Call Now

Prostaglandin Endoperoxide Synthase 1 (PTGS1)

COX1; COX3; PCOX1; PGG/HS; PGHS1; PHS1; PTGHS; Cyclooxygenase 1; Prostaglandin H2 Synthase 1; Prostaglandin G/H Synthase And Cyclooxygenase

There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Recent research has shown that the inhibition of COX-1 is the main reason why aspirin is effective at reducing cardiac events (as opposed to aspirin's anti-platelet aggregation effects).

PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants called COX-1 and COX-3. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW084Hu01 Recombinant Prostaglandin Endoperoxide Synthase 1 (PTGS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW084Hu01 Monoclonal Antibody to Prostaglandin Endoperoxide Synthase 1 (PTGS1) WB; IHC; ICC; IP.
PAW084Hu01 Polyclonal Antibody to Prostaglandin Endoperoxide Synthase 1 (PTGS1) WB; IHC; ICC; IF.
Assay Kits CLW084Hu01 CLIA Kit for Prostaglandin Endoperoxide Synthase 1 (PTGS1) CLIA assay for Antigen Detection
ELW084Hu01 ELISA Kit for Prostaglandin Endoperoxide Synthase 1 (PTGS1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW084Mu01 Recombinant Prostaglandin Endoperoxide Synthase 1 (PTGS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW084Mu01 Monoclonal Antibody to Prostaglandin Endoperoxide Synthase 1 (PTGS1) WB; IHC; ICC; IP.
PAW084Mu01 Polyclonal Antibody to Prostaglandin Endoperoxide Synthase 1 (PTGS1) WB; IHC; ICC; IF.
Assay Kits CLW084Mu01 CLIA Kit for Prostaglandin Endoperoxide Synthase 1 (PTGS1) CLIA assay for Antigen Detection
ELW084Mu01 ELISA Kit for Prostaglandin Endoperoxide Synthase 1 (PTGS1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW084Ra01 Recombinant Prostaglandin Endoperoxide Synthase 1 (PTGS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW084Ra01 Monoclonal Antibody to Prostaglandin Endoperoxide Synthase 1 (PTGS1) WB; IHC; ICC; IP.
PAW084Ra01 Polyclonal Antibody to Prostaglandin Endoperoxide Synthase 1 (PTGS1) WB; IHC; ICC; IF.
Assay Kits CLW084Ra01 CLIA Kit for Prostaglandin Endoperoxide Synthase 1 (PTGS1) CLIA assay for Antigen Detection
ELW084Ra01 ELISA Kit for Prostaglandin Endoperoxide Synthase 1 (PTGS1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW084Ca01 Recombinant Prostaglandin Endoperoxide Synthase 1 (PTGS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW084Ca01 Monoclonal Antibody to Prostaglandin Endoperoxide Synthase 1 (PTGS1) WB; IHC; ICC; IP.
PAW084Ca01 Polyclonal Antibody to Prostaglandin Endoperoxide Synthase 1 (PTGS1) WB; IHC; ICC; IF.
Assay Kits CLW084Ca01 CLIA Kit for Prostaglandin Endoperoxide Synthase 1 (PTGS1) CLIA assay for Antigen Detection
ELW084Ca01 ELISA Kit for Prostaglandin Endoperoxide Synthase 1 (PTGS1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW084Po01 Recombinant Prostaglandin Endoperoxide Synthase 1 (PTGS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW084Po01 Monoclonal Antibody to Prostaglandin Endoperoxide Synthase 1 (PTGS1) WB; IHC; ICC; IP.
PAW084Po01 Polyclonal Antibody to Prostaglandin Endoperoxide Synthase 1 (PTGS1) WB; IHC; ICC; IF.
Assay Kits CLW084Po01 CLIA Kit for Prostaglandin Endoperoxide Synthase 1 (PTGS1) CLIA assay for Antigen Detection
ELW084Po01 ELISA Kit for Prostaglandin Endoperoxide Synthase 1 (PTGS1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW084Bo01 Recombinant Prostaglandin Endoperoxide Synthase 1 (PTGS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW084Bo01 Monoclonal Antibody to Prostaglandin Endoperoxide Synthase 1 (PTGS1) WB; IHC; ICC; IP.
PAW084Bo01 Polyclonal Antibody to Prostaglandin Endoperoxide Synthase 1 (PTGS1) WB; IHC; ICC; IF.
Assay Kits CLW084Bo01 CLIA Kit for Prostaglandin Endoperoxide Synthase 1 (PTGS1) CLIA assay for Antigen Detection
ELW084Bo01 ELISA Kit for Prostaglandin Endoperoxide Synthase 1 (PTGS1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW084Rb01 Recombinant Prostaglandin Endoperoxide Synthase 1 (PTGS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW084Rb01 Monoclonal Antibody to Prostaglandin Endoperoxide Synthase 1 (PTGS1) WB; IHC; ICC; IP.
PAW084Rb01 Polyclonal Antibody to Prostaglandin Endoperoxide Synthase 1 (PTGS1) WB; IHC; ICC; IF.
Assay Kits CLW084Rb01 CLIA Kit for Prostaglandin Endoperoxide Synthase 1 (PTGS1) CLIA assay for Antigen Detection
ELW084Rb01 ELISA Kit for Prostaglandin Endoperoxide Synthase 1 (PTGS1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW084Mo01 Recombinant Prostaglandin Endoperoxide Synthase 1 (PTGS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW084Mo01 Monoclonal Antibody to Prostaglandin Endoperoxide Synthase 1 (PTGS1) WB; IHC; ICC; IP.
PAW084Mo01 Polyclonal Antibody to Prostaglandin Endoperoxide Synthase 1 (PTGS1) WB; IHC; ICC; IF.
Assay Kits CLW084Mo01 CLIA Kit for Prostaglandin Endoperoxide Synthase 1 (PTGS1) CLIA assay for Antigen Detection
ELW084Mo01 ELISA Kit for Prostaglandin Endoperoxide Synthase 1 (PTGS1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme."
Biochem. Biophys. Res. Commun. 165:888-894(1989) [PubMed] [Europe PMC] [Abstract]

"Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment."
FASEB J. 5:2304-2312(1991) [PubMed] [Europe PMC] [Abstract]

"Immunoaffinity purification and cDNA cloning of human platelet prostaglandin endoperoxide synthase (cyclooxygenase)."
Biochem. Biophys. Res. Commun. 182:433-438(1992) [PubMed] [Europe PMC] [Abstract]

"Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by transforming growth factor beta 1, interleukin 1 beta, and tumor necrosis factor alpha."
J. Biol. Chem. 267:10816-10822(1992) [PubMed] [Europe PMC] [Abstract]

"Cloning, expression, and functional characterization of human cyclooxygenase-1 splicing variants: evidence for intron 1 retention."
J. Pharmacol. Exp. Ther. 315:1298-1305(2005) [PubMed] [Europe PMC] [Abstract]

"Characterization of the human prostaglandin H synthase 1 gene (PTGS1): exclusion by genetic linkage analysis as a second modifier gene in familial thrombosis."
Blood Coagul. Fibrinolysis 13:519-531(2002) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cyclooxygenases: structural, cellular, and molecular biology."
Annu. Rev. Biochem. 69:145-182(2000) [PubMed] [Europe PMC] [Abstract]

"Aspirin, cyclooxygenase inhibition and colorectal cancer."
World J. Gastrointest. Pharmacol. Ther. 5:40-49(2014) [PubMed] [Europe PMC] [Abstract]

"Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk."
Carcinogenesis 25:2467-2472(2004) [PubMed] [Europe PMC] [Abstract]