Mothers Against Decapentaplegic Homolog 1 (Smad1)
BSP1; JV4-1; JV41; MADH1; MADR1; SMAD Family Member 1; Mad-related protein 1; Transforming growth factor-beta-signaling protein 1; Mothers against DPP homolog 1
belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The name is a combination of the two. It was found that a mutation in the 'Drosophila' gene, MAD, in the mother, repressed the gene, decapentaplegic, in the embryo. The phrase "Mothers against" was added as a humorous approach since mothers often form organizations opposing various issues eg. This protein mediates the signals of the bone morphogenetic proteins, which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW164Hu01 | Recombinant Mothers Against Decapentaplegic Homolog 1 (Smad1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW164Hu01 | Monoclonal Antibody to Mothers Against Decapentaplegic Homolog 1 (Smad1) | WB; IHC; ICC; IP. |
| PAW164Hu01 | Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 1 (Smad1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW164Hu01 | CLIA Kit for Mothers Against Decapentaplegic Homolog 1 (Smad1) | CLIA assay for Antigen Detection |
| ELW164Hu01 | ELISA Kit for Mothers Against Decapentaplegic Homolog 1 (Smad1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW164Mu01 | Recombinant Mothers Against Decapentaplegic Homolog 1 (Smad1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW164Mu01 | Monoclonal Antibody to Mothers Against Decapentaplegic Homolog 1 (Smad1) | WB; IHC; ICC; IP. |
| PAW164Mu01 | Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 1 (Smad1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW164Mu01 | CLIA Kit for Mothers Against Decapentaplegic Homolog 1 (Smad1) | CLIA assay for Antigen Detection |
| ELW164Mu01 | ELISA Kit for Mothers Against Decapentaplegic Homolog 1 (Smad1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW164Ra01 | Recombinant Mothers Against Decapentaplegic Homolog 1 (Smad1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW164Ra01 | Monoclonal Antibody to Mothers Against Decapentaplegic Homolog 1 (Smad1) | WB; IHC; ICC; IP. |
| PAW164Ra01 | Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 1 (Smad1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW164Ra01 | CLIA Kit for Mothers Against Decapentaplegic Homolog 1 (Smad1) | CLIA assay for Antigen Detection |
| ELW164Ra01 | ELISA Kit for Mothers Against Decapentaplegic Homolog 1 (Smad1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW164Ca01 | Recombinant Mothers Against Decapentaplegic Homolog 1 (Smad1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW164Ca01 | Monoclonal Antibody to Mothers Against Decapentaplegic Homolog 1 (Smad1) | WB; IHC; ICC; IP. |
| PAW164Ca01 | Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 1 (Smad1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW164Ca01 | CLIA Kit for Mothers Against Decapentaplegic Homolog 1 (Smad1) | CLIA assay for Antigen Detection |
| ELW164Ca01 | ELISA Kit for Mothers Against Decapentaplegic Homolog 1 (Smad1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW164Po01 | Recombinant Mothers Against Decapentaplegic Homolog 1 (Smad1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW164Po01 | Monoclonal Antibody to Mothers Against Decapentaplegic Homolog 1 (Smad1) | WB; IHC; ICC; IP. |
| PAW164Po01 | Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 1 (Smad1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW164Po01 | CLIA Kit for Mothers Against Decapentaplegic Homolog 1 (Smad1) | CLIA assay for Antigen Detection |
| ELW164Po01 | ELISA Kit for Mothers Against Decapentaplegic Homolog 1 (Smad1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW164Bo01 | Recombinant Mothers Against Decapentaplegic Homolog 1 (Smad1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW164Bo01 | Monoclonal Antibody to Mothers Against Decapentaplegic Homolog 1 (Smad1) | WB; IHC; ICC; IP. |
| PAW164Bo01 | Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 1 (Smad1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW164Bo01 | CLIA Kit for Mothers Against Decapentaplegic Homolog 1 (Smad1) | CLIA assay for Antigen Detection |
| ELW164Bo01 | ELISA Kit for Mothers Against Decapentaplegic Homolog 1 (Smad1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW164Rb01 | Recombinant Mothers Against Decapentaplegic Homolog 1 (Smad1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW164Rb01 | Monoclonal Antibody to Mothers Against Decapentaplegic Homolog 1 (Smad1) | WB; IHC; ICC; IP. |
| PAW164Rb01 | Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 1 (Smad1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW164Rb01 | CLIA Kit for Mothers Against Decapentaplegic Homolog 1 (Smad1) | CLIA assay for Antigen Detection |
| ELW164Rb01 | ELISA Kit for Mothers Against Decapentaplegic Homolog 1 (Smad1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW164Mo01 | Recombinant Mothers Against Decapentaplegic Homolog 1 (Smad1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW164Mo01 | Monoclonal Antibody to Mothers Against Decapentaplegic Homolog 1 (Smad1) | WB; IHC; ICC; IP. |
| PAW164Mo01 | Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 1 (Smad1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW164Mo01 | CLIA Kit for Mothers Against Decapentaplegic Homolog 1 (Smad1) | CLIA assay for Antigen Detection |
| ELW164Mo01 | ELISA Kit for Mothers Against Decapentaplegic Homolog 1 (Smad1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Mad-related genes in the human."
Nat. Genet. 13:347-349(1996) [PubMed] [Europe PMC] [Abstract]
"A human Mad protein acting as a BMP-regulated transcriptional activator."
Nature 381:620-623(1996) [PubMed] [Europe PMC] [Abstract]
"MADR1, a MAD-related protein that functions in BMP2 signaling pathways."
Cell 85:489-500(1996) [PubMed] [Europe PMC] [Abstract]
"Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1."
J. Biol. Chem. 271:17617-17620(1996) [PubMed] [Europe PMC] [Abstract]
"Receptor-associated Mad homologues synergize as effectors of the TGF-beta response."
Nature 383:168-172(1996) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]