Toll Like Receptor 6 (TLR6)
CD286
Toll Like Receptor 6 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. By screening a human placenta library with a mouse Tlr6 probe, Takeuchi et al. (1999) isolated a cDNA encoding human TLR6. The deduced 796-amino acid type I transmembrane protein, which is 74% identical to mouse Tlr6 and 69% identical to TLR1, contains an N-terminal signal peptide, 20 tandemly repeated extracellular leucine-rich motifs, and a cytoplasmic domain homologous to IL1R, as seen in other TLRs. RT-PCR analysis detected Tlr6 in mouse thymus, spleen, ovary, and lung.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW129Hu01 | Recombinant Toll Like Receptor 6 (TLR6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW129Hu01 | Monoclonal Antibody to Toll Like Receptor 6 (TLR6) | WB; IHC; ICC; IP. |
| PAW129Hu01 | Polyclonal Antibody to Toll Like Receptor 6 (TLR6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW129Hu01 | CLIA Kit for Toll Like Receptor 6 (TLR6) | CLIA assay for Antigen Detection |
| ELW129Hu01 | ELISA Kit for Toll Like Receptor 6 (TLR6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW129Mu01 | Recombinant Toll Like Receptor 6 (TLR6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW129Mu01 | Monoclonal Antibody to Toll Like Receptor 6 (TLR6) | WB; IHC; ICC; IP. |
| PAW129Mu01 | Polyclonal Antibody to Toll Like Receptor 6 (TLR6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW129Mu01 | CLIA Kit for Toll Like Receptor 6 (TLR6) | CLIA assay for Antigen Detection |
| ELW129Mu01 | ELISA Kit for Toll Like Receptor 6 (TLR6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW129Ra01 | Recombinant Toll Like Receptor 6 (TLR6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW129Ra01 | Monoclonal Antibody to Toll Like Receptor 6 (TLR6) | WB; IHC; ICC; IP. |
| PAW129Ra01 | Polyclonal Antibody to Toll Like Receptor 6 (TLR6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW129Ra01 | CLIA Kit for Toll Like Receptor 6 (TLR6) | CLIA assay for Antigen Detection |
| ELW129Ra01 | ELISA Kit for Toll Like Receptor 6 (TLR6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW129Ca01 | Recombinant Toll Like Receptor 6 (TLR6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW129Ca01 | Monoclonal Antibody to Toll Like Receptor 6 (TLR6) | WB; IHC; ICC; IP. |
| PAW129Ca01 | Polyclonal Antibody to Toll Like Receptor 6 (TLR6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW129Ca01 | CLIA Kit for Toll Like Receptor 6 (TLR6) | CLIA assay for Antigen Detection |
| ELW129Ca01 | ELISA Kit for Toll Like Receptor 6 (TLR6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW129Po01 | Recombinant Toll Like Receptor 6 (TLR6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW129Po01 | Monoclonal Antibody to Toll Like Receptor 6 (TLR6) | WB; IHC; ICC; IP. |
| PAW129Po01 | Polyclonal Antibody to Toll Like Receptor 6 (TLR6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW129Po01 | CLIA Kit for Toll Like Receptor 6 (TLR6) | CLIA assay for Antigen Detection |
| ELW129Po01 | ELISA Kit for Toll Like Receptor 6 (TLR6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW129Bo01 | Recombinant Toll Like Receptor 6 (TLR6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW129Bo01 | Monoclonal Antibody to Toll Like Receptor 6 (TLR6) | WB; IHC; ICC; IP. |
| PAW129Bo01 | Polyclonal Antibody to Toll Like Receptor 6 (TLR6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW129Bo01 | CLIA Kit for Toll Like Receptor 6 (TLR6) | CLIA assay for Antigen Detection |
| ELW129Bo01 | ELISA Kit for Toll Like Receptor 6 (TLR6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW129Rb01 | Recombinant Toll Like Receptor 6 (TLR6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW129Rb01 | Monoclonal Antibody to Toll Like Receptor 6 (TLR6) | WB; IHC; ICC; IP. |
| PAW129Rb01 | Polyclonal Antibody to Toll Like Receptor 6 (TLR6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW129Rb01 | CLIA Kit for Toll Like Receptor 6 (TLR6) | CLIA assay for Antigen Detection |
| ELW129Rb01 | ELISA Kit for Toll Like Receptor 6 (TLR6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW129Mo01 | Recombinant Toll Like Receptor 6 (TLR6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW129Mo01 | Monoclonal Antibody to Toll Like Receptor 6 (TLR6) | WB; IHC; ICC; IP. |
| PAW129Mo01 | Polyclonal Antibody to Toll Like Receptor 6 (TLR6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW129Mo01 | CLIA Kit for Toll Like Receptor 6 (TLR6) | CLIA assay for Antigen Detection |
| ELW129Mo01 | ELISA Kit for Toll Like Receptor 6 (TLR6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"TLR6: a novel member of an expanding Toll-like receptor family."
Gene 231:59-65(1999) [PubMed] [Europe PMC] [Abstract]
"Natural selection in the TLR-related genes in the course of primate evolution."
Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling."
J. Immunol. 167:987-994(2001) [PubMed] [Europe PMC] [Abstract]
"CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer."
Nat. Immunol. 11:155-161(2010) [PubMed] [Europe PMC] [Abstract]
"Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family."
Hum. Mutat. 32:643-652(2011) [PubMed] [Europe PMC] [Abstract]