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Cluster Of Differentiation 14 (CD14)

Monocyte differentiation antigen CD14; Myeloid cell-specific leucine-rich glycoprotein

CD14 exists in two forms. It is either anchored into the membrane by a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14). Soluble CD14 appears either after shedding of mCD14 (48 KDa) or is directly secreted from intracellular vesicles (56 KDa).CD14 takes its name from its inclusion in the cluster of differentiation group of cell surface marker proteins. CD14 was the first described pattern recognition receptor.CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide (LPS). CD14 can only bind LPS in the presence of lipopolysaccharide-binding protein (LBP). Although LPS is considered its main ligand CD14 also recognizes other pathogen associated molecular patterns.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW127Hu01 Recombinant Cluster Of Differentiation 14 (CD14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW127Hu01 Monoclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
PAW127Hu01 Polyclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IF.
Assay Kits CLW127Hu01 CLIA Kit for Cluster Of Differentiation 14 (CD14) CLIA assay for Antigen Detection
ELW127Hu01 ELISA Kit for Cluster Of Differentiation 14 (CD14) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW127Mu01 Recombinant Cluster Of Differentiation 14 (CD14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW127Mu01 Monoclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
PAW127Mu01 Polyclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IF.
Assay Kits CLW127Mu01 CLIA Kit for Cluster Of Differentiation 14 (CD14) CLIA assay for Antigen Detection
ELW127Mu01 ELISA Kit for Cluster Of Differentiation 14 (CD14) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW127Ra01 Recombinant Cluster Of Differentiation 14 (CD14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW127Ra01 Monoclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
PAW127Ra01 Polyclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IF.
Assay Kits CLW127Ra01 CLIA Kit for Cluster Of Differentiation 14 (CD14) CLIA assay for Antigen Detection
ELW127Ra01 ELISA Kit for Cluster Of Differentiation 14 (CD14) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW127Ca01 Recombinant Cluster Of Differentiation 14 (CD14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW127Ca01 Monoclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
PAW127Ca01 Polyclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IF.
Assay Kits CLW127Ca01 CLIA Kit for Cluster Of Differentiation 14 (CD14) CLIA assay for Antigen Detection
ELW127Ca01 ELISA Kit for Cluster Of Differentiation 14 (CD14) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW127Po01 Recombinant Cluster Of Differentiation 14 (CD14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW127Po01 Monoclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
PAW127Po01 Polyclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IF.
Assay Kits CLW127Po01 CLIA Kit for Cluster Of Differentiation 14 (CD14) CLIA assay for Antigen Detection
ELW127Po01 ELISA Kit for Cluster Of Differentiation 14 (CD14) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW127Bo01 Recombinant Cluster Of Differentiation 14 (CD14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW127Bo01 Monoclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
PAW127Bo01 Polyclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IF.
Assay Kits CLW127Bo01 CLIA Kit for Cluster Of Differentiation 14 (CD14) CLIA assay for Antigen Detection
ELW127Bo01 ELISA Kit for Cluster Of Differentiation 14 (CD14) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW127Rb01 Recombinant Cluster Of Differentiation 14 (CD14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW127Rb01 Monoclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
PAW127Rb01 Polyclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IF.
Assay Kits CLW127Rb01 CLIA Kit for Cluster Of Differentiation 14 (CD14) CLIA assay for Antigen Detection
ELW127Rb01 ELISA Kit for Cluster Of Differentiation 14 (CD14) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW127Mo01 Recombinant Cluster Of Differentiation 14 (CD14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW127Mo01 Monoclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
PAW127Mo01 Polyclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IF.
Assay Kits CLW127Mo01 CLIA Kit for Cluster Of Differentiation 14 (CD14) CLIA assay for Antigen Detection
ELW127Mo01 ELISA Kit for Cluster Of Differentiation 14 (CD14) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage."
J. Immunol. 141:547-552(1988) [PubMed] [Europe PMC] [Abstract]

"Nucleotide sequence of the gene encoding the monocyte differentiation antigen, CD14."
Nucleic Acids Res. 16:4173-4173(1988) [PubMed] [Europe PMC] [Abstract]

"Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones."
Biochim. Biophys. Acta 1008:213-222(1989) [PubMed] [Europe PMC] [Abstract]

"Monocyte antigen CD14 is a phospholipid anchored membrane protein."
Blood 73:284-289(1989) [PubMed] [Europe PMC] [Abstract]

"Cloning and sequencing of human CD14 gene."
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Jin Zhan 25:377-378(1998)

"Natural selection in the TLR-related genes in the course of primate evolution."
Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structural relationship between the soluble and membrane-bound forms of human monocyte surface glycoprotein CD14."
Mol. Immunol. 26:657-662(1989) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Enrichment of glycopeptides for glycan structure and attachment site identification."
Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"The crystal structure of human soluble CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket."
J. Immunol. 190:1304-1311(2013) [PubMed] [Europe PMC] [Abstract]