Prostaglandin D2 Synthase, Brain (PGD2S)

PTGDS; PDS; PGDS2; Prostaglandin-H2 D-Isomerase; Lipocalin-Type Prostaglandin D Synthase; Cerebrin-28; Beta-trace protein; Glutathione-independent PGD synthase

SPN	W088
HGNC	9592
MGI	99261
PubMed	11703586
RGD	3433
UniProt	P41222
Wiki	PGD2S

PTGDS isa glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice over-expressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. Furthermore, PTGDS and its product PGD2 are elevated in the bald-scalp areas of men with male pattern baldness. Prostaglandin D2 synthase is used clinically as a diagnostic marker for liquorrhea, that is, to check whether fluid leaking from the nose or ear contains cerebrospinal fluid.

Reference

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Submitted (JAN-2010) to the PDB data bank