Kallikrein 8 (KLK8)
NP; HNP; NRPN; PRSS19; TADG14; BSP1; Neuropsin; Ovasin; Brain Serine Protease 1; Tumor Associated Differentially Expressed Gene 14; Serine protease 19
Originally described from mouse brain, KLK8 was implicated in neural plasticity and learning. Kallikrein 8 is thought to be involved in neurite outgrowth and fasciculation during nervous system development. Kallikrein 8 is induced in neurite injury, and Kallikrein 8 has been shown to be elevated in the hippocampus on Alzheimer’s patients.
Kallikrein 8 is thought to regulate the early phase of long-term potentiation (LTP), possibly by cleaving fibronectin and other substrates.Kallikrein 8 is also found in the uterus, where it is hormonally regulated. Cervical cancer cell lines express high levels of Kallikrein 8, and it may be useful as a tumor marker. Kallikrein 8 is not limited to the brain and uterus, as many tissues and cell lines make the protein.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW122Hu01 | Recombinant Kallikrein 8 (KLK8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW122Hu01 | Monoclonal Antibody to Kallikrein 8 (KLK8) | WB; IHC; ICC; IP. |
| PAW122Hu01 | Polyclonal Antibody to Kallikrein 8 (KLK8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW122Hu01 | CLIA Kit for Kallikrein 8 (KLK8) | CLIA assay for Antigen Detection |
| ELW122Hu01 | ELISA Kit for Kallikrein 8 (KLK8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW122Mu01 | Recombinant Kallikrein 8 (KLK8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW122Mu01 | Monoclonal Antibody to Kallikrein 8 (KLK8) | WB; IHC; ICC; IP. |
| PAW122Mu01 | Polyclonal Antibody to Kallikrein 8 (KLK8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW122Mu01 | CLIA Kit for Kallikrein 8 (KLK8) | CLIA assay for Antigen Detection |
| ELW122Mu01 | ELISA Kit for Kallikrein 8 (KLK8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW122Ra01 | Recombinant Kallikrein 8 (KLK8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW122Ra01 | Monoclonal Antibody to Kallikrein 8 (KLK8) | WB; IHC; ICC; IP. |
| PAW122Ra01 | Polyclonal Antibody to Kallikrein 8 (KLK8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW122Ra01 | CLIA Kit for Kallikrein 8 (KLK8) | CLIA assay for Antigen Detection |
| ELW122Ra01 | ELISA Kit for Kallikrein 8 (KLK8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW122Ca01 | Recombinant Kallikrein 8 (KLK8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW122Ca01 | Monoclonal Antibody to Kallikrein 8 (KLK8) | WB; IHC; ICC; IP. |
| PAW122Ca01 | Polyclonal Antibody to Kallikrein 8 (KLK8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW122Ca01 | CLIA Kit for Kallikrein 8 (KLK8) | CLIA assay for Antigen Detection |
| ELW122Ca01 | ELISA Kit for Kallikrein 8 (KLK8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW122Po01 | Recombinant Kallikrein 8 (KLK8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW122Po01 | Monoclonal Antibody to Kallikrein 8 (KLK8) | WB; IHC; ICC; IP. |
| PAW122Po01 | Polyclonal Antibody to Kallikrein 8 (KLK8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW122Po01 | CLIA Kit for Kallikrein 8 (KLK8) | CLIA assay for Antigen Detection |
| ELW122Po01 | ELISA Kit for Kallikrein 8 (KLK8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW122Bo01 | Recombinant Kallikrein 8 (KLK8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW122Bo01 | Monoclonal Antibody to Kallikrein 8 (KLK8) | WB; IHC; ICC; IP. |
| PAW122Bo01 | Polyclonal Antibody to Kallikrein 8 (KLK8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW122Bo01 | CLIA Kit for Kallikrein 8 (KLK8) | CLIA assay for Antigen Detection |
| ELW122Bo01 | ELISA Kit for Kallikrein 8 (KLK8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW122Rb01 | Recombinant Kallikrein 8 (KLK8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW122Rb01 | Monoclonal Antibody to Kallikrein 8 (KLK8) | WB; IHC; ICC; IP. |
| PAW122Rb01 | Polyclonal Antibody to Kallikrein 8 (KLK8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW122Rb01 | CLIA Kit for Kallikrein 8 (KLK8) | CLIA assay for Antigen Detection |
| ELW122Rb01 | ELISA Kit for Kallikrein 8 (KLK8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW122Mo01 | Recombinant Kallikrein 8 (KLK8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW122Mo01 | Monoclonal Antibody to Kallikrein 8 (KLK8) | WB; IHC; ICC; IP. |
| PAW122Mo01 | Polyclonal Antibody to Kallikrein 8 (KLK8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW122Mo01 | CLIA Kit for Kallikrein 8 (KLK8) | CLIA assay for Antigen Detection |
| ELW122Mo01 | ELISA Kit for Kallikrein 8 (KLK8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Sequence analysis and expression of human neuropsin cDNA and gene."
Gene 213:9-16(1998) [PubMed] [Europe PMC] [Abstract]
"Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma."
Cancer Res. 59:4435-4439(1999) [PubMed] [Europe PMC] [Abstract]
"A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain."
Eur. J. Biochem. 260:627-634(1999) [PubMed] [Europe PMC] [Abstract]
"Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
"The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer."
Clin. Cancer Res. 7:806-811(2001) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Recent origin of a hominoid-specific splice form of neuropsin, a gene involved in learning and memory."
Mol. Biol. Evol. 21:2111-2115(2004) [PubMed] [Europe PMC] [Abstract]
"Expression of the kallikrein gene family in normal and Alzheimer's disease brain."
NeuroReport 12:2747-2751(2001) [PubMed] [Europe PMC] [Abstract]
"Epidermal expression of serine protease, neuropsin (KLK8) in normal and pathological skin samples."
Mol. Pathol. 55:235-241(2002) [PubMed] [Europe PMC] [Abstract]
"Human kallikrein 8, a novel biomarker for ovarian carcinoma."
Cancer Res. 63:2771-2774(2003) [PubMed] [Europe PMC] [Abstract]
"Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins."
FEBS Lett. 579:6879-6884(2005) [PubMed] [Europe PMC] [Abstract]
"A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory."
Hum. Mutat. 28:978-984(2007) [PubMed] [Europe PMC] [Abstract]
"SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes."
J. Biochem. 142:435-442(2007) [PubMed] [Europe PMC] [Abstract]
"SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor."
J. Invest. Dermatol. 129:1656-1665(2009) [PubMed] [Europe PMC] [Abstract]