Kallikrein 6 (KLK6)
ZYME; Bssp; Klk7; Neurosin,Zyme; PRSS18; PRSS9; SP59; HK6; Protease M; Serine protease 18
Kallikrein 6, also known as Zyme, Neurosin, PRSS9, myelencephalon-specific protease (MSP) and protease M, is a trypsin-like serine proteinase. Kallikrein 6 was originally described from the brain as an enzyme involved in degradation of amyloid plaque protein (APP) and hK6 was thought to be a beta secretase.
Kallikrein 6 was shown to be elevated in the sera patients with Alzheimer’s disease and Parkinson’s disease and in animal models of multiple sclerosis. The neuronal protein alpha-synuclein was shown to be cleaved by hK6, as has APP and hK6 has been implicated in vascular morphogenesis and angiogenesis. MSP has also been shown to rapidly degrade myelin-specific protein, laminin and fibronectin.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW121Hu01 | Recombinant Kallikrein 6 (KLK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW121Hu01 | Monoclonal Antibody to Kallikrein 6 (KLK6) | WB; IHC; ICC; IP. |
| PAW121Hu01 | Polyclonal Antibody to Kallikrein 6 (KLK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW121Hu01 | CLIA Kit for Kallikrein 6 (KLK6) | CLIA assay for Antigen Detection |
| ELW121Hu01 | ELISA Kit for Kallikrein 6 (KLK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW121Mu01 | Recombinant Kallikrein 6 (KLK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW121Mu01 | Monoclonal Antibody to Kallikrein 6 (KLK6) | WB; IHC; ICC; IP. |
| PAW121Mu01 | Polyclonal Antibody to Kallikrein 6 (KLK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW121Mu01 | CLIA Kit for Kallikrein 6 (KLK6) | CLIA assay for Antigen Detection |
| ELW121Mu01 | ELISA Kit for Kallikrein 6 (KLK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW121Ra01 | Recombinant Kallikrein 6 (KLK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW121Ra01 | Monoclonal Antibody to Kallikrein 6 (KLK6) | WB; IHC; ICC; IP. |
| PAW121Ra01 | Polyclonal Antibody to Kallikrein 6 (KLK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW121Ra01 | CLIA Kit for Kallikrein 6 (KLK6) | CLIA assay for Antigen Detection |
| ELW121Ra01 | ELISA Kit for Kallikrein 6 (KLK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW121Ca01 | Recombinant Kallikrein 6 (KLK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW121Ca01 | Monoclonal Antibody to Kallikrein 6 (KLK6) | WB; IHC; ICC; IP. |
| PAW121Ca01 | Polyclonal Antibody to Kallikrein 6 (KLK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW121Ca01 | CLIA Kit for Kallikrein 6 (KLK6) | CLIA assay for Antigen Detection |
| ELW121Ca01 | ELISA Kit for Kallikrein 6 (KLK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW121Po01 | Recombinant Kallikrein 6 (KLK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW121Po01 | Monoclonal Antibody to Kallikrein 6 (KLK6) | WB; IHC; ICC; IP. |
| PAW121Po01 | Polyclonal Antibody to Kallikrein 6 (KLK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW121Po01 | CLIA Kit for Kallikrein 6 (KLK6) | CLIA assay for Antigen Detection |
| ELW121Po01 | ELISA Kit for Kallikrein 6 (KLK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW121Bo01 | Recombinant Kallikrein 6 (KLK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW121Bo01 | Monoclonal Antibody to Kallikrein 6 (KLK6) | WB; IHC; ICC; IP. |
| PAW121Bo01 | Polyclonal Antibody to Kallikrein 6 (KLK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW121Bo01 | CLIA Kit for Kallikrein 6 (KLK6) | CLIA assay for Antigen Detection |
| ELW121Bo01 | ELISA Kit for Kallikrein 6 (KLK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW121Rb01 | Recombinant Kallikrein 6 (KLK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW121Rb01 | Monoclonal Antibody to Kallikrein 6 (KLK6) | WB; IHC; ICC; IP. |
| PAW121Rb01 | Polyclonal Antibody to Kallikrein 6 (KLK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW121Rb01 | CLIA Kit for Kallikrein 6 (KLK6) | CLIA assay for Antigen Detection |
| ELW121Rb01 | ELISA Kit for Kallikrein 6 (KLK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW121Mo01 | Recombinant Kallikrein 6 (KLK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW121Mo01 | Monoclonal Antibody to Kallikrein 6 (KLK6) | WB; IHC; ICC; IP. |
| PAW121Mo01 | Polyclonal Antibody to Kallikrein 6 (KLK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW121Mo01 | CLIA Kit for Kallikrein 6 (KLK6) | CLIA assay for Antigen Detection |
| ELW121Mo01 | ELISA Kit for Kallikrein 6 (KLK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A novel protease homolog differentially expressed in breast and ovarian cancer."
Mol. Med. 2:624-636(1996) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain."
Biochim. Biophys. Acta 1350:11-14(1997) [PubMed] [Europe PMC] [Abstract]
"Zyme, a novel and potentially amyloidogenic enzyme cDNA isolated from Alzheimer's disease brain."
J. Biol. Chem. 272:25135-25142(1997) [PubMed] [Europe PMC] [Abstract]
"Molecular characterization of Zyme/protease M/neurosin(PRSS9), a hormonally regulated kallikrein-like serine protease."
Genomics 62:251-259(1999) [PubMed] [Europe PMC] [Abstract]
"Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
"Cloning and characterization of novel isoforms of the human kallikrein 6 gene."
Biochem. Biophys. Res. Commun. 320:54-61(2004) [PubMed] [Europe PMC] [Abstract]
"Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer."
Biol. Chem. 387:773-782(2006) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Immunofluorometric assay of human kallikrein 6 (zyme/protease M/neurosin) and preliminary clinical applications."
Clin. Biochem. 33:369-375(2000) [PubMed] [Europe PMC] [Abstract]
"Localization of a novel type trypsin-like serine protease, neurosin, in brain tissues of Alzheimer's disease and Parkinson's disease."
Psychiatry Clin. Neurosci. 54:419-426(2000) [PubMed] [Europe PMC] [Abstract]
"The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry."
J. Histochem. Cytochem. 49:1431-1441(2001) [PubMed] [Europe PMC] [Abstract]
"Characterization of the enzymatic activity of human kallikrein 6: autoactivation, substrate specificity, and regulation by inhibitors."
Biochem. Biophys. Res. Commun. 307:948-955(2003) [PubMed] [Europe PMC] [Abstract]
"Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies."
Hum. Mol. Genet. 12:2625-2635(2003) [PubMed] [Europe PMC] [Abstract]
"Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells."
Tumor Biol. 25:193-199(2004) [PubMed] [Europe PMC] [Abstract]
"Dynamic role of kallikrein 6 in traumatic spinal cord injury."
Eur. J. Neurosci. 24:1457-1469(2006) [PubMed] [Europe PMC] [Abstract]
"Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects."
J. Biol. Chem. 281:3116-3126(2006) [PubMed] [Europe PMC] [Abstract]
"The autolytic regulation of human kallikrein-related peptidase 6."
Biochemistry 46:5209-5217(2007) [PubMed] [Europe PMC] [Abstract]
"The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family."
J. Biol. Chem. 277:27273-27281(2002) [PubMed] [Europe PMC] [Abstract]
"Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system."
J. Biol. Chem. 277:24562-24570(2002) [PubMed] [Europe PMC] [Abstract]