Calcium/Calmodulin Dependent Protein Kinase II Gamma (CAMK2g)

CAMKII; CAMK2G; CAMK; CAMK-II; CAMKG; CaM Kinase; CaM kinase II subunit gamma; CaMK-II subunit gamma

SPN	W156
HGNC	1463
MGI	88259
PubMed	12032636
RGD	621802
UniProt	Q13555
Wiki	CAMK2G

Calcium/calmodulin-dependent protein kinase type II gamma chain is an enzyme belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. T

he product of this gene is a gamma chain. Six alternatively spliced variants that encode six different isoforms have been characterized to date. Additional alternative splice variants that encode different isoforms have been described, but their full-length nature has not been determined.

Reference

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human islets of Langerhans express multiple isoforms of calcium/calmodulin-dependent protein kinase II."
Biochem. Biophys. Res. Commun. 236:473-478(1997) [PubMed] [Europe PMC] [Abstract]

"Human calcium/calmodulin-dependent protein kinase II gamma: cloning, genomic structure and detection of variants in subjects with type II diabetes."
Diabetologia 45:580-583(2002) [PubMed] [Europe PMC] [Abstract]

"Cloning and analysis of two new isoforms of multifunctional Ca2+/calmodulin-dependent protein kinase. Expression in multiple human tissues."
J. Biol. Chem. 268:5471-5479(1993) [PubMed] [Europe PMC] [Abstract]

"Identification of novel human tumor cell-specific CaMK-II variants."
Biochim. Biophys. Acta 1355:281-292(1997) [PubMed] [Europe PMC] [Abstract]

"Human biliary epithelial cell line Mz-ChA-1 expresses new isoforms of calmodulin-dependent protein kinase II."
Gastroenterology 109:1316-1323(1995) [PubMed] [Europe PMC] [Abstract]

"Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II."
J. Biol. Chem. 279:12484-12494(2004) [PubMed] [Europe PMC] [Abstract]

"Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise."
J. Physiol. (Lond.) 574:889-903(2006) [PubMed] [Europe PMC] [Abstract]

"The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis."
Proc. Nutrit. Soc. 63:279-286(2004) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation."
PLoS Biol. 8:E1000426-E1000426(2010) [PubMed] [Europe PMC] [Abstract]

"Diagnostic exome sequencing in persons with severe intellectual disability."
N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]