Call Now

Thioredoxin Reductase 1 (TrxR1)

TXNRD1; TR1; GRIM12; KDRF; TRXR-1; TXNR; Gene associated with retinoic and interferon-induced mortality 12 protein; KM-102-derived reductase-like factor

Thioredoxin reductase 1, cytoplasmic is a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW109Hu01 Recombinant Thioredoxin Reductase 1 (TrxR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW109Hu01 Monoclonal Antibody to Thioredoxin Reductase 1 (TrxR1) WB; IHC; ICC; IP.
PAW109Hu01 Polyclonal Antibody to Thioredoxin Reductase 1 (TrxR1) WB; IHC; ICC; IF.
Assay Kits CLW109Hu01 CLIA Kit for Thioredoxin Reductase 1 (TrxR1) CLIA assay for Antigen Detection
ELW109Hu01 ELISA Kit for Thioredoxin Reductase 1 (TrxR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW109Mu01 Recombinant Thioredoxin Reductase 1 (TrxR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW109Mu01 Monoclonal Antibody to Thioredoxin Reductase 1 (TrxR1) WB; IHC; ICC; IP.
PAW109Mu01 Polyclonal Antibody to Thioredoxin Reductase 1 (TrxR1) WB; IHC; ICC; IF.
Assay Kits CLW109Mu01 CLIA Kit for Thioredoxin Reductase 1 (TrxR1) CLIA assay for Antigen Detection
ELW109Mu01 ELISA Kit for Thioredoxin Reductase 1 (TrxR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW109Ra01 Recombinant Thioredoxin Reductase 1 (TrxR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW109Ra01 Monoclonal Antibody to Thioredoxin Reductase 1 (TrxR1) WB; IHC; ICC; IP.
PAW109Ra01 Polyclonal Antibody to Thioredoxin Reductase 1 (TrxR1) WB; IHC; ICC; IF.
Assay Kits CLW109Ra01 CLIA Kit for Thioredoxin Reductase 1 (TrxR1) CLIA assay for Antigen Detection
ELW109Ra01 ELISA Kit for Thioredoxin Reductase 1 (TrxR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW109Ca01 Recombinant Thioredoxin Reductase 1 (TrxR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW109Ca01 Monoclonal Antibody to Thioredoxin Reductase 1 (TrxR1) WB; IHC; ICC; IP.
PAW109Ca01 Polyclonal Antibody to Thioredoxin Reductase 1 (TrxR1) WB; IHC; ICC; IF.
Assay Kits CLW109Ca01 CLIA Kit for Thioredoxin Reductase 1 (TrxR1) CLIA assay for Antigen Detection
ELW109Ca01 ELISA Kit for Thioredoxin Reductase 1 (TrxR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW109Po01 Recombinant Thioredoxin Reductase 1 (TrxR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW109Po01 Monoclonal Antibody to Thioredoxin Reductase 1 (TrxR1) WB; IHC; ICC; IP.
PAW109Po01 Polyclonal Antibody to Thioredoxin Reductase 1 (TrxR1) WB; IHC; ICC; IF.
Assay Kits CLW109Po01 CLIA Kit for Thioredoxin Reductase 1 (TrxR1) CLIA assay for Antigen Detection
ELW109Po01 ELISA Kit for Thioredoxin Reductase 1 (TrxR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW109Bo01 Recombinant Thioredoxin Reductase 1 (TrxR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW109Bo01 Monoclonal Antibody to Thioredoxin Reductase 1 (TrxR1) WB; IHC; ICC; IP.
PAW109Bo01 Polyclonal Antibody to Thioredoxin Reductase 1 (TrxR1) WB; IHC; ICC; IF.
Assay Kits CLW109Bo01 CLIA Kit for Thioredoxin Reductase 1 (TrxR1) CLIA assay for Antigen Detection
ELW109Bo01 ELISA Kit for Thioredoxin Reductase 1 (TrxR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW109Rb01 Recombinant Thioredoxin Reductase 1 (TrxR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW109Rb01 Monoclonal Antibody to Thioredoxin Reductase 1 (TrxR1) WB; IHC; ICC; IP.
PAW109Rb01 Polyclonal Antibody to Thioredoxin Reductase 1 (TrxR1) WB; IHC; ICC; IF.
Assay Kits CLW109Rb01 CLIA Kit for Thioredoxin Reductase 1 (TrxR1) CLIA assay for Antigen Detection
ELW109Rb01 ELISA Kit for Thioredoxin Reductase 1 (TrxR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW109Mo01 Recombinant Thioredoxin Reductase 1 (TrxR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW109Mo01 Monoclonal Antibody to Thioredoxin Reductase 1 (TrxR1) WB; IHC; ICC; IP.
PAW109Mo01 Polyclonal Antibody to Thioredoxin Reductase 1 (TrxR1) WB; IHC; ICC; IF.
Assay Kits CLW109Mo01 CLIA Kit for Thioredoxin Reductase 1 (TrxR1) CLIA assay for Antigen Detection
ELW109Mo01 ELISA Kit for Thioredoxin Reductase 1 (TrxR1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Cloning and sequencing of a human thioredoxin reductase."
FEBS Lett. 373:5-9(1995) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of a novel oxidoreductase KDRF from a human bone marrow-derived stromal cell line KM-102."
J. Biol. Chem. 272:2570-2577(1997) [PubMed] [Europe PMC] [Abstract]

"Thioredoxin reductase mediates cell death effects of the combination of beta interferon and retinoic acid."
Mol. Cell. Biol. 18:6493-6504(1998) [PubMed] [Europe PMC] [Abstract]

"Evidence for intriguingly complex transcription of human thioredoxin reductase 1."
Free Radic. Biol. Med. 36:641-656(2004) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene."
Proc. Natl. Acad. Sci. U.S.A. 93:6146-6151(1996) [PubMed] [Europe PMC] [Abstract]

"A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity."
Proc. Natl. Acad. Sci. U.S.A. 93:1006-1011(1996) [PubMed] [Europe PMC] [Abstract]

"Alternative splicing involving the thioredoxin reductase module in mammals: a glutaredoxin-containing thioredoxin reductase 1."
Biochemistry 43:12177-12188(2004) [PubMed] [Europe PMC] [Abstract]

"An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling."
J. Biol. Chem. 279:38721-38729(2004) [PubMed] [Europe PMC] [Abstract]

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

"HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets."
Proc. Natl. Acad. Sci. U.S.A. 103:10735-10740(2006) [PubMed] [Europe PMC] [Abstract]

"Induction of cell membrane protrusions by the N-terminal glutaredoxin domain of a rare splice variant of human thioredoxin reductase 1."
J. Biol. Chem. 283:2814-2821(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

"The structure of human thioredoxin reductase 1 provides insights into C-terminal rearrangements during catalysis."
J. Mol. Biol. 370:116-127(2007) [PubMed] [Europe PMC] [Abstract]