Neuropilin 1 (NRP1)
CD304; BDCA4; VEGF165R; Vascular endothelial cell growth factor 165 receptor
Neuropilin is a protein receptor active in neurons.There are two forms of Neuropilins, NRP-1 and NRP-2. They are transmembrane glycoproteins, and predominantly co-receptors for another class of proteins known as Semaphorins. Of the Semaphorins, NRP-1 and NRP-2 are specifically receptors for Class-3 Semaphorins, which, amongst many things, are responsible for axon guidance during the development of the nervous system in vertebrates. Neuropilins work as co-receptors as they have a very small cytoplasmic domain and thus rely upon other molecules to transduce their signals across a cell membrane, normally Plexins. Neuropilins generally work as dimers and different combinations have different affinities for molecules. .
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW120Hu01 | Recombinant Neuropilin 1 (NRP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW120Hu01 | Monoclonal Antibody to Neuropilin 1 (NRP1) | WB; IHC; ICC; IP. |
| PAW120Hu01 | Polyclonal Antibody to Neuropilin 1 (NRP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW120Hu01 | CLIA Kit for Neuropilin 1 (NRP1) | CLIA assay for Antigen Detection |
| ELW120Hu01 | ELISA Kit for Neuropilin 1 (NRP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW120Mu01 | Recombinant Neuropilin 1 (NRP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW120Mu01 | Monoclonal Antibody to Neuropilin 1 (NRP1) | WB; IHC; ICC; IP. |
| PAW120Mu01 | Polyclonal Antibody to Neuropilin 1 (NRP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW120Mu01 | CLIA Kit for Neuropilin 1 (NRP1) | CLIA assay for Antigen Detection |
| ELW120Mu01 | ELISA Kit for Neuropilin 1 (NRP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW120Ra01 | Recombinant Neuropilin 1 (NRP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW120Ra01 | Monoclonal Antibody to Neuropilin 1 (NRP1) | WB; IHC; ICC; IP. |
| PAW120Ra01 | Polyclonal Antibody to Neuropilin 1 (NRP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW120Ra01 | CLIA Kit for Neuropilin 1 (NRP1) | CLIA assay for Antigen Detection |
| ELW120Ra01 | ELISA Kit for Neuropilin 1 (NRP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW120Ca01 | Recombinant Neuropilin 1 (NRP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW120Ca01 | Monoclonal Antibody to Neuropilin 1 (NRP1) | WB; IHC; ICC; IP. |
| PAW120Ca01 | Polyclonal Antibody to Neuropilin 1 (NRP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW120Ca01 | CLIA Kit for Neuropilin 1 (NRP1) | CLIA assay for Antigen Detection |
| ELW120Ca01 | ELISA Kit for Neuropilin 1 (NRP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW120Po01 | Recombinant Neuropilin 1 (NRP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW120Po01 | Monoclonal Antibody to Neuropilin 1 (NRP1) | WB; IHC; ICC; IP. |
| PAW120Po01 | Polyclonal Antibody to Neuropilin 1 (NRP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW120Po01 | CLIA Kit for Neuropilin 1 (NRP1) | CLIA assay for Antigen Detection |
| ELW120Po01 | ELISA Kit for Neuropilin 1 (NRP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW120Bo01 | Recombinant Neuropilin 1 (NRP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW120Bo01 | Monoclonal Antibody to Neuropilin 1 (NRP1) | WB; IHC; ICC; IP. |
| PAW120Bo01 | Polyclonal Antibody to Neuropilin 1 (NRP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW120Bo01 | CLIA Kit for Neuropilin 1 (NRP1) | CLIA assay for Antigen Detection |
| ELW120Bo01 | ELISA Kit for Neuropilin 1 (NRP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW120Rb01 | Recombinant Neuropilin 1 (NRP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW120Rb01 | Monoclonal Antibody to Neuropilin 1 (NRP1) | WB; IHC; ICC; IP. |
| PAW120Rb01 | Polyclonal Antibody to Neuropilin 1 (NRP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW120Rb01 | CLIA Kit for Neuropilin 1 (NRP1) | CLIA assay for Antigen Detection |
| ELW120Rb01 | ELISA Kit for Neuropilin 1 (NRP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW120Mo01 | Recombinant Neuropilin 1 (NRP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW120Mo01 | Monoclonal Antibody to Neuropilin 1 (NRP1) | WB; IHC; ICC; IP. |
| PAW120Mo01 | Polyclonal Antibody to Neuropilin 1 (NRP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW120Mo01 | CLIA Kit for Neuropilin 1 (NRP1) | CLIA assay for Antigen Detection |
| ELW120Mo01 | ELISA Kit for Neuropilin 1 (NRP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Neuropilin is a receptor for the axonal chemorepellent semaphorin III."
Cell 90:739-751(1997) [PubMed] [Europe PMC] [Abstract]
"Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor."
Cell 92:735-745(1998) [PubMed] [Europe PMC] [Abstract]
"Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: in vivo expression and antitumor activity."
Proc. Natl. Acad. Sci. U.S.A. 97:2573-2578(2000) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates."
Cell 99:71-80(1999) [PubMed] [Europe PMC] [Abstract]
"Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165."
J. Biol. Chem. 275:18040-18045(2000) [PubMed] [Europe PMC] [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
"Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling."
EMBO J. 25:3045-3055(2006) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the human neuropilin-1 b1 domain."
Structure 11:99-108(2003) [PubMed] [Europe PMC] [Abstract]
"Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding."
EMBO J. 26:4902-4912(2007) [PubMed] [Europe PMC] [Abstract]