Slit Homolog 2 (Slit2)
SLIL3
Slit2 plays a vital role in axon guidance by signaling through Robo receptors. Recent evidence suggests that Slit2 protein may function in other settings because human and Xenopus Slit2 has been shown to inhibit leukocyte chemotaxis. SLIT2 protein is a putative ligand for the ROBO receptors. ROBO1 is inactivated by promoter region hypermethylation in <20% of human cancers. Slit2 is an excellent candidate tumor suppressor gene for colorectal cancer，and that it epigenetically silenced in >40% of lung and breast tumors. SLIT2 promoter region methylation was found in 23 (72%) of 32 primary colorectal cancers. In contrast, normal colorectal mucosa from the same patients exhibited significantly lower levels of SLIT2 promoter region hypermethylation.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW140Hu01 | Recombinant Slit Homolog 2 (Slit2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW140Hu01 | Monoclonal Antibody to Slit Homolog 2 (Slit2) | WB; IHC; ICC; IP. |
| PAW140Hu01 | Polyclonal Antibody to Slit Homolog 2 (Slit2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW140Hu01 | CLIA Kit for Slit Homolog 2 (Slit2) | CLIA assay for Antigen Detection |
| ELW140Hu01 | ELISA Kit for Slit Homolog 2 (Slit2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW140Mu01 | Recombinant Slit Homolog 2 (Slit2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW140Mu01 | Monoclonal Antibody to Slit Homolog 2 (Slit2) | WB; IHC; ICC; IP. |
| PAW140Mu01 | Polyclonal Antibody to Slit Homolog 2 (Slit2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW140Mu01 | CLIA Kit for Slit Homolog 2 (Slit2) | CLIA assay for Antigen Detection |
| ELW140Mu01 | ELISA Kit for Slit Homolog 2 (Slit2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW140Ra01 | Recombinant Slit Homolog 2 (Slit2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW140Ra01 | Monoclonal Antibody to Slit Homolog 2 (Slit2) | WB; IHC; ICC; IP. |
| PAW140Ra01 | Polyclonal Antibody to Slit Homolog 2 (Slit2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW140Ra01 | CLIA Kit for Slit Homolog 2 (Slit2) | CLIA assay for Antigen Detection |
| ELW140Ra01 | ELISA Kit for Slit Homolog 2 (Slit2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW140Ca01 | Recombinant Slit Homolog 2 (Slit2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW140Ca01 | Monoclonal Antibody to Slit Homolog 2 (Slit2) | WB; IHC; ICC; IP. |
| PAW140Ca01 | Polyclonal Antibody to Slit Homolog 2 (Slit2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW140Ca01 | CLIA Kit for Slit Homolog 2 (Slit2) | CLIA assay for Antigen Detection |
| ELW140Ca01 | ELISA Kit for Slit Homolog 2 (Slit2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW140Po01 | Recombinant Slit Homolog 2 (Slit2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW140Po01 | Monoclonal Antibody to Slit Homolog 2 (Slit2) | WB; IHC; ICC; IP. |
| PAW140Po01 | Polyclonal Antibody to Slit Homolog 2 (Slit2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW140Po01 | CLIA Kit for Slit Homolog 2 (Slit2) | CLIA assay for Antigen Detection |
| ELW140Po01 | ELISA Kit for Slit Homolog 2 (Slit2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW140Bo01 | Recombinant Slit Homolog 2 (Slit2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW140Bo01 | Monoclonal Antibody to Slit Homolog 2 (Slit2) | WB; IHC; ICC; IP. |
| PAW140Bo01 | Polyclonal Antibody to Slit Homolog 2 (Slit2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW140Bo01 | CLIA Kit for Slit Homolog 2 (Slit2) | CLIA assay for Antigen Detection |
| ELW140Bo01 | ELISA Kit for Slit Homolog 2 (Slit2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW140Rb01 | Recombinant Slit Homolog 2 (Slit2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW140Rb01 | Monoclonal Antibody to Slit Homolog 2 (Slit2) | WB; IHC; ICC; IP. |
| PAW140Rb01 | Polyclonal Antibody to Slit Homolog 2 (Slit2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW140Rb01 | CLIA Kit for Slit Homolog 2 (Slit2) | CLIA assay for Antigen Detection |
| ELW140Rb01 | ELISA Kit for Slit Homolog 2 (Slit2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW140Mo01 | Recombinant Slit Homolog 2 (Slit2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW140Mo01 | Monoclonal Antibody to Slit Homolog 2 (Slit2) | WB; IHC; ICC; IP. |
| PAW140Mo01 | Polyclonal Antibody to Slit Homolog 2 (Slit2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW140Mo01 | CLIA Kit for Slit Homolog 2 (Slit2) | CLIA assay for Antigen Detection |
| ELW140Mo01 | ELISA Kit for Slit Homolog 2 (Slit2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system."
Brain Res. Mol. Brain Res. 62:175-186(1998) [PubMed] [Europe PMC] [Abstract]
"Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis."
Mech. Dev. 79:57-72(1998) [PubMed] [Europe PMC] [Abstract]
"Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance."
Cell 96:795-806(1999) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord."
Cell 102:363-375(2000) [PubMed] [Europe PMC] [Abstract]
"Slit2 is a repellent for retinal ganglion cell axons."
J. Neurosci. 20:4962-4974(2000) [PubMed] [Europe PMC] [Abstract]
"The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors."
Nature 410:948-952(2001) [PubMed] [Europe PMC] [Abstract]
"The N-terminal leucine-rich regions in Slit are sufficient to repel olfactory bulb axons and subventricular zone neurons."
J. Neurosci. 21:1548-1556(2001) [PubMed] [Europe PMC] [Abstract]
"Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance."
J. Neurosci. 21:4281-4289(2001) [PubMed] [Europe PMC] [Abstract]
"Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex."
Science 291:1928-1938(2001) [PubMed] [Europe PMC] [Abstract]
"Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes."
Curr. Opin. Genet. Dev. 12:583-591(2002) [PubMed] [Europe PMC] [Abstract]
"Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3."
Acta Crystallogr. D 63:961-968(2007) [PubMed] [Europe PMC] [Abstract]
"Structural insights into the Slit-Robo complex."
Proc. Natl. Acad. Sci. U.S.A. 104:14923-14928(2007) [PubMed] [Europe PMC] [Abstract]
"Structure and functional relevance of the Slit2 homodimerization domain."
EMBO Rep. 10:736-741(2009) [PubMed] [Europe PMC] [Abstract]