Glutathione S Transferase Mu 4 (GSTm4) | CLIA assay for Antigen Detection |
| ELW168Ca01 | ELISA Kit for Glutathione S Transferase Mu 4 (GSTm4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW168Po01 | Recombinant Glutathione S Transferase Mu 4 (GSTm4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW168Po01 | Monoclonal Antibody to Glutathione S Transferase Mu 4 (GSTm4) | WB; IHC; ICC; IP. |
| PAW168Po01 | Polyclonal Antibody to Glutathione S Transferase Mu 4 (GSTm4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW168Po01 | CLIA Kit for Glutathione S Transferase Mu 4 (GSTm4) | CLIA assay for Antigen Detection |
| ELW168Po01 | ELISA Kit for Glutathione S Transferase Mu 4 (GSTm4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW168Bo01 | Recombinant Glutathione S Transferase Mu 4 (GSTm4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW168Bo01 | Monoclonal Antibody to Glutathione S Transferase Mu 4 (GSTm4) | WB; IHC; ICC; IP. |
| PAW168Bo01 | Polyclonal Antibody to Glutathione S Transferase Mu 4 (GSTm4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW168Bo01 | CLIA Kit for Glutathione S Transferase Mu 4 (GSTm4) | CLIA assay for Antigen Detection |
| ELW168Bo01 | ELISA Kit for Glutathione S Transferase Mu 4 (GSTm4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW168Rb01 | Recombinant Glutathione S Transferase Mu 4 (GSTm4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW168Rb01 | Monoclonal Antibody to Glutathione S Transferase Mu 4 (GSTm4) | WB; IHC; ICC; IP. |
| PAW168Rb01 | Polyclonal Antibody to Glutathione S Transferase Mu 4 (GSTm4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW168Rb01 | CLIA Kit for Glutathione S Transferase Mu 4 (GSTm4) | CLIA assay for Antigen Detection |
| ELW168Rb01 | ELISA Kit for Glutathione S Transferase Mu 4 (GSTm4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW168Mo01 | Recombinant Glutathione S Transferase Mu 4 (GSTm4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW168Mo01 | Monoclonal Antibody to Glutathione S Transferase Mu 4 (GSTm4) | WB; IHC; ICC; IP. |
| PAW168Mo01 | Polyclonal Antibody to Glutathione S Transferase Mu 4 (GSTm4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW168Mo01 | CLIA Kit for Glutathione S Transferase Mu 4 (GSTm4) | CLIA assay for Antigen Detection |
| ELW168Mo01 | ELISA Kit for Glutathione S Transferase Mu 4 (GSTm4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Isolation and analysis of the gene and cDNA for a human Mu class glutathione S-transferase, GSTM4."
J. Biol. Chem. 268:16958-16965(1993) [PubMed] [Europe PMC] [Abstract]
"Deduced amino acid sequence, gene structure and chromosomal location of a novel human class Mu glutathione S-transferase, GSTM4."
Biochem. J. 291:41-50(1993) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript."
Biochem. J. 294:373-380(1993) [PubMed] [Europe PMC] [Abstract]
"Screening for inter-individual splicing differences in human GSTM4 and the discovery of a single nucleotide substitution related to the tandem skipping of two exons."
Gene 379:148-155(2006) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Structure of human glutathione S-transferase class Mu genes."
Biochem. J. 274:587-593(1991) [PubMed] [Europe PMC] [Abstract]
"A comparison of the enzymatic and physicochemical properties of human glutathione transferase M4-4 and three other human Mu class enzymes."
Arch. Biochem. Biophys. 311:487-495(1994) [PubMed] [Europe PMC] [Abstract]
"An asparagine-phenylalanine substitution accounts for catalytic differences between hGSTM3-3 and other human class mu glutathione S-transferases."
Biochemistry 38:16187-16194(1999) [PubMed] [Europe PMC] [Abstract]